期刊
JOURNAL OF CELL SCIENCE
卷 132, 期 11, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.227850
关键词
CAMSAP; Centrosome; Dynein; Gamma-tubulin ring complex; Microtubule; Spindle pole
类别
资金
- European Research Council Synergy grant [609822]
- Swiss National Science Foundation [31003A_166608]
- European Research Council (ERC) [609822] Funding Source: European Research Council (ERC)
- Swiss National Science Foundation (SNF) [31003A_166608] Funding Source: Swiss National Science Foundation (SNF)
Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology. They are polarized polymeric tubes with a fast growing plus end and a slow growing minus end. In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge on the dynamics and organization of microtubule minus ends. Several factors, including the gamma-tubulin ring complex, CAMSAP/Patronin, ASPM/Asp, SPIRAL2 (in plants) and the KANSL complex recognize microtubule minus ends and regulate their nucleation, stability and interactions with partners, such as microtubule severing enzymes, microtubule depolymerases and protein scaffolds. Together with minus-end-directed motors, these microtubule minus-end targeting proteins (-TIPs) also control the formation of microtubule-organizing centers, such as centrosomes and spindle poles, and mediate microtubule attachment to cellular membrane structures, including the cell cortex, Golgi complex and the cell nucleus. Structural and functional studies are starting to reveal the molecular mechanisms by which dynamic -TIP networks control microtubule minus ends.
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