Review
Biotechnology & Applied Microbiology
Arundhathi Dev, Meenakshi Vachher, Chandra Prakash Prasad
Summary: beta-catenin is a crucial protein involved in various cellular processes, including cellular homeostasis, embryonic development, and cancer. It functions as a signaling molecule and also plays a role in cell adhesion. Aberrant expression of beta-catenin promotes the transcription of oncogenes and contributes to tumorigenesis. Understanding the regulation of beta-catenin is important for understanding the mechanisms of cancer progression.
Article
Integrative & Complementary Medicine
Li Yue-jun, Liao Lin-li, Liu Pei, Tang Ping, Wang Hong, Peng Qing-hua
Summary: SJZD inhibits the development and proliferation of gastric cancer stem cells by attenuating the transcriptional activity of beta-catenin.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Oncology
Hui Hua, Tao Su, Linyu Han, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang
Summary: This study identified a novel oncogenic lncRNA, LINC01226, transcribed from the 1p35.2 GC-risk locus, which is highly expressed in GC and associated with worse prognosis. LINC01226 promotes proliferation, migration, and metastasis of GC cells and activates the Wnt/beta-catenin signaling pathway.
Article
Cell Biology
Heidi Espadas-Alvarez, Jacqueline Martinez-Rendon, Isabel Larre, Arturo Matamoros-Volante, Tatiana Romero-Garcia, Tamara Rosenbaum, Angelica Rueda, Refugio Garcia-Villegas
Summary: TRPV4 channel functions in the nucleus, inhibiting the transcriptional activity of beta-catenin through a direct interaction, and may regulate differentiation in various cellular contexts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Jia Liu, Xiufeng Chen, Xianrong Zhou, Ruokun Yi, Zhennai Yang, Xin Zhao
Summary: The study showed that L. fermentum ZS09 could inhibit the EMT and angiogenesis pathways by suppressing the Wnt/beta-catenin signalling pathway, thus inhibiting tumor metastasis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Yuxiang Chen, Mo Chen, Kai Deng
Summary: Colorectal cancer (CRC) is a common malignant tumor in the digestive system, with increasing incidence and high mortality rate. Abnormal activation of the Wnt/beta-catenin signaling pathway, which is associated with carcinogenesis, is observed in CRC. Targeting this pathway for the treatment of CRC has clinical value. In recent years, inhibitors have been developed to suppress or hinder the development and progression of CRC by targeting the Wnt/beta-catenin pathway. This review summarizes the role of the Wnt/beta-catenin signaling pathway in CRC, outlines the research status of inhibitors targeting this pathway, and presents potential targets for inhibition of the pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiao Yu, Zhaoshuo Li, Ruihua Bai, Fuxiang Tang
Summary: TCF3 promotes the progression of cervical cancer by activating the SIRT1-mediated beta-catenin signaling pathway, and the high expression of TCF3 in cervical cancer is associated with poor prognosis.
Article
Chemistry, Medicinal
Yi Liu, Leilei Fu, Junhao Wu, Ming Liu, Guan Wang, Bo Liu, Lan Zhang
Summary: CDKs are key regulators of the cell cycle and have multiple functions, including interference with transcriptional events. Inhibiting the function of CDKs may serve as a potential strategy for cancer treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sinjini Bhattacharyya, Ridim D. Mote, Jacob W. Freimer, Mahak Tiwari, Surya Bansi Singh, Sandhya Arumugam, Yadavalli Narayana, Raghav Rajan, Deepa Subramanyam
Summary: E-cadherin plays an important role in cell-cell adhesion in ESCs, but its function in cell fate decisions is not well understood. Study using mESCs found that E-cadherin interacts with beta-catenin at the cell membrane and continues to do so inside the cell. Cdh1(-/-) mESCs were unable to form tight colonies and exhibited altered differentiation, marker expression, and retention of pluripotency factors. Interestingly, Cdh1(-/-) mESCs showed significantly reduced levels of beta-catenin. Transcriptional profiling revealed a significant alteration in the expression of a subset of beta-catenin targets in Cdh1(-/-) mESCs in a cell state- and GSK3 beta-dependent manner.
Article
Multidisciplinary Sciences
Janna Froehlich, Katja Rose, Andreas Hecht
Summary: The unrestrained transcriptional activity of beta-CATENIN and its binding partner TCF7L2 is often found in colorectal tumor initiation and is considered to be an oncogenic driver throughout intestinal carcinogenesis. However, the TCF7L2 gene carries inactivating mutations in some colorectal tumors and is non-essential in colorectal cancer cell lines. This study shows that CRC cells can become independent of TCF7L2 through compensation by other TCF/LEF family members, or they can lose their dependence on beta-CATENIN/TCF7L2-driven gene expression completely. The findings have important implications for evaluating beta-CATENIN and TCF7L2 as potential drug targets.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ghaleb Elyamany, Hassan Rizwan, Ariz Akhter, Mansour S. S. Aljabry, Sultan Alotaibi, Mohammad A. Hameed Albalawi, Meer-Taher Shabani-Rad, Tariq Mahmood Roshan, Adnan Mansoor
Summary: Dysregulated Wnt/beta-catenin signaling is associated with the initiation, propagation, and poor prognosis in AML. Epigenetic inactivation plays a central role in Wnt/beta-catenin hyperactivity, and Wnt/beta-catenin inhibitors are being investigated as potential targeted therapy. Dysregulated Wnt/beta-catenin signaling is also linked to accelerated aging.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Chemistry, Medicinal
Manjinder Singh Phull, Surender Singh Jadav, Rambabu Gundla, Prathama S. Mainkar
Summary: Colorectal cancer is a major cause of carcinogenic mortality, with mutations in the APC gene playing a key role. Current research is focused on developing new anti-colorectal cancer drugs by targeting essential cellular components.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Qi Sun, Boxin Liu, Quanxue Lan, Zijie Su, Qiuxia Fu, Lian Wang, Yingying Deng, Chuanli Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guowu Yang, Desheng Lu
Summary: The study revealed that chloroxylenol could inhibit the Wnt/beta-catenin signaling pathway, leading to anti-tumor effects in colorectal cancer cells, including inhibition of proliferation and migration, induction of apoptosis, and suppression of stemness.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.