Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

(2020) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased production of functional small extracellular vesicles in senescent endothelial cells

(2020) Jaime A. Riquelme et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

(2020) Emanuela Mensà et al.   Journal of Extracellular Vesicles

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease

(2020) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

(2020) Erik Ladomersky et al.   CLINICAL CANCER RESEARCH

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

(2019) Cecilia Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

(2019) Yi Sun et al.   Journal of Neuroinflammation

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

(2019) Bérénice A. Benayoun et al.   GENOME RESEARCH

Human Inflammaging

(2019) Tamàs Fülöp et al.   GERONTOLOGY

Polyamines in mammalian pathophysiology

(2019) Francisca Sánchez-Jiménez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of elastin-derived peptides in human physiology and diseases

(2019) Aurélie Le Page et al.   MATRIX BIOLOGY

Neuroprotective offerings by agmatine

(2019) Nandkishor Ramdas Kotagale et al.   NEUROTOXICOLOGY

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation

(2019) Helen Kaiser et al.   Oxidative Medicine and Cellular Longevity

Epigenetic and transcriptional mechanisms for the regulation of IL-10

(2019) Huiyuan Zhang et al.   SEMINARS IN IMMUNOLOGY

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

(2019) Freek J. H. Sorgdrager et al.   Frontiers in Immunology

Activation of immunosuppressive network in the aging process

(2019) Antero Salminen   AGEING RESEARCH REVIEWS

Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway

(2019) Dmitry Kondrikov et al.   EXPERIMENTAL GERONTOLOGY

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

(2018) Lucia Terlecki-Zaniewicz et al.   Aging-US

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

(2018) Antero Salminen et al.   BIOGERONTOLOGY

Interactions among myeloid regulatory cells in cancer

(2018) Viktor Umansky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

(2018) Prashant Rajbhandari et al.   CELL

Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor–Mediated Natural Killer Cell Function

(2018) Andrew Stiff et al.   CLINICAL CANCER RESEARCH

Plasticity and biological diversity of myeloid derived suppressor cells

(2018) Kerem Ben-Meir et al.   CURRENT OPINION IN IMMUNOLOGY

Taking the lead – how keratinocytes orchestrate skin T cell immunity

(2018) M.M. Klicznik et al.   IMMUNOLOGY LETTERS

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

(2018) Charles W. Frevert et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Nitric oxide signalling in cardiovascular health and disease

(2018) Charlotte Farah et al.   Nature Reviews Cardiology

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Impact of Treg on other T cell subsets in progression of fibrosis in experimental lung fibrosis

(2018) Kaustav Chakraborty et al.   TISSUE & CELL

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

(2018) Guoliang Lyu et al.   Nature Communications

TGFβ, smooth muscle cells and coronary artery disease: a review

(2018) Emma L. Low et al.   CELLULAR SIGNALLING

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

(2018) Giada Amodio et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Emerging role for kynurenines in metabolic pathologies

(2018) Jun-Jun Liu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

GM-CSF therapy inhibits chronic graft-versus-host disease via expansion of regulatory T cells

(2018) Masaaki Hotta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

Metabolic pathways of L-arginine and therapeutic consequences in tumors

(2018) Jarosław Szefel et al.   Advances in Medical Sciences

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

(2017) Hyunju Oh et al.   IMMUNITY

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

(2017) Mona El Refaey et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CCR2+ monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-β1

(2017) Astrid Lebrun et al.   JOURNAL OF PATHOLOGY

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

(2017) Peter M. van der Kraan   Nature Reviews Rheumatology

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage phenotype in response to ECM bioscaffolds

(2017) Luai Huleihel et al.   SEMINARS IN IMMUNOLOGY

Reactive oxygen species as signaling molecules in the development of lung fibrosis

(2017) Francisco J. Gonzalez-Gonzalez et al.   Translational Research

Neurodegeneration: Keeping ATF4 on a Tight Leash

(2017) Priyamvada M. Pitale et al.   Frontiers in Cellular Neuroscience

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

(2017) Valentina Rapisarda et al.   Cell Reports

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Nitric oxide mediated inhibition of antigen presentation from DCs to CD4+ T cells in cancer and measurement of STAT1 nitration

(2017) Joseph Markowitz et al.   Scientific Reports

Brain atrophy in Alzheimer’s Disease and aging

(2016) Lorenzo Pini et al.   AGEING RESEARCH REVIEWS

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

The role of IL-11 in immunity and cancer

(2016) Dixon H. Xu et al.   CANCER LETTERS

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

(2016) Johanna Abrigo et al.   CELLULAR SIGNALLING

Interactions between Autophagy and Inhibitory Cytokines

(2016) Tian-tian Wu et al.   International Journal of Biological Sciences

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

(2016) Daniel W. Beury et al.   JOURNAL OF IMMUNOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

(2016) Yun Zhang et al.   Cold Spring Harbor Perspectives in Biology

IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways

(2016) J Shi et al.   Cell Death & Disease

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Myeloid-Derived Suppressor Cells Induce the Expansion of Regulatory B Cells and Ameliorate Autoimmunity in the Sanroque Mouse Model of Systemic Lupus Erythematosus

(2016) Min-Jung Park et al.   Arthritis & Rheumatology

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

Characterization of Liver Monocytic Myeloid-Derived Suppressor Cells and Their Role in a Murine Model of Non-Alcoholic Fatty Liver Disease

(2016) Liying Yao et al.   PLoS One

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide

(2015) Ying Wang et al.   AGING CELL

Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity

(2015) Paola Lucia Minciullo et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

Immunosuppression associated with chronic inflammation in the tumor microenvironment

(2015) Dingzhi Wang et al.   CARCINOGENESIS

Suppression of antigen presentation by IL-10

(2015) Sharad K Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Strategies targeting the IL-4/IL-13 axes in disease

(2015) Richard D. May et al.   CYTOKINE

Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

(2015) Taihao Quan et al.   GERONTOLOGY

Profibrotic Role for Interleukin-4 in Cardiac Remodeling and DysfunctionNovelty and Significance

(2015) Hongmei Peng et al.   HYPERTENSION

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

The expanding family of regulatory B cells

(2015) Claudia Mauri et al.   INTERNATIONAL IMMUNOLOGY

Myeloid-derived suppressor cells contribute to bone erosion in collagen-induced arthritis by differentiating to osteoclasts

(2015) Hui Zhang et al.   JOURNAL OF AUTOIMMUNITY

IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1

(2015) Peter Hsu et al.   JOURNAL OF IMMUNOLOGY

Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy

(2015) Raj Kishore et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Depletion of fat-resident Treg cells prevents age-associated insulin resistance

(2015) Sagar P. Bapat et al.   NATURE

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression

(2015) Jelena Krstić et al.   Oxidative Medicine and Cellular Longevity

The kynurenine pathway and neurodegenerative disease

(2015) Daniel C. Maddison et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis

(2015) Rei Nakamura et al.   Nature Communications

IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway

(2015) Kentaro Sumida et al.   Scientific Reports

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence

(2014) Miroslava Kretova et al.   CELLULAR SIGNALLING

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

(2014) O Palomares et al.   GENES AND IMMUNITY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Human renal fibroblasts generate dendritic cells with a unique regulatory profile

(2014) Karen O Dixon et al.   IMMUNOLOGY AND CELL BIOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

(2014) C. S. Lages et al.   JOURNAL OF IMMUNOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

(2014) Jazmin Reyes Ocampo et al.   Oxidative Medicine and Cellular Longevity

Tif1  regulates the TGF- 1 receptor and promotes physiological aging of hematopoietic stem cells

(2014) R. Quere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation

(2014) Tessa Gaarenstroom et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protein and amino acid restriction, aging and disease: from yeast to humans

(2014) Hamed Mirzaei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease

(2014) Masuo Ohno   Frontiers in Molecular Neuroscience

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

Activation of NAD(P)H Oxidase by Tryptophan-Derived 3-Hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo

(2013) Qiongxin Wang et al.   CIRCULATION RESEARCH

Interleukin-4 Induces Senescence in Human Renal Carcinoma Cell Lines through STAT6 and p38 MAPK

(2013) Hag Dong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer

(2013) Chris P. Verschoor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

(2013) Susan A. Austin et al.   JOURNAL OF NEUROCHEMISTRY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Conditional Expression of TGF-β1 in Skeletal Muscles Causes Endomysial Fibrosis and Myofibers Atrophy

(2013) Jigna Narola et al.   PLoS One

Hypermethylation ofTGF-β1gene promoter in gastric cancer

(2013) Yong-Qi Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Systemic inflammatory response syndrome (SIRS)

(2013) Robert A Balk   Virulence

Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment

(2013) C. S. Hayes et al.   Cancer Immunology Research

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity

(2012) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

(2012) Laura Brudecki et al.   INFECTION AND IMMUNITY

Protective Role of Reactive Oxygen Species in Endotoxin-Induced Lung Inflammation through Modulation of IL-10 Expression

(2012) J. Deng et al.   JOURNAL OF IMMUNOLOGY

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells

(2012) Junling Zhuang et al.   PLoS One

New insights into chronic inflammation-induced immunosuppression

(2012) Julia Kanterman et al.   SEMINARS IN CANCER BIOLOGY

Oxidative Modification of Proteins: An Emerging Mechanism of Cell Signaling

(2012) Stephanie B. Wall et al.   Frontiers in Physiology

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Transforming growth factor-β and atherosclerosis: interwoven atherogenic and atheroprotective aspects

(2011) Ian Toma et al.   CELL AND TISSUE RESEARCH

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300

(2011) Joong-Yeon Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Role for Immature Myeloid Cells in Immune Senescence

(2010) E. Y. Enioutina et al.   JOURNAL OF IMMUNOLOGY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Tau hyperphosphorylation affects Smad 2/3 translocation

(2009) S. Baig et al.   NEUROSCIENCE

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

Induction of p16ink4a and p19ARF by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes

(2008) Kinnimulki Vijayachandra et al.   MOLECULAR CARCINOGENESIS

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

(2008) Morgan E. Carlson et al.   NATURE

Ageing and the regulation of protein synthesis: a balancing act?

(2008) Nektarios Tavernarakis   TRENDS IN CELL BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY