Contextual determinants of TGFβ action in development, immunity and cancer

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Blocking extracellular activation of myostatin as a strategy for treating muscle wasting

(2018) M. Pirruccello-Straub et al.   Scientific Reports

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

(2017) Peter M. van der Kraan   Nature Reviews Rheumatology

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling

(2017) Christian Siebold et al.   TRENDS IN CELL BIOLOGY

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

(2017) Alan C. Mullen et al.   Cold Spring Harbor Perspectives in Biology

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

(2017) Shomyseh Sanjabi et al.   Cold Spring Harbor Perspectives in Biology

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

(2017) Pau Martin-Malpartida et al.   Nature Communications

In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors

(2017) Andrew C. Nelson et al.   Cell Reports

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

(2017) Jose L Pelliccia et al.   eLife

Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

(2017) Tessa G Montague et al.   eLife

Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

(2017) Brent W Bisgrove et al.   eLife

Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment

(2017) Sadna Budhu et al.   Science Signaling

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Dissection of transcriptional andcis‐regulatory control of differentiation in human pancreatic cancer

(2016) Giuseppe R Diaferia et al.   EMBO JOURNAL

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

BMP signalling in skeletal development, disease and repair

(2016) Valerie S. Salazar et al.   Nature Reviews Endocrinology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

(2016) Aristidis Moustakas et al.   Journal of Clinical Medicine

GDF-5 can act as a context-dependent BMP-2 antagonist

(2015) Uwe Klammert et al.   BMC BIOLOGY

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Activin/Nodal signalling in stem cells

(2015) S. Pauklin et al.   DEVELOPMENT

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

(2015) T. Faial et al.   DEVELOPMENT

Genomewide Comprehensive Analysis Reveals Critical Cooperation Between Smad and c-Fos in RANKL-Induced Osteoclastogenesis

(2015) Yasunori Omata et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SMADs and YAP Compete to Control Elongation of β-Catenin:LEF-1-Recruited RNAPII during hESC Differentiation

(2015) Conchi Estarás et al.   MOLECULAR CELL

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

(2015) Denes Hnisz et al.   MOLECULAR CELL

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells

(2015) Mandayam O. Nandan et al.   Stem Cell Research

Structural determinants of Smad function in TGF-β signaling

(2015) Maria J. Macias et al.   TRENDS IN BIOCHEMICAL SCIENCES

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

(2014) Nermi L. Parrow et al.   Annual Review of Nutrition

BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages

(2014) Maria Genander et al.   Cell Stem Cell

The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways

(2014) Lina Herhaus et al.   CELLULAR SIGNALLING

Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast

(2014) Liang Tso Sun et al.   DEVELOPMENTAL BIOLOGY

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

Regulatory crosstalk between lineage-survival oncogenesKLF5, GATA4andGATA6cooperatively promotes gastric cancer development

(2014) Na-Yu Chia et al.   GUT

The DAN family: Modulators of TGF-β signaling and beyond

(2014) Kristof Nolan et al.   PROTEIN SCIENCE

TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation

(2014) Tessa Gaarenstroom et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Genetic Basis of Aortic Aneurysm

(2014) M. E. Lindsay et al.   Cold Spring Harbor Perspectives in Medicine

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Towards an understanding of cell-specific functions of signal-dependent transcription factors

(2013) Dawn X Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

KLF5 Activates MicroRNA 200 Transcription To Maintain Epithelial Characteristics and Prevent Induced Epithelial-Mesenchymal Transition in Epithelial Cells

(2013) B. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis

(2013) G A Bjerke et al.   ONCOGENE

Maintenance of pluripotency in mouse ES cells without Trp53

(2013) Masaki Shigeta et al.   Scientific Reports

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation

(2012) Amar M. Singh et al.   Cell Stem Cell

The Harmonies Played by TGF-β in Stem Cell Biology

(2012) Naoki Oshimori et al.   Cell Stem Cell

Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer

(2012) Christine D. Reid et al.   DEVELOPMENTAL BIOLOGY

BMP signaling in vascular diseases

(2012) Jie Cai et al.   FEBS LETTERS

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads

(2012) Sirio Dupont et al.   FEBS LETTERS

Roles of activin family in pancreatic development and homeostasis

(2012) Ezra Wiater et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetics of Mammalian Reproduction: Modeling the End of the Germline

(2011) Martin M. Matzuk et al.   Annual Review of Physiology

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

A Poised Chromatin Platform for TGF-β Access to Master Regulators

(2011) Qiaoran Xi et al.   CELL

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

(2011) Eirini Trompouki et al.   CELL

Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs

(2011) Si Wan Kim et al.   DEVELOPMENTAL BIOLOGY

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Pluripotency factors regulate definitive endoderm specification through eomesodermin

(2011) A. K. K. Teo et al.   GENES & DEVELOPMENT

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

(2011) Masato Morikawa et al.   NUCLEIC ACIDS RESEARCH

Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition

(2010) Samy Lamouille et al.   CELLS TISSUES ORGANS

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

Smad2 Positively Regulates the Generation of Th17 Cells

(2010) Gustavo J. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development

(2010) T. Takimoto et al.   JOURNAL OF IMMUNOLOGY

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors

(2010) Nithya BabuRajendran et al.   NUCLEIC ACIDS RESEARCH

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma

(2009) Silvia Peñuelas et al.   CANCER CELL

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Dlx3 is a crucial regulator of hair follicle differentiation and cycling

(2008) J. Hwang et al.   DEVELOPMENT

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology