Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction

(2017) Julia Hesse et al.   FASEB JOURNAL

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche

(2017) Fotis Asimakopoulos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

(2017) John H. Rosenberg et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

TLRs Go Linear – On the Ubiquitin Edge

(2017) Julia Zinngrebe et al.   TRENDS IN MOLECULAR MEDICINE

Interleukin 37 promotes angiogenesis through TGF-β signaling

(2017) Mengmeng Zhao et al.   Scientific Reports

Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

(2017) Linda Koehler et al.   Scientific Reports

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

(2016) C. Hope et al.   BLOOD

Cellular and molecular regulation of innate inflammatory responses

(2016) Juan Liu et al.   Cellular & Molecular Immunology

Molecular mechanisms involved in dendritic cell dysfunction in cancer

(2016) Michael Tang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dynamic structure of plasma fibronectin

(2016) Lisa M. Maurer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The cellular and signalling alterations conducted by TGF-β contributing to renal fibrosis

(2016) Génesis Vega et al.   CYTOKINE

N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro

(2016) Christoph Lipps et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

(2016) Neil A. Turner   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

(2016) Louise Tzung-Harn Hsieh et al.   MATRIX BIOLOGY

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice

(2016) Judyta K. Juranek et al.   Frontiers in Cellular Neuroscience

Tenascin-C drives persistence of organ fibrosis

(2016) Swati Bhattacharyya et al.   Nature Communications

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4Significance

(2015) Prakash Doddapattar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

(2015) Paul O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?

(2015) Brooke Farrugia et al.   MOLECULES

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid

(2015) Ali Alquraini et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling

(2015) Michael Tang et al.   Cell Reports

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin

(2015) Afnan Al-Sharif et al.   Arthritis & Rheumatology

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species

(2015) Marta Krystyna Kosinska et al.   PLoS One

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

(2014) Madalina V. Nastase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

How the Innate Immune System Senses Trouble and Causes Trouble

(2014) T. Hato et al.   Clinical Journal of the American Society of Nephrology

Soluble biglycan as a biomarker of inflammatory renal diseases

(2014) Louise Tzung-Harn Hsieh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation

(2014) Anna Jonas et al.   JOURNAL OF CLINICAL INVESTIGATION

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease

(2014) Mary Y. Chang et al.   MATRIX BIOLOGY

Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury

(2014) Kristin Moreth et al.   MATRIX BIOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the Innate Immune Response by Fibronectin: Synergism between the III-1 and EDA Domains

(2014) Rhiannon Kelsh et al.   PLoS One

Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4

(2014) Katharine J. Goodall et al.   PLoS One

Human TLR10 is an anti-inflammatory pattern-recognition receptor

(2014) Marije Oosting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronan, a Crucial Regulator of Inflammation

(2014) Aaron C. Petrey et al.   Frontiers in Immunology

Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

(2013) Ding Xu et al.   ACS Chemical Biology

Elevation of S100 calcium binding protein A9 in sputum of neutrophilic inflammation in severe uncontrolled asthma

(2013) Tae-Hyeong Lee et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Versatile role of heparanase in inflammation

(2013) Rachel Goldberg et al.   MATRIX BIOLOGY

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

(2013) Jinyang Zeng-Brouwers et al.   MATRIX BIOLOGY

RAGE and TLRs: Relatives, friends or neighbours?

(2013) Zaridatul Aini Ibrahim et al.   MOLECULAR IMMUNOLOGY

Tenascin C Promiscuously Binds Growth Factors via Its Fifth Fibronectin Type III-Like Domain

(2013) Laura De Laporte et al.   PLoS One

Clinical significance of serum hyaluronan in chronic fibrotic interstitial pneumonia

(2013) Yayoi Inokoshi et al.   RESPIROLOGY

Targeting the TLR Co-Receptor CD14 with TLR2-Derived Peptides Modulates Immune Responses to Pathogens

(2013) A.-C. Raby et al.   Science Translational Medicine

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

(2013) David Anak Simon Davis et al.   Frontiers in Immunology

Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation

(2012) Kristin Moreth et al.   CELL CYCLE

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Receptor for Advanced Glycation End Products (RAGE) Functions as Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or Sulfated Glycosaminoglycans Deliveredin VivoInhibit Pulmonary Metastasis of Tumor Cells

(2012) Shuji Mizumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 v 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1

(2012) T. Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes

(2012) Ravichandran Ramasamy et al.   VASCULAR PHARMACOLOGY

Endogenous Control of Immunity against Infection: Tenascin-C Regulates TLR4-Mediated Inflammation via MicroRNA-155

(2012) Anna M. Piccinini et al.   Cell Reports

Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4

(2011) Julie S. Lefebvre et al.   ARTHRITIS AND RHEUMATISM

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Heparan Sulfate Is Essential for High Mobility Group Protein 1 (HMGB1) Signaling by the Receptor for Advanced Glycation End Products (RAGE)

(2011) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor

(2011) Nidhi Sofat et al.   Journal of Innate Immunity

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

(2011) R. Merline et al.   Science Signaling

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging

(2010) Shi Fang Yan et al.   BIOCHEMICAL PHARMACOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Homodimerization Is Essential for the Receptor for Advanced Glycation End Products (RAGE)-mediated Signal Transduction

(2010) Hongliang Zong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation Anergy in Human Intestinal Macrophages Is Due to Smad-induced IκBα Expression and NF-κB Inactivation

(2010) Lesley E. Smythies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD14 is a coreceptor of Toll-like receptors 7 and 9

(2010) Christoph L. Baumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Ligation of TLR2 by Versican: A Link Between Inflammation and Metastasis

(2009) Wei Wang et al.   ARCHIVES OF MEDICAL RESEARCH

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)

(2008) Jingjing Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS-induced up-regulation of TGF-β receptor 1 is associated with TNF-α expression in human monocyte-derived macrophages

(2008) Yan Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Immune system in renal injury and repair: Burning the candle from both ends?

(2008) M GOLIGORSKY   PHARMACOLOGICAL RESEARCH

Identification, classification, and expression of RAGE gene splice variants

(2007) Barry I. Hudson et al.   FASEB JOURNAL