Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

(2014) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: CD4 T Cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling

(2014) M. Kashyap et al.   JOURNAL OF IMMUNOLOGY

Autoantigen-Specific IL-10-Transduced T Cells Suppress Chronic Arthritis by Promoting the Endogenous Regulatory IL-10 Response

(2014) T. Guichelaar et al.   JOURNAL OF IMMUNOLOGY

Assessment of Bet v 1-Specific CD4+ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers

(2014) L. Van Overtvelt et al.   JOURNAL OF IMMUNOLOGY

Suppression of B-cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides

(2013) C. Sackesen et al.   ALLERGY

FcεRI stimulation promotes the differentiation of histamine receptor 1-expressing inflammatory macrophages

(2013) N. Novak et al.   ALLERGY

The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells

(2013) J-S Delisle et al.   GENES AND IMMUNITY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report

(2013) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation

(2013) Abel Suárez-Fueyo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Immunomodulation by Bifidobacterium infantis 35624 in the Murine Lamina Propria Requires Retinoic Acid-Dependent and Independent Mechanisms

(2013) Patrycja Konieczna et al.   PLoS One

Mechanisms of peripheral tolerance to allergens

(2012) O. U. Soyer et al.   ALLERGY

Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

(2012) Y. C. Yang et al.   ALLERGY

Davos Declaration: Allergy as a global problem

(2012) J. Ring   ALLERGY

TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection

(2012) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of angiogenesis by IL-32: Possible role in asthma

(2012) Norbert Meyer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

(2012) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2

(2012) Natalija Novak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

(2012) Umut Can Kücüksezer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Can we produce true tolerance in patients with food allergy?

(2012) M. Cecilia Berin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evidence for a stepwise program of extrathymic T cell development within the human tonsil

(2012) Susan McClory et al.   JOURNAL OF CLINICAL INVESTIGATION

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Therapies for allergic inflammation: refining strategies to induce tolerance

(2012) Cezmi A Akdis   NATURE MEDICINE

Optimal Isolation of Functional Foxp3+ Induced Regulatory T Cells Using DEREG Mice

(2012) Abdul Mannan Baru et al.   PLoS One

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Induction of Tolerance via the Sublingual Route: Mechanisms and Applications

(2011) Philippe Moingeon et al.   Clinical & Developmental Immunology

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

(2011) Y Gao et al.   GENES AND IMMUNITY

Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children

(2011) M Janzi et al.   GENES AND IMMUNITY

FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity

(2011) S L Mackey-Cushman et al.   GENES AND IMMUNITY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

The many routes of dendritic cells to ensure immune regulation

(2011) Oscar Palomares et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bet v 1–specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1–specific T-cell effector function in an activation-dependent manner

(2011) Klaus G. Schmetterer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy

(2011) Cezmi A. Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

(2011) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

(2011) Oscar Palomares et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice

(2011) L Mascarell et al.   Mucosal Immunology

Functional Transforming Growth Factor-β Receptor Type II Expression by CD4+ T Cells in Peyer's Patches Is Essential for Oral Tolerance Induction

(2011) Rebekah S. Gilbert et al.   PLoS One

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

(2011) Tomoyuki Yamaguchi et al.   SEMINARS IN IMMUNOLOGY

Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy

(2010) Joonyong Noh et al.   CELLULAR IMMUNOLOGY

Role of Treg in immune regulation of allergic diseases

(2010) Oscar Palomares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells

(2010) W Hansen et al.   GENES AND IMMUNITY

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

(2010) A V Grant et al.   GENES AND IMMUNITY

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

(2010) Valentina Pacciani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

(2010) Alicia N. McMurchy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and molecular basis for the regulation of inflammation by TGF- 

(2010) A. Yoshimura et al.   JOURNAL OF BIOCHEMISTRY

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

T regulatory cells and their counterparts: masters of immune regulation

(2009) C. Ozdemir et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human rhinoviruses induce IL-35-producing Tregviainduction of B7-H1 (CD274) and sialoadhesin (CD169) on DC

(2009) Maria Seyerl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional analysis of −351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-κB

(2009) S B Early et al.   GENES AND IMMUNITY

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells

(2009) Silvia Gregori et al.   HUMAN IMMUNOLOGY

Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+inducible regulatory T cells

(2009) Jinfang Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+inducible regulatory T cells

(2009) Sven Klunker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique Phenotype of Human Tonsillar and In Vitro-Induced FOXP3+CD8+ T Cells

(2009) K. Siegmund et al.   JOURNAL OF IMMUNOLOGY

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

(2009) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors

(2008) F. Meiler et al.   ALLERGY

Heterogeneous response of nasal and lung fibroblasts to transforming growth factor-β1

(2008) M. Nonaka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

(2008) Giorgia Gri et al.   IMMUNITY

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

(2008) Yasmine Belkaid et al.   IMMUNITY

CD4+T-regulatory cells: toward therapy for human diseases

(2008) Sarah E. Allan et al.   IMMUNOLOGICAL REVIEWS

Viral sensors: diversity in pathogen recognition

(2008) Stephen A. McCartney et al.   IMMUNOLOGICAL REVIEWS

Grass pollen immunotherapy induces Foxp3-expressing CD4+CD25+ cells in the nasal mucosa

(2008) Suzana Radulovic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer

(2007) Alessandra Battaglia et al.   IMMUNOLOGY