标题
Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
作者
关键词
-
出版物
Frontiers in Immunology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-10-30
DOI
10.3389/fimmu.2019.02565
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
- (2019) Michael Platten et al. NATURE REVIEWS DRUG DISCOVERY
- Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
- (2018) Leandro Z. Agudelo et al. Cell Metabolism
- Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
- (2018) Ling Liu et al. Cell Metabolism
- Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity
- (2018) Mohamad El-Zaatari et al. GASTROENTEROLOGY
- Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health
- (2018) Ludivine Laurans et al. NATURE MEDICINE
- Single cell analysis of kynurenine and System L amino acid transport in T cells
- (2018) Linda V. Sinclair et al. Nature Communications
- Immunological alterations in frail older adults: A cross sectional study
- (2018) Vanessa Valdiglesias et al. EXPERIMENTAL GERONTOLOGY
- De novo NAD+ biosynthetic impairment in acute kidney injury in humans
- (2018) Ali Poyan Mehr et al. NATURE MEDICINE
- Inflammaging: a new immune–metabolic viewpoint for age-related diseases
- (2018) Claudio Franceschi et al. Nature Reviews Endocrinology
- Microbial tryptophan catabolites in health and disease
- (2018) Henrik M. Roager et al. Nature Communications
- The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study
- (2018) Stein-Erik Hafstad Solvang et al. BRAIN BEHAVIOR AND IMMUNITY
- Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution
- (2018) Jonathan D. Proto et al. IMMUNITY
- De novo NAD+ synthesis enhances mitochondrial function and improves health
- (2018) Elena Katsyuba et al. NATURE
- Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation
- (2018) Paras S. Minhas et al. NATURE IMMUNOLOGY
- Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
- (2018) L. A. Ramos-Chávez et al. Oxidative Medicine and Cellular Longevity
- The integration of inflammaging in age-related diseases
- (2018) Tamas Fulop et al. SEMINARS IN IMMUNOLOGY
- GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk
- (2017) Margery A. Connelly et al. Journal of Translational Medicine
- Non-conventional features of peripheral serotonin signalling — the gut and beyond
- (2017) Stephanie N. Spohn et al. Nature Reviews Gastroenterology & Hepatology
- Inhibition of acute lethal pulmonary inflammation by the IDO–AhR pathway
- (2017) Soung-Min Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
- (2017) Igor Cervenka et al. SCIENCE
- Inflammaging and ‘Garb-aging’
- (2017) Claudio Franceschi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- NAD + in Aging: Molecular Mechanisms and Translational Implications
- (2017) Evandro F. Fang et al. TRENDS IN MOLECULAR MEDICINE
- Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study
- (2017) Manuela J. Rist et al. PLoS One
- The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis
- (2017) Roland Baumgartner et al. CYTOKINE
- Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality
- (2016) Hui Zuo et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice
- (2016) Nathaniel S. Woodling et al. BRAIN
- Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults
- (2016) Oana M Deac et al. JOURNAL OF NUTRITION
- Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
- (2016) Carlo Breda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The aryl hydrocarbon receptor promotes aging phenotypes across species
- (2016) Anna Eckers et al. Scientific Reports
- Functional metagenomic profiling of intestinal microbiome in extreme ageing
- (2016) Simone Rampelli et al. Aging-US
- Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
- (2015) Clare Edwards et al. BMC GENETICS
- Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity
- (2015) Siming Ma et al. Cell Metabolism
- Role of indoleamine 2,3-dioxygenase in health and disease
- (2015) Amanda W.S. Yeung et al. CLINICAL SCIENCE
- Amino Acid Metabolism Inhibits Antibody-Driven Kidney Injury by Inducing Autophagy
- (2015) Kapil Chaudhary et al. JOURNAL OF IMMUNOLOGY
- MARK-AGE biomarkers of ageing
- (2015) Alexander Bürkle et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
- (2015) Xiaodi Su et al. NATURE IMMUNOLOGY
- The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity
- (2015) Buvana Ravishankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development
- (2015) Jennifer E. Cole et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of systemic energy homeostasis by serotonin in adipose tissues
- (2015) Chang-Myung Oh et al. Nature Communications
- You Are What You Host: Microbiome Modulation of the Aging Process
- (2014) Caroline Heintz et al. CELL
- Regulatory T Cells and the Immune Aging Process: A Mini-Review
- (2014) Ann Jagger et al. GERONTOLOGY
- Aryl hydrocarbon receptor control of a disease tolerance defence pathway
- (2014) Alban Bessede et al. NATURE
- Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis
- (2014) Justin D Crane et al. NATURE MEDICINE
- Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice
- (2014) Francesco Fazio et al. NEUROPHARMACOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
- (2013) Ana P. Gomes et al. CELL
- A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study
- (2013) D. Theofylaktopoulou et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells
- (2013) Terry-Ann Curran et al. IMMUNOBIOLOGY
- Neopterin and kynurenine–tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study
- (2013) Gerhard Sulo et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- IDO1 Plays an Immunosuppressive Role in 2,4,6-Trinitrobenzene Sulfate-Induced Colitis in Mice
- (2013) M. Takamatsu et al. JOURNAL OF IMMUNOLOGY
- Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism
- (2013) Sebastiano Collino et al. PLoS One
- Effects of Indoleamine 2,3-Dioxygenase Deficiency on High-Fat Diet-Induced Hepatic Inflammation
- (2013) Junji Nagano et al. PLoS One
- Human serum metabolic profiles are age dependent
- (2012) Zhonghao Yu et al. AGING CELL
- Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
- (2012) Tracy L. McGaha et al. IMMUNOLOGICAL REVIEWS
- Kynurenines in the mammalian brain: when physiology meets pathology
- (2012) Robert Schwarcz et al. NATURE REVIEWS NEUROSCIENCE
- Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
- (2012) B. Ravishankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
- (2012) A. T. van der Goot et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses
- (2012) David H. Munn et al. TRENDS IN IMMUNOLOGY
- IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
- (2012) Richard Metz et al. OncoImmunology
- Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms
- (2011) Lucile Capuron et al. BIOLOGICAL PSYCHIATRY
- Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
- (2011) Daniel Zwilling et al. CELL
- The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease
- (2011) Susanna Campesan et al. CURRENT BIOLOGY
- Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
- (2011) Nady Braidy et al. FEBS Journal
- Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
- (2011) Maria T Pallotta et al. NATURE IMMUNOLOGY
- An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
- (2010) J. D. Mezrich et al. JOURNAL OF IMMUNOLOGY
- Kynurenine is an endothelium-derived relaxing factor produced during inflammation
- (2010) Yutang Wang et al. NATURE MEDICINE
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
- (2010) N. T. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase
- (2008) Christoph F.A. Vogel et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Origin and physiological roles of inflammation
- (2008) Ruslan Medzhitov NATURE
- SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
- (2008) C. Orabona et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Indoleamine 2,3‐dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study
- (2008) P. Niinisalo et al. SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
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