Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
出版年份 2017 全文链接
标题
Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
作者
关键词
-
出版物
Nature Communications
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-07-13
DOI
10.1038/s41467-017-00088-4
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
- (2016) Han-Jou Chen et al. BRAIN
- Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies
- (2016) Roberta Cascella et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells
- (2016) Pei-Yi Lin et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
- (2016) Wenzhang Wang et al. NATURE MEDICINE
- Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
- (2015) Adam K. Walker et al. ACTA NEUROPATHOLOGICA
- The Biology of Proteostasis in Aging and Disease
- (2015) Johnathan Labbadia et al. Annual Review of Biochemistry
- Chaperones in Neurodegeneration
- (2015) I. Lindberg et al. JOURNAL OF NEUROSCIENCE
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- An acetylation switch controls TDP-43 function and aggregation propensity
- (2015) Todd J. Cohen et al. Nature Communications
- Binding of TDP-43 to the 3′UTR of Its Cognate mRNA Enhances Its Solubility
- (2014) Yulong Sun et al. BIOCHEMISTRY
- Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
- (2014) Meredith E. Jackrel et al. CELL
- Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43
- (2014) Carola Stribl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids
- (2014) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
- (2014) Seiji Watanabe et al. Molecular Brain
- A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo
- (2013) Jieun R. C. Cha et al. CELL STRESS & CHAPERONES
- Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones
- (2013) Maria Udan-Johns et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models
- (2013) Jordi Magrané et al. HUMAN MOLECULAR GENETICS
- Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis
- (2013) Pei-Yi Lin et al. Molecular Neurodegeneration
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- Inhibition of TDP-43 Aggregation by Nucleic Acid Binding
- (2013) Yi-Chen Huang et al. PLoS One
- ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
- (2013) E. S. Arnold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration
- (2013) Naohide Kondo et al. Nature Communications
- Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion
- (2012) Johannes Brettschneider et al. ACTA NEUROPATHOLOGICA
- HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers
- (2012) Marc L. Mendillo et al. CELL
- Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection
- (2012) S. E. Avendano-Vazquez et al. GENES & DEVELOPMENT
- Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis
- (2012) S. Yamashita et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy
- (2011) Matthew B. Harms et al. ANNALS OF NEUROLOGY
- Understanding the role of TDP-43 and FUS/TLS in ALS and beyond
- (2011) Sandrine Da Cruz et al. CURRENT OPINION IN NEUROBIOLOGY
- Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
- (2011) Todd J Cohen et al. EMBO JOURNAL
- TDP-43: new aspects of autoregulation mechanisms in RNA binding proteins and their connection with human disease
- (2011) Emanuele Buratti et al. FEBS Journal
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Novel Types of Frontotemporal Lobar Degeneration: Beyond Tau and TDP-43
- (2011) Ian R. A. Mackenzie et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation
- (2011) Huei-Ying Li et al. PLoS One
- TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies
- (2011) Todd J. Cohen et al. TRENDS IN MOLECULAR MEDICINE
- Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT
- (2010) Naoki Hayashida et al. EMBO JOURNAL
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
- (2010) Chantelle F. Sephton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient
- (2010) A. Hernandez Lain et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
- (2010) Y.-F. Xu et al. JOURNAL OF NEUROSCIENCE
- Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis
- (2010) N. Keinan et al. MOLECULAR AND CELLULAR BIOLOGY
- Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis
- (2010) Shoichi Sasaki et al. NEUROSCIENCE LETTERS
- TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
- (2010) Aaron Voigt et al. PLoS One
- Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
- (2010) X. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease
- (2010) Daniel W. Neef et al. PLOS BIOLOGY
- Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
- (2009) Manuela Neumann et al. ACTA NEUROPATHOLOGICA
- Inflammatory myopathies: disease mechanisms
- (2009) Steven A Greenberg CURRENT OPINION IN NEUROLOGY
- Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
- (2009) G. S. Pesiridis et al. HUMAN MOLECULAR GENETICS
- TAR DNA-Binding Protein 43 Accumulation in Protein Aggregate Myopathies
- (2009) Montse Olivé et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis
- (2009) Mohammad Salajegheh et al. MUSCLE & NERVE
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions
- (2009) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- (2008) Lionel M. Igaz et al. AMERICAN JOURNAL OF PATHOLOGY
- TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia
- (2008) C C Weihl et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection
- (2008) Jingxian Yang et al. PLoS One
- Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease
- (2008) A. D. Steele et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
- (2008) B. S. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
- (2007) Paul S. Sharp et al. NEUROBIOLOGY OF DISEASE
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