Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Spartan deficiency causes genomic instability and progeroid phenotypes

(2014) Reeja S. Maskey et al.   Nature Communications

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Chronic rapamycin treatment or lack ofS6K1does not reduce ribosome activity in vivo

(2013) Michael G Garelick et al.   CELL CYCLE

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

(2013) Darren J. Baker et al.   Cell Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains

(2012) R. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of ROR t Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

(2012) N. R. Blatner et al.   Science Translational Medicine

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

(2012) Tobias Wijshake et al.   PLoS Genetics

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Ageing-induced decline in physical endurance in mice is associated with decrease in cardiac SUR2A and increase in cardiac susceptibility to metabolic stress: therapeutic prospects for up-regulation of SUR2A

(2010) Rajni Sudhir et al.   BIOGERONTOLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Apoptosis of Hippocampal Pyramidal Neurons Is Virus Independent in a Mouse Model of Acute Neurovirulent Picornavirus Infection

(2009) Eric J. Buenz et al.   AMERICAN JOURNAL OF PATHOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

The Aging Cardiomyocyte: A Mini-Review

(2008) D. Bernhard et al.   GERONTOLOGY

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL