TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

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The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling

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Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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NOTCH1 mediates a switch between two distinct secretomes during senescence

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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

(2016) Peng Ru et al.   Cell Reports

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(2016) Steven W. Criscione et al.   Science Advances

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

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The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence

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MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease

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Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair

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Senescence-associated lncRNAs: senescence-associated long noncoding RNAs

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Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

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Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

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MicroRNAs in age-related diseases

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Transforming Growth Factor β-regulated MicroRNA-29a Promotes Angiogenesis through Targeting the Phosphatase and Tensin Homolog in Endothelium

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MicroRNA-34a regulates cardiac ageing and function

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Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

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Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

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(2013) Steve Horvath   GENOME BIOLOGY

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(2012) Judith Campisi   Annual Review of Physiology

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Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

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Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

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Targeting the TGFβ signalling pathway in disease

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Non-coding RNAs as regulators of gene expression and epigenetics

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Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

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Pervasive roles of microRNAs in cardiovascular biology

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MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

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The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ

(2011) Feng Ma et al.   NATURE IMMUNOLOGY

Fra-2 mediates oxygen-sensitive induction of transforming growth factor β in cardiac fibroblasts

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Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

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Role of A-type lamins in signaling, transcription, and chromatin organization

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b

(2008) Jin He et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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