Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

(2013) Amos A. Fatokun et al.   AMINO ACIDS

Nitrite-induced alterations in sex steroids and thyroid hormones of Labeo rohita juveniles: effects of dietary vitamin E and l-tryptophan

(2013) A. Ciji et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Supplementing Healthy Women with up to 5.0 g/d of L-Tryptophan Has No Adverse Effects

(2013) Chiaki Hiratsuka et al.   JOURNAL OF NUTRITION

3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis

(2013) Peter A. LeWitt et al.   MOVEMENT DISORDERS

Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

(2013) Rafael Lugo-Huitrón et al.   Oxidative Medicine and Cellular Longevity

Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease

(2012) Mathuravani A. Thevandavakkam et al.   CNS & Neurological Disorders-Drug Targets

Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer’s disease patients from controls

(2012) Markus J. Schwarz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Drosophila eye color mutants as therapeutic tools for Huntington disease

(2012) Edward W. Green et al.   FLY

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Targeting Neuro-Inflammatory Cytokines and Oxidative Stress by Minocycline Attenuates Quinolinic-Acid-Induced Huntington’s Disease-Like Symptoms in Rats

(2012) Harikesh Kalonia et al.   NEUROTOXICITY RESEARCH

The Antioxidant Role of Xanthurenic Acid in the Aedes aegypti Midgut during Digestion of a Blood Meal

(2012) Vitor L. A. Lima et al.   PLoS One

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Chemiluminometric evaluation of melatonin and selected melatonin precursors’ interaction with reactive oxygen and nitrogen species

(2011) Joanna Harasimowicz et al.   ANALYTICAL BIOCHEMISTRY

CXCR3 ligands promote expression of functional indoleamine 2,3-dioxygenase in basal cell carcinoma keratinocytes

(2011) B.K.K. Lo et al.   BRITISH JOURNAL OF DERMATOLOGY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats

(2011) Nady Braidy et al.   FEBS Journal

l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species

(2011) Hyunkeun Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe3+ and NADPH

(2011) Katsuyuki Minakata et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro

(2011) Erin K. Stachowski et al.   JOURNAL OF NEURAL TRANSMISSION

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2

(2010) Christopher Jonathan Daraius Austin et al.   AMINO ACIDS

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

(2010) Sun-Mi Lee et al.   IMMUNOLOGY LETTERS

Antiperoxidative and Antiinflammatory Effect of Sida Cordifolia Linn. on Quinolinic Acid Induced Neurotoxicity

(2010) S. S. Swathy et al.   NEUROCHEMICAL RESEARCH

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry

(2010) Å. Konradsson-Geuken et al.   NEUROSCIENCE

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Antioxidant activity of tryptophan in rats under experimental endotoxic shock

(2009) Oscar Kurt Bitzer-Quintero et al.   BIOMEDICINE & PHARMACOTHERAPY

Impact of co administration of selenium and quinolinic acid in the rat's brain

(2009) S. Sreekala et al.   BRAIN RESEARCH

Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

(2009) A. Zmarowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The crystal structure of human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis

(2009) Silvia Garavaglia et al.   FEBS Journal

The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

(2009) Hui-Qiu Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

Tryptophan Released From Mother's Milk Has Antioxidant Properties

(2009) Apollinaire Tsopmo et al.   PEDIATRIC RESEARCH

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

(2009) Robert Schwarcz et al.   PROGRESS IN NEUROBIOLOGY

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

(2008) Qian Han et al.   BIOSCIENCE REPORTS

Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli

(2008) Alessandra Paglino et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, andS-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

(2008) Amichand Dairam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l-carnitine

(2008) Daniela Silva-Adaya et al.   JOURNAL OF NEUROCHEMISTRY

Xanthurenic acid distribution, transport, accumulation and release in the rat brain

(2008) Serge Gobaille et al.   JOURNAL OF NEUROCHEMISTRY

Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species

(2008) Fabienne Peyrot et al.   JOURNAL OF PINEAL RESEARCH

Tryptophan administration induces oxidative stress in brain cortex of rats

(2008) Luciane Rosa Feksa et al.   METABOLIC BRAIN DISEASE

Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III

(2008) Q. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

(2007) L GREGOIRE et al.   BEHAVIOURAL BRAIN RESEARCH

GPR35 is a functional receptor in rat dorsal root ganglion neurons

(2007) Hiroyuki Ohshiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS