Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
出版年份 2020 全文链接
标题
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
作者
关键词
-
出版物
Science China-Life Sciences
Volume 63, Issue 7, Pages 953-985
出版商
Springer Science and Business Media LLC
发表日期
2020-06-16
DOI
10.1007/s11427-020-1702-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Rett syndrome-causing mutations compromise MeCP2-mediated liquid–liquid phase separation of chromatin
- (2020) Liang Wang et al. CELL RESEARCH
- The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy
- (2020) Anastasia C. Murthy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The CBX family of proteins in transcriptional repression and memory
- (2020) Jongmin Kim et al. JOURNAL OF BIOSCIENCES
- Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates
- (2020) Akinori Yamasaki et al. MOLECULAR CELL
- Phase separation of the C. elegans Polycomb protein SOP-2 is modulated by RNA and sumoylation
- (2020) Wenyan Qu et al. Protein & Cell
- Liquid-liquid phase separation drives skin barrier formation
- (2020) Felipe Garcia Quiroz et al. SCIENCE
- RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation
- (2019) Xiandeng Wu et al. MOLECULAR CELL
- Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis
- (2019) Zheng Wang et al. TRENDS IN CELL BIOLOGY
- Stoichiometry controls activity of phase-separated clusters of actin signaling proteins
- (2019) Lindsay B. Case et al. SCIENCE
- The C-Terminal Domain of RNA Polymerase II Is a Multivalent Targeting Sequence that Supports Drosophila Development with Only Consensus Heptads
- (2019) Feiyue Lu et al. MOLECULAR CELL
- Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition
- (2019) Peng Wu et al. MOLECULAR CELL
- PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
- (2019) Yongjia Duan et al. CELL RESEARCH
- FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
- (2019) Lara Marrone et al. ACTA NEUROPATHOLOGICA
- Regulation of Transmembrane Signaling by Phase Separation
- (2019) Lindsay B. Case et al. Annual Review of Biophysics
- ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility
- (2019) Roni H.G. Wright et al. TRENDS IN BIOCHEMICAL SCIENCES
- Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle
- (2019) Chet Huan Oon et al. eLife
- The Cytoskeleton—A Complex Interacting Meshwork
- (2019) Hohmann et al. Cells
- Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2
- (2019) Aaron J. Plys et al. GENES & DEVELOPMENT
- Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain
- (2019) Anastasia C. Murthy et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The nucleolus functions as a phase-separated protein quality control compartment
- (2019) F. Frottin et al. SCIENCE
- A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes
- (2019) Chun So et al. SCIENCE
- Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
- (2019) Xinrui Gui et al. Nature Communications
- Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis
- (2019) Riccardo De Santis et al. Cell Reports
- Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization
- (2019) Kalyn Kono et al. eLife
- RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
- (2019) Ya-Cheng Liao et al. CELL
- Microtubule minus-end regulation at a glance
- (2019) Anna Akhmanova et al. JOURNAL OF CELL SCIENCE
- Interplay between Short-Range Attraction and Long-Range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein–RNA Complexes
- (2019) Ibraheem Alshareedah et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
- (2019) Liang Wang et al. MOLECULAR CELL
- Enhancer Features that Drive Formation of Transcriptional Condensates
- (2019) Krishna Shrinivas et al. MOLECULAR CELL
- Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus
- (2019) Run-Wen Yao et al. MOLECULAR CELL
- Organization and regulation of gene transcription
- (2019) Patrick Cramer NATURE
- DEAD-box ATPases are global regulators of phase-separated organelles
- (2019) Maria Hondele et al. NATURE
- Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission
- (2019) Menglong Zeng et al. NEURON
- Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching
- (2019) Nicole O. Taylor et al. BIOPHYSICAL JOURNAL
- Organization of Chromatin by Intrinsic and Regulated Phase Separation
- (2019) Bryan A. Gibson et al. CELL
- Protein phase separation in mitosis
- (2019) Ashish Kumar Tiwary et al. CURRENT OPINION IN CELL BIOLOGY
- Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications
- (2019) Zhe Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Calibration between trigger and color: Neutralization of a genetically encoded coulombic switch and dynamic arrest precisely tune reflectin assembly
- (2019) Robert Levenson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation
- (2019) Xiangru Huo et al. MOLECULAR CELL
- HP1 reshapes nucleosome core to promote phase separation of heterochromatin
- (2019) S. Sanulli et al. NATURE
- Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
- (2019) Sali M. K. Farhan et al. NATURE NEUROSCIENCE
- Biomolecular condensates in neurodegeneration and cancer
- (2019) Stephanie Spannl et al. TRAFFIC
- Microtubule-Associated Proteins: Structuring the Cytoskeleton
- (2019) Satish Bodakuntla et al. TRENDS IN CELL BIOLOGY
- The pause-initiation limit restricts transcription activation in human cells
- (2019) Saskia Gressel et al. Nature Communications
- Core autophagy genes and human diseases
- (2019) Yan G Zhao et al. CURRENT OPINION IN CELL BIOLOGY
- Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression
- (2019) Danfeng Cai et al. NATURE CELL BIOLOGY
- The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation
- (2018) Adam G. Larson et al. BIOCHEMISTRY
- Formation of Chromatin Subcompartments by Phase Separation
- (2018) Fabian Erdel et al. BIOPHYSICAL JOURNAL
- Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
- (2018) Takuya Yoshizawa et al. CELL
- Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
- (2018) Mario Hofweber et al. CELL
- Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
- (2018) Sebastian Markmiller et al. CELL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
- (2018) Lin Guo et al. CELL
- FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
- (2018) Seema Qamar et al. CELL
- Ubiquitin-induced phase separation of p62/SQSTM1
- (2018) Lina Herhaus et al. CELL RESEARCH
- Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
- (2018) Daxiao Sun et al. CELL RESEARCH
- Formation and maturation of autophagosomes in higher eukaryotes: a social network
- (2018) Yan G Zhao et al. CURRENT OPINION IN CELL BIOLOGY
- p62 filaments capture and present ubiquitinated cargos for autophagy
- (2018) Gabriele Zaffagnini et al. EMBO JOURNAL
- Tau protein liquid–liquid phase separation can initiate tau aggregation
- (2018) Susanne Wegmann et al. EMBO JOURNAL
- 3D structure determination of amyloid fibrils using solid-state NMR spectroscopy
- (2018) Antoine Loquet et al. METHODS
- Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation
- (2018) Veronica H. Ryan et al. MOLECULAR CELL
- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- Eukaryotic core promoters and the functional basis of transcription initiation
- (2018) Vanja Haberle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
- (2018) Feng Luo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular epidemiological study of familial amyotrophic lateral sclerosis in Japanese population by whole-exome sequencing and identification of novel HNRNPA1 mutation
- (2018) Hiroya Naruse et al. NEUROBIOLOGY OF AGING
- RNA buffers the phase separation behavior of prion-like RNA binding proteins
- (2018) Shovamayee Maharana et al. SCIENCE
- Near-atomic model of microtubule-tau interactions
- (2018) Elizabeth H. Kellogg et al. SCIENCE
- A liquid phase of synapsin and lipid vesicles
- (2018) Dragomir Milovanovic et al. SCIENCE
- Coactivator condensation at super-enhancers links phase separation and gene control
- (2018) Benjamin R. Sabari et al. SCIENCE
- Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
- (2018) Won-Ki Cho et al. SCIENCE
- Atomic force microscopy as a tool for assessing the cellular elasticity and adhesiveness to identify cancer cells and tissues
- (2018) Joanna Zemła et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Organization and Function of Non-dynamic Biomolecular Condensates
- (2018) Jeffrey B. Woodruff et al. TRENDS IN BIOCHEMICAL SCIENCES
- TCR Signaling: Mechanisms of Initiation and Propagation
- (2018) Adam H. Courtney et al. TRENDS IN BIOCHEMICAL SCIENCES
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division
- (2018) Zelin Shan et al. Nature Communications
- A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
- (2018) Maneka Chitiprolu et al. Nature Communications
- Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
- (2018) Feng Luo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts
- (2018) Matthew Robert Hannaford et al. eLife
- A compartmentalized signaling network mediates crossover control in meiosis
- (2018) Liangyu Zhang et al. eLife
- Heterochromatin: Guardian of the Genome
- (2018) Aniek Janssen et al. Annual Review of Cell and Developmental Biology
- Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity
- (2018) Menglong Zeng et al. CELL
- mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation
- (2018) Gangming Zhang et al. CELL
- Emerging mechanisms of asymmetric stem cell division
- (2018) Zsolt G. Venkei et al. JOURNAL OF CELL BIOLOGY
- Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
- (2018) Jill J. Bouchard et al. MOLECULAR CELL
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
- (2018) Leeanne McGurk et al. MOLECULAR CELL
- Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
- (2018) Huasong Lu et al. NATURE
- RNA polymerase II clustering through carboxy-terminal domain phase separation
- (2018) Marc Boehning et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
- (2018) Ann Boija et al. CELL
- A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions
- (2018) Weirui Ma et al. CELL
- Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation
- (2018) Shuai Zhao et al. CELL RESEARCH
- Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation
- (2018) Roubina Tatavosian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics
- (2018) Mario Hofweber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagosome maturation: An epic journey from the ER to lysosomes
- (2018) Yan G. Zhao et al. JOURNAL OF CELL BIOLOGY
- p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
- (2018) Alberto Danieli et al. JOURNAL OF CELL SCIENCE
- Actin–microtubule crosstalk in cell biology
- (2018) Marileen Dogterom et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps
- (2018) Louise M. Jawerth et al. PHYSICAL REVIEW LETTERS
- Aurora A activation in mitosis promoted by BuGZ
- (2017) Yuejia Huang et al. JOURNAL OF CELL BIOLOGY
- Actin assembly mechanisms at a glance
- (2017) Klemens Rottner et al. JOURNAL OF CELL SCIENCE
- Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division
- (2017) Wenyu Wen et al. JOURNAL OF MOLECULAR BIOLOGY
- Evolving Models of Heterochromatin: From Foci to Liquid Droplets
- (2017) Antonis Tatarakis et al. MOLECULAR CELL
- Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
- (2017) Steven Boeynaems et al. MOLECULAR CELL
- The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation
- (2017) Yan G. Zhao et al. MOLECULAR CELL
- Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation
- (2017) Sharmistha Kundu et al. MOLECULAR CELL
- Molecular biology: A liquid reservoir for silent chromatin
- (2017) Adam Klosin et al. NATURE
- Phase separation drives heterochromatin domain formation
- (2017) Amy R. Strom et al. NATURE
- Core Mediator structure at 3.4 Å extends model of transcription initiation complex
- (2017) Kayo Nozawa et al. NATURE
- Mediator structure and rearrangements required for holoenzyme formation
- (2017) Kuang-Lei Tsai et al. NATURE
- RNA phase transitions in repeat expansion disorders
- (2017) Ankur Jain et al. NATURE
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- (2017) Adam G. Larson et al. NATURE
- Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization
- (2017) Shyi-Chyi Wang et al. NATURE CELL BIOLOGY
- Biomolecular condensates: organizers of cellular biochemistry
- (2017) Salman F. Banani et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Transcellular Nanoalignment of Synaptic Function
- (2017) Thomas Biederer et al. NEURON
- TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
- (2017) Ian R. Mackenzie et al. NEURON
- Liquid behavior of cross-linked actin bundles
- (2017) Kimberly L. Weirich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATP as a biological hydrotrope
- (2017) Avinash Patel et al. SCIENCE
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- The Mediator Complex: At the Nexus of RNA Polymerase II Transcription
- (2017) Célia Jeronimo et al. TRENDS IN CELL BIOLOGY
- Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
- (2017) Ping Wang et al. Nature Communications
- Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
- (2017) Yunior Cabrales Fontela et al. Nature Communications
- Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
- (2017) Susmitha Ambadipudi et al. Nature Communications
- Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
- (2017) Amayra Hernández-Vega et al. Cell Reports
- RNA stores tau reversibly in complex coacervates
- (2017) Xuemei Zhang et al. PLOS BIOLOGY
- The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors
- (2017) Ofer Rog et al. eLife
- Signaling and Polarized Communication Across the T Cell Immunological Synapse
- (2016) Michael L. Dustin et al. Annual Review of Cell and Developmental Biology
- Are aberrant phase transitions a driver of cellular aging?
- (2016) Simon Alberti et al. BIOESSAYS
- Amyloid-like Self-Assembly of a Cellular Compartment
- (2016) Elvan Boke et al. CELL
- Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
- (2016) Menglong Zeng et al. CELL
- The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules
- (2016) Hao Wu et al. CELL
- ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure
- (2016) Saumya Jain et al. CELL
- C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
- (2016) Kyung-Ha Lee et al. CELL
- Compositional Control of Phase-Separated Cellular Bodies
- (2016) Salman F. Banani et al. CELL
- Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
- (2016) Yi Lin et al. CELL
- Coexisting Liquid Phases Underlie Nucleolar Subcompartments
- (2016) Marina Feric et al. CELL
- Genetics of Frontotemporal Dementia
- (2016) Diana A. Olszewska et al. Current Neurology and Neuroscience Reports
- Adaptation to Stressors by Systemic Protein Amyloidogenesis
- (2016) Timothy E. Audas et al. DEVELOPMENTAL CELL
- High Charge Density Coacervate Assembly via Hybrid Monte Carlo Single Chain in Mean Field Theory
- (2016) Tyler K. Lytle et al. MACROMOLECULES
- A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism
- (2016) Massimo Ganassi et al. MOLECULAR CELL
- The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes
- (2016) Zheng Wang et al. MOLECULAR CELL
- A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
- (2016) Ai-Hui Tang et al. NATURE
- Podocyte–actin dynamics in health and disease
- (2016) Luca Perico et al. Nature Reviews Nephrology
- Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling
- (2016) Jinwei Zhu et al. NATURE REVIEWS NEUROSCIENCE
- How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs
- (2016) Claudio Acuna et al. NEURON
- Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking
- (2016) Shan Shan H. Wang et al. NEURON
- Phase separation of signaling molecules promotes T cell receptor signal transduction
- (2016) Xiaolei Su et al. SCIENCE
- Biophysical characterization of organelle-based RNA/protein liquid phases using microfluidics
- (2016) Nicole Taylor et al. Soft Matter
- Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity
- (2016) Kang Zhu et al. STRUCTURE
- ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
- (2016) Alexander E. Conicella et al. STRUCTURE
- Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
- (2016) H. Broder Schmidt et al. TRENDS IN BIOCHEMICAL SCIENCES
- Phase Separation: Linking Cellular Compartmentalization to Disease
- (2016) Adriano Aguzzi et al. TRENDS IN CELL BIOLOGY
- Principles and Properties of Stress Granules
- (2016) David S.W. Protter et al. TRENDS IN CELL BIOLOGY
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic
- (2016) Joel M Swenson et al. eLife
- De novo, heterozygous, loss-of-function mutations inSYNGAP1cause a syndromic form of intellectual disability
- (2015) Michael J. Parker et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly
- (2015) Hao Jiang et al. CELL
- Quantitative Mass Spectrometry Measurements Reveal Stoichiometry of Principal Postsynaptic Density Proteins
- (2015) Mark S. Lowenthal et al. JOURNAL OF PROTEOME RESEARCH
- Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
- (2015) Yuan Lin et al. MOLECULAR CELL
- Architecture of the RNA polymerase II–Mediator core initiation complex
- (2015) C. Plaschka et al. NATURE
- Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice
- (2015) Meaghan Morris et al. NATURE NEUROSCIENCE
- Polymer physics of intracellular phase transitions
- (2015) Clifford P. Brangwynne et al. Nature Physics
- Control of microtubule organization and dynamics: two ends in the limelight
- (2015) Anna Akhmanova et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Intrinsically disordered proteins in cellular signalling and regulation
- (2015) Peter E. Wright et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tau and neurodegenerative disease: the story so far
- (2015) Khalid Iqbal et al. Nature Reviews Neurology
- Rapid Dispersion of SynGAP from Synaptic Spines Triggers AMPA Receptor Insertion and Spine Enlargement during LTP
- (2015) Yoichi Araki et al. NEURON
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
- (2015) Tetsuro Murakami et al. NEURON
- Nanoscale Distribution of Presynaptic Ca 2+ Channels and Its Impact on Vesicular Release during Development
- (2015) Yukihiro Nakamura et al. NEURON
- Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
- (2015) Harindranath Kadavath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
- (2015) Shana Elbaum-Garfinkle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential effects of Ydj1 and Sis1 on Hsp70-mediated clearance of stress granules inSaccharomyces cerevisiae
- (2015) Robert W. Walters et al. RNA
- The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division
- (2015) Min Jia et al. Nature Communications
- Soft viscoelastic properties of nuclear actin age oocytes due to gravitational creep
- (2015) Marina Feric et al. Scientific Reports
- Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules
- (2015) Sonja Kroschwald et al. eLife
- Ångström-Precision Optical Traps and Applications
- (2014) Thomas T. Perkins Annual Review of Biophysics
- Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
- (2014) Matthew T. Weirauch et al. CELL
- A Microtubule-Associated Zinc Finger Protein, BuGZ, Regulates Mitotic Chromosome Alignment by Ensuring Bub3 Stability and Kinetochore Targeting
- (2014) Hao Jiang et al. DEVELOPMENTAL CELL
- Neuropathy- and myopathy-associated mutations in human small heat shock proteins: Characteristics and evolutionary history of the mutation sites
- (2014) Rainer Benndorf et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers
- (2014) Leighton J Core et al. NATURE GENETICS
- N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity
- (2014) Gohei Nishibuchi et al. NUCLEIC ACIDS RESEARCH
- mRNP granules
- (2014) J Ross Buchan RNA Biology
- Mechanisms of functional promiscuity by HP1 proteins
- (2014) Daniele Canzio et al. TRENDS IN CELL BIOLOGY
- Phase transitions of multivalent proteins can promote clustering of membrane receptors
- (2014) Sudeep Banjade et al. eLife
- Chromatin and DNA sequences in defining promoters for transcription initiation
- (2013) Ferenc Müller et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
- (2013) J. Ross Buchan et al. CELL
- Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains
- (2013) Ilmin Kwon et al. CELL
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing
- (2013) Kyoichi Isono et al. DEVELOPMENTAL CELL
- Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans
- (2013) Sihui Li et al. MOLECULAR CELL
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells
- (2013) Marina Feric et al. NATURE CELL BIOLOGY
- Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
- (2013) Thomas C. Südhof NEURON
- Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders
- (2012) Jonathan T. Ting et al. Annual Review of Neuroscience
- Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses
- (2012) James P. Clement et al. CELL
- Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
- (2012) Masato Kato et al. CELL
- Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies
- (2012) Tina W. Han et al. CELL
- Mutations inSYNGAP1Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency
- (2012) Martin H. Berryer et al. HUMAN MUTATION
- Transient Sequestration of TORC1 into Stress Granules during Heat Stress
- (2012) Terunao Takahara et al. MOLECULAR CELL
- Phase transitions in the assembly of multivalent signalling proteins
- (2012) Pilong Li et al. NATURE
- The Presynaptic Active Zone
- (2012) Thomas C. Südhof NEURON
- Structural and energetic basis of ALS-causing mutations in the atypical proline–tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)
- (2012) Zi Chao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
- (2011) Jinwei Zhu et al. EMBO JOURNAL
- LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
- (2011) Jinwei Zhu et al. MOLECULAR CELL
- Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
- (2011) Emmanuel Eggermann et al. NATURE REVIEWS NEUROSCIENCE
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms
- (2010) Ye Tian et al. CELL
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
- (2010) Chan Gao et al. NATURE CELL BIOLOGY
- Protein aggregation diseases: pathogenicity and therapeutic perspectives
- (2010) Adriano Aguzzi et al. NATURE REVIEWS DRUG DISCOVERY
- A membranous spindle matrix orchestrates cell division
- (2010) Yixian Zheng NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A nucleator arms race: cellular control of actin assembly
- (2010) Kenneth G. Campellone et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Asymmetric cell division: recent developments and their implications for tumour biology
- (2010) Juergen A. Knoblich NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules
- (2009) Daniela Fischer et al. BIOCHEMISTRY
- SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans
- (2009) Yuxia Zhang et al. CELL
- The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors
- (2009) Jens C. Schwamborn et al. CELL
- aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division
- (2009) Scott X. Atwood et al. CURRENT BIOLOGY
- Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
- (2009) Helen Neil et al. NATURE
- Requirement for Nudel and dynein for assembly of the lamin B spindle matrix
- (2009) Li Ma et al. NATURE CELL BIOLOGY
- Spindle orientation during asymmetric cell division
- (2009) Karsten H. Siller et al. NATURE CELL BIOLOGY
- Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
- (2009) Wei Feng et al. NATURE REVIEWS NEUROSCIENCE
- Mutations inSYNGAP1in Autosomal Nonsyndromic Mental Retardation
- (2009) Fadi F. Hamdan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
- (2009) C. P. Brangwynne et al. SCIENCE
- Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization
- (2008) Frederik Wirtz-Peitz et al. CELL
- Mechanisms of Asymmetric Stem Cell Division
- (2008) Juergen A. Knoblich CELL
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods
- (2008) Wei Chen et al. Cellular and Molecular Bioengineering
- The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction
- (2008) Vladimir Pena et al. EMBO REPORTS
- Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI
- (2008) V. Erben et al. JOURNAL OF CELL SCIENCE
- Mechanisms of asymmetric cell division: flies and worms pave the way
- (2008) Pierre Gönczy NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
- (2008) R. Dixit et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More