Article
Cell Biology
Ze-Bing Song, Yang Yu, Guo-Pei Zhang, Shao-Qiang Li
Summary: A prognostic signature based on genomic instability-derived genes was constructed and validated using data from TCGA and ICGC databases for HCC patients. This signature showed more accurate prediction for prognosis compared to other factors and published signatures. The risk score was identified as an independent prognostic factor for HCC, and a nomogram combining risk score and pathological stage performed well in predicting prognosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Zahra Farzaneh, Massoud Vosough, Tarun Agarwal, Maryam Farzaneh
Summary: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, but current treatment options are not efficient. The liver tumor microenvironment plays a role in HCC progression, and dysregulated signaling pathways contribute to uncontrolled cell growth. Using small molecules to inhibit HCC could be a promising new approach for treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Kwang-Hoon Chun
Summary: This review summarizes the signaling pathways and molecular targets of miR-122 in the progression of hepatocellular carcinoma (HCC), and discusses the importance of miR-122 in therapy.
Review
Genetics & Heredity
Luis M. Ruiz-Manriquez, Oscar Carrasco-Morales, E. Adrian Sanchez, Sofia Madeline Osorio-Perez, Carolina Estrada-Meza, Surajit Pathak, Antara Banerjee, Anindya Bandyopadhyay, Asim K. Duttaroy, Sujay Paul
Summary: This article reviews the microRNA-mediated crucial signaling pathways in hepatocellular carcinoma (HCC), such as PI3K/Akt/mTOR, Hippo-YAP/TAZ, and Wnt/β-catenin, which are of great significance in the management of HCC.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, Research & Experimental
Chuanrui Xu, Zhong Xu, Yi Zhang, Matthias Evert, Diego F. Calvisi, Xin Chen
Summary: Deregulated Wnt/β-catenin signaling is a major genetic alteration in hepatocellular carcinoma (HCC), and its activation plays an oncogenic role in hepatocarcinogenesis. The activated pathway is associated with specific gene expression patterns and pathological features, and it synergizes with other signaling cascades to promote HCC formation. Therefore, understanding and targeting this pathway has important implications for the diagnosis, classification, and personalized treatment of HCC.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Solange Rivas, Arnaldo Marin, Suraj Samtani, Evelin Gonzalez-Feliu, Ricardo Armisen
Summary: The MET gene plays a significant role in lung adenocarcinoma, and its driver mutations contribute to tumor cell migration, invasion, and proliferation. However, the development of drug resistance after MET targeted therapy poses a challenge to precision medicine. Evaluating the patient's MET mutational profile is crucial in devising individualized treatment plans and follow-up processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Summary: The study indicates that antagonizing STK25 signaling inhibits the development of NASH-related HCC, suggesting further analysis of STK25 as a therapeutic target for NASH-induced HCC treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Zhaodan Xin, Jin Li, Haili Zhang, Yi Zhou, Jiajia Song, Piaopiao Chen, Ling Bai, Hao Chen, Juan Zhou, Jie Chen, Binwu Ying
Summary: This study aimed to identify biomarkers for predicting microvascular invasion (MVI) and early recurrence in hepatocellular carcinoma (HCC) by analyzing genomic alterations. The results showed that specific genes had higher mutation rates in MVI patients, and the maximal variant allele frequency (VAF) of circulating tumor DNA (ctDNA) was also higher in MVI patients. Based on these findings, these biomarkers can be utilized to predict MVI and early recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Elsa Bourayou, Rachel Golub
Summary: Immune cells, including the innate lymphoid cells (ILCs), are important in the development and progression of hepatocellular carcinoma (HCC). ILCs are a family of lymphocytes, including Natural Killer (NK) cells, ILC1s, ILC2s, ILC3s and lymphocytes tissue-inducer cells (LTi), that play significant roles in HCC. This overview highlights the importance of diverse signaling pathways in the regulation of ILCs' response to HCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhao Cheng, Hasan Mirza, Darren P. Ennis, Philip Smith, Lena Morrill Gavarro, Chishimba Sokota, Gaia Giannone, Theodora Goranova, Thomas Bradley, Anna Piskorz, Michelle Lockley, Baljeet Kaur, Naveena Singh, Laura A. Tookman, Jonathan Krell, Jacqueline McDermott, Geoffrey Macintyre, Florian Markowetz, James D. Brenton, Iain A. McNeish
Summary: Late-stage and early-stage high-grade serous carcinomas (HGSCs) of the ovary exhibit highly similar patterns of mutation and copy-number alterations. However, late-stage HGSCs show distinct copy-number signature exposures consistent with whole-genome duplication. Further analysis is needed to determine whether these differences reflect genuine biological disparities between early-stage and late-stage disease or simply markers of evolutionary fitness over time.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Hyuk Moon, Simon Weonsang Ro
Summary: The MAPK/ERK signaling pathway is frequently activated in liver cancer, with alternative mechanisms other than genetic mutations driving its activation. Recent studies have focused on understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway in HCC, suggesting potential therapeutic strategies targeting this pathway.
Review
Gastroenterology & Hepatology
Haihong Hu, Taolan Zhang, Yiwen Wu, Meina Deng, Huiling Deng, Xiaoyan Yang
Summary: This paper comprehensively describes the miRNA-related signaling pathways in HCC and the possible interactions among different signaling pathways, aiming to lay the foundation for the discovery of new molecular targets and multi-target therapy.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Mei Zheng, Huan Meng, Yunhui Li, Jingren Shi, Ying Han, Changxu Zhao, Jin Chen, Jinyu Han, Jing Liang, Yuan Chen, Qiqi Liu, Yajie Wang
Summary: S100A11 plays an important role in the development and metastasis of HCC. It can serve as a diagnostic biomarker for HCC and reduce tumor cell proliferation, migration, invasion, and epithelial-mesenchymal transition process by inhibiting the AKT and ERK signaling pathways.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jianqing Yu, Xianfeng Xia, Yujuan Dong, Zhongqin Gong, Gang Li, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 is significantly down-regulated in HCC tumor tissues and its high expression is associated with better prognosis. CYP1A2 functions as a tumor suppressor in HCC by inhibiting HGF/MET signaling and MMPs expression, thus reducing cell growth and invasion capabilities.
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Li-Yu Huang, Xuefei Wang, Xiao-Fang Cui, He Li, Junjie Zhao, Chong-Chao Wu, Lingqiang Min, Zhicheng Zhou, Lixin Wan, Yu-Ping Wang, Chao Zhang, Wei-Qiang Gao, Yihong Sun, Ze-Guang Han
Article
Oncology
Wei Cao, Jian-nan Liu, Zeqi Liu, Xu Wang, Ze-Guang Han, Tong Ji, Wan-tao Chen, Xin Zou
Article
Multidisciplinary Sciences
Yu-Jun Dai, Yue-Ying Wang, Jin-Yan Huang, Li Xia, Xiao-Dong Shi, Jie Xu, Jing Lu, Xian-Bin Su, Ying Yang, Wei-Na Zhang, Pan-Pan Wang, Song-Fang Wu, Ting Huang, Jian-Qing Mi, Ze-Guang Han, Zhu Chen, Sai-Juan Chen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Cardiac & Cardiovascular Systems
Michael Sagner, Amy McNeil, Pekka Puska, Charles Auffray, Nathan D. Price, Leroy Hood, Carl J. Lavie, Ze-Guang Han, Zhu Chen, Samir Kumar Brahmachari, Bruce S. McEwen, Marcelo B. Soares, Rudi Balling, Elissa Epel, Ross Arena
PROGRESS IN CARDIOVASCULAR DISEASES
(2017)
Article
Oncology
Lu-Nan Qi, Bang-De Xiang, Fei-Xiang Wu, Jia-Zhou Ye, Jian-Hong Zhong, Yan-Yan Wang, Yuan-Yuan Chen, Zu-Shun Chen, Liang Ma, Jie Chen, Wen-Feng Gong, Ze-Guang Han, Yan Lu, Jin-Jie Shang, Le-Qun Li
Article
Biotechnology & Applied Microbiology
Yuchen Yuan, Yi Shi, Xianbin Su, Xin Zou, Qing Luo, David Dagan Feng, Weidong Cai, Ze-Guang Han
Article
Multidisciplinary Sciences
Li-Yu Huang, Junjie Zhao, Hao Chen, Lixin Wan, Hiroyuki Inuzuka, Jianping Guo, Xuhong Fu, Yangyang Zhai, Zhaoning Lu, Xuefei Wang, Ze-Guang Han, Yihong Sun, Wenyi Wei
NATURE COMMUNICATIONS
(2018)
Article
Genetics & Heredity
Jiao-Xiang Wu, Kun-Yan He, Zhuang-Zhuang Zhang, Yu-Lan Qu, Xian-Bin Su, Yi Shi, Na Wang, Lan Wang, Ze-Guang Han
Summary: The liver-specific zona pellucida domain-containing protein (LZP) deficiency inhibits VLDL secretion, leading to hepatic TG accumulation and lower serum TG levels, primarily due to decreased levels of apoB protein.
Article
Biochemistry & Molecular Biology
Dan-Dan He, Xue-Ying Shang, Na Wang, Guang-Xing Wang, Kun-Yan He, Lan Wang, Ze-Guang Han
Summary: This study identifies a potential therapeutic strategy for HCC patients with ARID2 mutations by discovering that BRD4 inhibition induces synthetic lethality in ARID2-deficient HCC cells. JQ1, a selective inhibitor, is found to selectively suppress the growth of ARID2-deficient HCC cells by exacerbating DNA damage. Functional assays demonstrate that both BRD4 inhibition and ARID2 deficiency synergistically impede DNA damage repair pathways by attenuating the transcription of core molecules responsible for repair. This study provides insight into a potential therapeutic option for HCC patients with ARID2 mutations.
Article
Cell Biology
Xue-Ying Shang, Yi Shi, Dan-Dan He, Lan Wang, Qing Luo, Chuan-Huai Deng, Yu-Lan Qu, Na Wang, Ze-Guang Han
Summary: This study reveals the impact of ARID1A deficiency on chromatin structure, and shows that ARID1A depletion enhances the invasion capacity of liver cancer cells by regulating the expression of key genes in chromatin organization.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Yangyang Zhai, Kunyan He, Liyu Huang, Xuyang Shang, Guangxing Wang, Guandou Yuan, Ze-Guang Han
Summary: DLK1-directed CAR-T cells specifically eliminate DLK1-positive HCC cells and inhibit tumor growth in vitro and in vivo.
LIVER INTERNATIONAL
(2022)
Article
Toxicology
Lan Wang, Shi-Hao Bai, Shu-Jin Song, Zhao-Ning Lu, Jian Huang, Ze-Guang Han
Summary: A study found that the most common and persistent DNA damage, dA-AL-I adduct, was present in liver cancer patients, suggesting their exposure to aristolochic acids prior to the development of the disease and indicating a worse prognosis. This emphasizes the importance of increasing public awareness to avoid the use of herbal medicine containing aristolochic acids or their derivatives.
TOXICOLOGY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xianbin Su, Yi Shi, Xin Zou, Zhao-Ning Lu, Gangcai Xie, Jean Y. H. Yang, Chong-Chao Wu, Xiao-Fang Cui, Kun-Yan He, Qing Luo, Yu-Lan Qu, Na Wang, Lan Wang, Ze-Guang Han
Article
Biochemistry & Molecular Biology
Sheng Cheng, Lan Wang, Chuan-Huai Deng, Shi-Chun Du, Ze-Guang Han
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Xu Wang, Wei Cao, Jianjun Zhang, Ming Yan, Qin Xu, Xiangbing Wu, Lixin Wan, Zhiyuan Zhang, Chenping Zhang, Xing Qin, Meng Xiao, Dongxia Ye, Yuyang Liu, Zeguang Han, Shaomeng Wang, Li Mao, Wenyi Wei, Wantao Chen