期刊
ACTA PHARMACOLOGICA SINICA
卷 40, 期 1, 页码 9-12出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41401-018-0060-4
关键词
Wnt pathway inhibitors; myocardial infarction; cardiac repairing; therapeutic effect
资金
- National Natural Science Foundation of China [81670277, 31730043]
- Innovation Team of the National Natural Science Foundation [81721001]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1216]
Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing.
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