Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

(2010) Jaehyouk Lee et al.   Molecular Cancer

Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

(2010) Vidya Ganapathy et al.   Molecular Cancer

Assessment of Renal Fibrosis with Diffusion-weighted MR Imaging: Study with Murine Model of Unilateral Ureteral Obstruction

(2010) Osamu Togao et al.   RADIOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho

(2009) S.-K. Cha et al.   MOLECULAR PHARMACOLOGY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

(2009) I Wolf et al.   ONCOGENE

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons

(2008) S. John Weroha et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

(2008) Toru Kawai et al.   LABORATORY INVESTIGATION

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

(2008) S.-K. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA