Liquid-liquid phase separation drives skin barrier formation

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Transient Epidermal Barrier Deficiency and Lowered Allergic Threshold in Filaggrin-Hornerin (FlgHrnr -/- ) Double-Deficient Mice

(2019) Sebastian Rahrig et al.   ALLERGY

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

PhaSePro: the database of proteins driving liquid–liquid phase separation

(2019) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

Phase separation-deficient TDP43 remains functional in splicing

(2019) Hermann Broder Schmidt et al.   Nature Communications

Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins

(2018) Michael Dzuricky et al.   BIOCHEMISTRY

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

(2018) X.F. Colin C. Wong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Guilty by Association: Mapping Out the Molecular Sociology of Droplet Compartments

(2018) Simon Alberti   MOLECULAR CELL

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

(2018) Michael P. Hughes et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY

(2018) Daniel J. Scott et al.   Scientific Reports

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Kinase-controlled phase transition of membraneless organelles in mitosis

(2018) Arpan Kumar Rai et al.   NATURE

Controllable protein phase separation and modular recruitment to form responsive membraneless organelles

(2018) Benjamin S. Schuster et al.   Nature Communications

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons

(2017) Wenjing Wang et al.   NATURE BIOTECHNOLOGY

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Spatiotemporal coordination of stem cell commitment during epidermal homeostasis

(2016) P. Rompolas et al.   SCIENCE

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

(2015) Hao Jiang et al.   CELL

The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization

(2015) Shinji Noda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

(2015) Vinod Kumar et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin II, Stratifin, and HSP27

(2015) Christopher G. Bunick et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers

(2015) Felipe García Quiroz et al.   NATURE MATERIALS

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

Quantification of Protein Levels in Single Living Cells

(2015) Chiu-An Lo et al.   Cell Reports

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

(2014) Jennifer T Wang et al.   eLife

Predicting Transition Temperatures of Elastin-Like Polypeptide Fusion Proteins

(2013) Trine Christensen et al.   BIOMACROMOLECULES

Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects

(2013) David J. Margolis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments

(2012) Chang-Hun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Architecture Influences the Thermally Induced Aggregation Behavior of Elastin-like Polypeptides

(2011) Ali Ghoorchian et al.   BIOMACROMOLECULES

One Remarkable Molecule: Filaggrin

(2011) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Recursive Directional Ligation by Plasmid Reconstruction Allows Rapid and Seamless Cloning of Oligomeric Genes

(2010) Jonathan R. McDaniel et al.   BIOMACROMOLECULES

Quantitative Model of the Phase Behavior of Recombinant pH-Responsive Elastin-Like Polypeptides

(2010) J. Andrew MacKay et al.   BIOMACROMOLECULES

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

(2010) Chrystelle Bonnart et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

FLGmutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema

(2009) I. Nemoto-Hasebe et al.   BRITISH JOURNAL OF DERMATOLOGY

Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport

(2009) Danielle E. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Human Collagen XVIII Trimerization Domain: A Novel Collagen Trimerization Fold

(2009) Sergei P. Boudko et al.   JOURNAL OF MOLECULAR BIOLOGY

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

(2009) B. R. McNaughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE