Control of microtubule organization and dynamics: two ends in the limelight

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

(2015) Malgorzata Borowiak et al.   CELL

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

(2015) Rui Zhang et al.   CELL

CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles

(2015) Sreya Basu et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule-associated proteins control the kinetics of microtubule nucleation

(2015) Michal Wieczorek et al.   NATURE CELL BIOLOGY

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

(2015) Sandeep K Talapatra et al.   eLife

A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset

(2015) N. Tamura et al.   Biology Open

End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

(2015) Raphael Berges et al.   Oncotarget

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

(2014) Andrea E. Prota et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microtubule +TIP Protein EB1 Binds to GTP and Undergoes Dissociation from Dimer to Monomer on Binding GTP

(2014) K. K. Gireesh et al.   BIOCHEMISTRY

Promoting microtubule assembly: A hypothesis for the functional significance of the+TIP network

(2014) Kamlesh K. Gupta et al.   BIOESSAYS

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

(2014) Gregory M. Alushin et al.   CELL

Doublecortin Recognizes the Longitudinal Curvature of the Microtubule End and Lattice

(2014) Susanne Bechstedt et al.   CURRENT BIOLOGY

Spectraplakins

(2014) Sven Huelsmann et al.   CURRENT BIOLOGY

Dynamic Microtubules Catalyze Formation of Navigator-TRIO Complexes to Regulate Neurite Extension

(2014) Jeffrey van Haren et al.   CURRENT BIOLOGY

EB1 Accelerates Two Conformational Transitions Important for Microtubule Maturation and Dynamics

(2014) Sebastian P. Maurer et al.   CURRENT BIOLOGY

An EB1-Kinesin Complex Is Sufficient to Steer Microtubule Growth In Vitro

(2014) Yalei Chen et al.   CURRENT BIOLOGY

Mechanical and Geometrical Constraints Control Kinesin-Based Microtubule Guidance

(2014) Harinath Doodhi et al.   CURRENT BIOLOGY

CLASPs Are Required for Proper Microtubule Localization of End-Binding Proteins

(2014) Ashley D. Grimaldi et al.   DEVELOPMENTAL CELL

Minus-End-Directed Kinesin-14 Motors Align Antiparallel Microtubules to Control Metaphase Spindle Length

(2014) Austin J. Hepperla et al.   DEVELOPMENTAL CELL

Microtubule Minus-End Stabilization by Polymerization-Driven CAMSAP Deposition

(2014) Kai Jiang et al.   DEVELOPMENTAL CELL

The contribution of αβ-tubulin curvature to microtubule dynamics

(2014) Gary J. Brouhard et al.   JOURNAL OF CELL BIOLOGY

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

(2014) Jaime C. Fox et al.   MOLECULAR BIOLOGY OF THE CELL

Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking

(2014) Peng Xia et al.   MOLECULAR BIOLOGY OF THE CELL

Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics

(2014) Karolina Leśniewska et al.   MOLECULAR BIOLOGY OF THE CELL

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

(2014) Christian Duellberg et al.   NATURE CELL BIOLOGY

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development

(2014) Kah Wai Yau et al.   NEURON

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

(2014) A. E. Prota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin

(2014) M. C. Hendershott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide Exchange in Dimeric MCAK Induces Longitudinal and Lateral Stress at Microtubule Ends to Support Depolymerization

(2014) Kyle M. Burns et al.   STRUCTURE

Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A

(2014) Julia Häfner et al.   Nature Communications

Actin–microtubule coordination at growing microtubule ends

(2014) Magdalena Preciado López et al.   Nature Communications

The Microtubule Minus-End-Binding Protein Patronin/PTRN-1 Is Required for Axon Regeneration in C. elegans

(2014) Marian Chuang et al.   Cell Reports

The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

(2014) Jana Dorfman Marcette et al.   eLife

Reconstitution of dynein transport to the microtubule plus end by kinesin

(2014) Anthony J Roberts et al.   eLife

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

(2014) Pelin Ayaz et al.   eLife

Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2

(2013) Sabine Petry et al.   CELL

Evolving Tip Structures Can Explain Age-Dependent Microtubule Catastrophe

(2013) Courtney E. Coombes et al.   CURRENT BIOLOGY

Aurora B Inhibits MCAK Activity through a Phosphoconformational Switch that Reduces Microtubule Association

(2013) Stephanie C. Ems-McClung et al.   CURRENT BIOLOGY

The human kinesin-14 HSET tracks the tips of growing microtubules in vitro

(2013) Marcus Braun et al.   Cytoskeleton

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor

(2013) Babet van der Vaart et al.   DEVELOPMENTAL CELL

Overexpression, purification, and functional analysis of recombinant human tubulin dimer

(2013) Itsushi Minoura et al.   FEBS LETTERS

Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

(2013) Jorge G. Ferreira et al.   JOURNAL OF CELL BIOLOGY

Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation

(2013) Haifeng Wang et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of spindle positioning

(2013) Francis J. McNally   JOURNAL OF CELL BIOLOGY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Cell Cycle Regulation of Microtubule Interactomes: Multi-layered Regulation Is Critical for the Interphase/Mitosis Transition

(2013) Heather M. Syred et al.   MOLECULAR & CELLULAR PROTEOMICS

Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels

(2013) Marija Zanic et al.   NATURE CELL BIOLOGY

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

(2013) Nikita Gudimchuk et al.   NATURE CELL BIOLOGY

Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration

(2013) Jui-Hsia Weng et al.   Nature Chemical Biology

End-binding proteins sensitize microtubules to the action of microtubule-targeting agents

(2013) R. Mohan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

Structural Model for Tubulin Recognition and Deformation by Kinesin-13 Microtubule Depolymerases

(2013) Ana B. Asenjo et al.   Cell Reports

Dynactin Subunit p150Glued Is a Neuron-Specific Anti-Catastrophe Factor

(2013) Jacob E. Lazarus et al.   PLOS BIOLOGY

Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters

(2012) Liedewij Laan et al.   CELL

EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

(2012) Sebastian P. Maurer et al.   CELL

Estimating the Microtubule GTP Cap Size In Vivo

(2012) Dominique Seetapun et al.   CURRENT BIOLOGY

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins

(2012) Kai Jiang et al.   CURRENT BIOLOGY

Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends

(2012) Adam G. Hendricks et al.   CURRENT BIOLOGY

Amer2 Protein Interacts with EB1 Protein and Adenomatous Polyposis Coli (APC) and Controls Microtubule Stability and Cell Migration

(2012) Astrid S. Pfister et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1)

(2012) Praveen Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of dynamic microtubules withDrosophilaXMAP215, EB1, and Sentin

(2012) Wenjing Li et al.   JOURNAL OF CELL BIOLOGY

Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy

(2012) Hiroaki Yajima et al.   JOURNAL OF CELL BIOLOGY

Spectraplakins Promote Microtubule-Mediated Axonal Growth by Functioning As Structural Microtubule-Associated Proteins and EB1-Dependent +TIPs (Tip Interacting Proteins)

(2012) J. Alves-Silva et al.   JOURNAL OF NEUROSCIENCE

Fission yeast Alp14 is a dose-dependent plus end–tracking microtubule polymerase

(2012) Jawdat Al-Bassam et al.   MOLECULAR BIOLOGY OF THE CELL

The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning

(2012) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dissecting the Nanoscale Distributions and Functions of Microtubule-End-Binding Proteins EB1 and ch-TOG in Interphase HeLa Cells

(2012) Satoko Nakamura et al.   PLoS One

Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules

(2012) N. Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis

(2012) P. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A TOG:  -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

(2012) P. Ayaz et al.   SCIENCE

Move in for the kill: motile microtubule regulators

(2012) Xiaolei Su et al.   TRENDS IN CELL BIOLOGY

+TIPs: SxIPping along microtubule ends

(2012) Praveen Kumar et al.   TRENDS IN CELL BIOLOGY

Design, Overexpression, and Purification of Polymerization-Blocked Yeast αβ-Tubulin Mutants

(2011) Vinu Johnson et al.   BIOCHEMISTRY

Depolymerizing Kinesins Kip3 and MCAK Shape Cellular Microtubule Architecture by Differential Control of Catastrophe

(2011) Melissa K. Gardner et al.   CELL

Kif18A Uses a Microtubule Binding Site in the Tail for Plus-End Localization and Spindle Length Regulation

(2011) Lesley N. Weaver et al.   CURRENT BIOLOGY

A Complex of Kif18b and MCAK Promotes Microtubule Depolymerization and Is Negatively Regulated by Aurora Kinases

(2011) Marvin E. Tanenbaum et al.   CURRENT BIOLOGY

A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules

(2011) Makoto Iimori et al.   EXPERIMENTAL CELL RESEARCH

SLAIN2 links microtubule plus end–tracking proteins and controls microtubule growth in interphase

(2011) Babet van der Vaart et al.   JOURNAL OF CELL BIOLOGY

The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin

(2011) Agata Nawrotek et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice

(2011) Rubén M. Buey et al.   MOLECULAR BIOLOGY OF THE CELL

The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics

(2011) Joshua D. Currie et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms Underlying the Dual-Mode Regulation of Microtubule Dynamics by Kip3/Kinesin-8

(2011) Xiaolei Su et al.   MOLECULAR CELL

A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A

(2011) Jason Stumpff et al.   MOLECULAR CELL

K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly

(2011) Sylvain Meunier et al.   NATURE CELL BIOLOGY

MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

(2011) Catarina P. Samora et al.   NATURE CELL BIOLOGY

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

(2011) Dong Zhang et al.   NATURE CELL BIOLOGY

Microtubule nucleation by γ-tubulin complexes

(2011) Justin M. Kollman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region

(2011) P. O. Widlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP S microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs)

(2011) S. P. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP

(2011) Jawdat Al-Bassam et al.   TRENDS IN CELL BIOLOGY

A Minimal Midzone Protein Module Controls Formation and Length of Antiparallel Microtubule Overlaps

(2010) Peter Bieling et al.   CELL

Patronin Regulates the Microtubule Network by Protecting Microtubule Minus Ends

(2010) Sarah S. Goodwin et al.   CELL

Directed Microtubule Growth, +TIPs, and Kinesin-2 Are Required for Uniform Microtubule Polarity in Dendrites

(2010) Floyd J. Mattie et al.   CURRENT BIOLOGY

The Kinesin-8 Kif18A Dampens Microtubule Plus-End Dynamics

(2010) Yaqing Du et al.   CURRENT BIOLOGY

Mechanisms of force generation by end-on kinetochore-microtubule attachments

(2010) Ajit P Joglekar et al.   CURRENT OPINION IN CELL BIOLOGY

CLASP Promotes Microtubule Rescue by Recruiting Tubulin Dimers to the Microtubule

(2010) Jawdat Al-Bassam et al.   DEVELOPMENTAL CELL

The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex

(2010) Fabienne Lampert et al.   JOURNAL OF CELL BIOLOGY

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolution

(2010) Franck J. Fourniol et al.   JOURNAL OF CELL BIOLOGY

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane Invaginations Reveal Cortical Sites that Pull on Mitotic Spindles in One-Cell C. elegans Embryos

(2010) Stefanie Redemann et al.   PLoS One

The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

(2009) Andrew F. Powers et al.   CELL

Kinesin-8 Motors Act Cooperatively to Mediate Length-Dependent Microtubule Depolymerization

(2009) Vladimir Varga et al.   CELL

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

Molecular Insights into Mammalian End-binding Protein Heterodimerization

(2009) Christian O. De Groot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian end binding proteins control persistent microtubule growth

(2009) Yulia Komarova et al.   JOURNAL OF CELL BIOLOGY

Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p

(2009) Tomasz Zimniak et al.   JOURNAL OF CELL BIOLOGY

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

(2009) Jeremy R Cooper et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EB1 Recognizes the Nucleotide State of Tubulin in the Microtubule Lattice

(2009) Marija Zanic et al.   PLoS One

XMAP215 Is a Processive Microtubule Polymerase

(2008) Gary J. Brouhard et al.   CELL

Anchorage of Microtubule Minus Ends to Adherens Junctions Regulates Epithelial Cell-Cell Contacts

(2008) Wenxiang Meng et al.   CELL

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment

(2008) Jason Stumpff et al.   DEVELOPMENTAL CELL

Dynamic behavior of GFP–CLIP-170 reveals fast protein turnover on microtubule plus ends

(2008) Katharina A. Dragestein et al.   JOURNAL OF CELL BIOLOGY

Tracking the ends: a dynamic protein network controls the fate of microtubule tips

(2008) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues

(2008) A. Dimitrov et al.   SCIENCE

Capturing protein tails by CAP-Gly domains

(2008) Michel O. Steinmetz et al.   TRENDS IN BIOCHEMICAL SCIENCES