Article
Cell Biology
Chen Qu, Wen Yang, Yating Kan, Hui Zuo, Mengqi Wu, Qing Zhang, Heng Wang, Dou Wang, Jiong Chen
Summary: Proper regulation of mitochondrial dynamics is critical for collective migration of Drosophila border cells during oogenesis. Misregulation of mitochondrial fission or fusion results in reduced ATP levels. RhoA/ROCK signaling may couple actomyosin dynamics with mitochondrial dynamics to achieve optimal actomyosin function during cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Vishakha Vishwakarma, Thao Phuong Le, Se Yeon Chung
Summary: During the invagination of Drosophila embryonic salivary gland, the GPCR Smog transduces the Fog signal to regulate Rho kinase accumulation and myosin activation, thereby controlling apical constriction. Smog also plays unexpected roles in maintaining epithelial integrity and organizing cortical actin.
Article
Developmental Biology
Donald F. Ready, Henry C. Chang
Summary: The study reveals a previously unknown phenomenon of Ca2+ waves propagating across the interommatidial cell (IOC) network in Drosophila eyes, promoting stress fiber contraction and shaping the retinal floor morphology. Genetic evidence shows that these waves are independent of phototransduction but require the inositol 1,4,5-triphosphate receptor (IP3R). Additionally, IOC waves interact with the extracellular matrix, affecting eye morphogenesis.
Article
Multidisciplinary Sciences
Jia-Yi Wei, Sao-Yu Chu, Yu-Chien Huang, Pei-Chi Chung, Hung-Hsiang Yu
Summary: Neurogenesis in the Drosophila central brain is influenced by a novel mutation called Nuwa, with significant impairment occurring during early larval stages. The mutation affects the generation of larval-born olfactory projection neurons but not embryonic-born neurons. Molecular characterization reveals that the Nuwa mutation is a loss-of-function mutation in the Drosophila septin interacting protein 1 (sip1). SIP1 expression is enriched in neuroblasts, and its knockdown leads to abnormal brain formation. The full-length SIP1 protein is necessary for rescuing the neurogenesis defect caused by the Nuwa mutation.
SCIENTIFIC REPORTS
(2022)
Article
Developmental Biology
Teresa Bonello, Mario Aguilar-Aragon, Alexander Tournier, Barry J. Thompson, Joseph P. Campanale
Summary: Adherens junctions play a crucial role in maintaining apical-basal polarization in epithelial cells by providing a diffusion barrier that restricts the spread of polarity determinants along the membrane for precise domain size control. Movement of adherens junctions in response to mechanical forces enables spontaneous adjustment of apical versus basolateral domain size as an emergent property of the polarising system.
CELLS & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Antonia Sugar, Maged Serag, Ulrich Buttner, Marwan Fahs, Satoshi Habuchi, Hussein Hoteit
Summary: Polymers have wide applications in the Oil & Gas Industry, but their interactions with porous rock often lead to changes in permeability. This study utilizes fluorescent polymers and single-molecule imaging to assess the dynamic interaction and transport behavior of polymer molecules. Pore-scale simulations are performed to replicate the experimental observations.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Xiao Xu, Huanping An, Cheng Wu, Rong Sang, Litao Wu, Yuhan Lou, Xiaohang Yang, Yongmei Xi
Summary: Environmental stress can lead to mutation or genomic instability in stem cells, which can cause tumorigenesis. This study used the Drosophila larval brain as a model and found that X-ray irradiation leads to the accumulation of nuclear Prospero (Pros), resulting in premature differentiation of neural stem cells. Through RNAi screenings, it was determined that the Mre11-Rad50-Nbs1 complex and the homologous recombination repair pathway play a dominant role in maintaining neural stem cells under irradiation stress. The accumulation of nuclear Pros under irradiation stress leads to neural stem cell fate termination, rather than mutant cell proliferation. This study reveals a new mechanism for the homologous recombination repair pathway in maintaining neural stem cell fate under irradiation stress.
LIFE SCIENCE ALLIANCE
(2023)
Article
Neurosciences
U. Nguyen, B. Tinsley, Y. Sen, J. Stein, Y. Palacios, A. Ceballos, C. Welch, K. Nzenkue, A. Penn, L. Murphy, K. Leodones, J. Casiquin, I. Ivory, K. Ghenta, K. Danziger, E. Widman, J. Newman, M. Triplehorn, Z. Hindi, K. Mulligan
Summary: Research investigated the neurodevelopmental impacts of BPA on fruit flies across different genetic strains, showing that BPA can have varying effects depending on genetic background, indicating a potential gene-environment interaction.
Article
Biochemistry & Molecular Biology
Sophie Hecht, Gantas Perez-Mockus, Dominik Schienstock, Carles Recasens-Alvarez, Sara Merino-Aceituno, Matt Smith, Guillaume Salbreux, Pierre Degond, Jean-Paul Vincent
Summary: This study explores the mechanisms behind cell growth termination and suggests that mechanical feedback may play a role via adherens junctions. It also proposes that nuclei may play a role in sensing mechanical stress and gravity. By developing a model, the research provides important insights into nuclear migration and mechanical effects during growth.
Article
Biochemical Research Methods
Antonia Sugar, Maged Serag, Ulrich Buttner, Satoshi Habuchi, Hussein Hoteit
Summary: Understanding the dynamic behavior of polymeric fluids in porous media is necessary for various geoscience applications, such as enhanced oil recovery and polymer-enhanced soil washing for soil contamination clean-up. By integrating microfluidics with single-molecule imaging, this study directly visualizes and characterizes the dynamic behavior of polymer molecules in a representative porous medium, revealing their adsorption, entrapment and hydrodynamic retention contribute to their overall retention in porous media. These findings have significant implications for better capturing the behavior of complex fluids in confined environments and can lead to improved models for various applications in geoscience, materials science, and rheology.
Article
Biochemical Research Methods
Antonia Sugar, Maged Serag, Ulrich Buttner, Satoshi Habuchi, Hussein Hoteit
Summary: Understanding the dynamic behavior of polymeric fluids in porous media is crucial for various geoscience applications, such as enhanced oil recovery and soil decontamination. By integrating microfluidics with single-molecule imaging, we directly visualize and characterize the dynamic behavior of polymer molecules in a representative porous medium. Our study reveals the contributions of polymer adsorption, entrapment, and hydrodynamic retention to their overall retention in porous media.
Article
Multidisciplinary Sciences
Yunpo Zhao, Mohammed A. Khallaf, Emilia Johansson, Najat Dzaki, Shreelatha Bhat, Johannes Alfredsson, Jianli Duan, Bill S. Hansson, Markus Knaden, Mattias Alenius
Summary: Research shows that sugar intake in Drosophila induces the gut to secrete Hedgehog (Hh) protein, suppressing sweet sensation and perception. The gut-derived Hh signal also inhibits bitter taste and odor responses, affecting overall food perception and preference. Early sugar intake levels affect adult gut Hh expression and sweet taste perception.
NATURE COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
M. Pecovnik, T. Schwarz-Selinger, S. Markelj
Summary: In this study, bulk tungsten samples were irradiated sequentially with 20 MeV tungsten ions and exposed to deuterium plasma to simulate displacement damage in a future fusion device. The presence of hydrogen isotopes during damage creation was found to influence the final defect density. Experimental and modeling results showed that deuterium concentration increased with each cycle of irradiation and exposure, reaching a maximum after three cycles. The model predicts a stationary state with a maximum trapped deuterium concentration after about five cycles.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Biochemical Research Methods
Alexander Nestor-Bergmann, Guy B. Blanchard, Nathan Hervieux, Alexander G. Fletcher, Jocelyn Etienne, Benedicte Sanson
Summary: Cell intercalation is a crucial cell behavior involved in morphogenesis and wound healing, which can cause significant tissue deformations. This study introduces a new model to understand the mechanisms of cell intercalation, specifically focusing on the interaction between cell cortices and adhesion molecules.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Developmental Biology
Juan Lu, Wei Dong, Yan Tao, Yang Hong
Summary: Dig, an essential polarity protein and tumor suppressor, contains a positively charged polybasic domain that binds to phosphoinositides on the plasma membrane, contributing significantly to its localization and function in polarity and tumorigenesis. This electrostatic targeting of Dig is controlled by potential phosphorylation-dependent regulation and interactions with other polarity proteins, highlighting the importance of electrostatic PM targeting in regulating cell polarity.
Article
Developmental Biology
Anne Ramat, Agnes Audibert, Sophie Louvet-Vallee, Francoise Simon, Pierre Fichelson, Michel Gho
Article
Cell Biology
Alexandre D. Baffet, Beatrice Benoit, Jens Januschke, Jennifer Audo, Vanessa Gourhand, Siegfried Roth, Antoine Guichet
MOLECULAR BIOLOGY OF THE CELL
(2012)
Article
Cell Biology
J. Januschke, J. Reina, S. Llamazares, T. Bertran, F. Rossi, J. Roig, C. Gonzalez
NATURE CELL BIOLOGY
(2013)
Review
Cell Biology
Jens Januschke, Inke Naethke
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2014)
Article
Developmental Biology
Matthew Hannaford, Nicolas Loyer, Francesca Tonelli, Martin Zoltner, Jens Januschke
Article
Genetics & Heredity
Francoise Simon, Anne Ramat, Sophie Louvet-Vallee, Jerome Lacoste, Angelique Burg, Agnes Audibert, Michel Gho
Article
Cell Biology
Anne Ramat, Maria-Rosa Garcia-Silva, Camille Jahan, Rima Nait-Saidi, Jeremy Dufourt, Celine Garret, Aymeric Chartier, Julie Cremaschi, Vipul Patel, Mathilde Decourcelle, Amandine Bastide, Francois Juge, Martine Simonelig
Review
Genetics & Heredity
Anne Ramat, Martine Simonelig
Summary: piRNAs and PIWI proteins play crucial roles in biological and developmental processes by regulating cellular mRNAs. These functions are ancestral and recent research has expanded our understanding of the mechanisms of action and the conservation of PIWI proteins in distant species.
TRENDS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
John M. Ryniawec, Matthew R. Hannaford, Melanie E. Zibrat, Carey J. Fagerstrom, Brian J. Galletta, Sophia E. Aguirre, Bethany A. Guice, Spencer M. Dean, Nasser M. Rusan, Gregory C. Rogers
Summary: Proper centrosome assembly and function rely on accurate assembly of centrioles and synchronized growth of microtubules. This study identifies Cep104 as a novel protein involved in centriole growth and elongation. Furthermore, Cep104 and Cep97 cooperate in spermiogenesis to coordinate individualization by regulating centriole assembly and alignment.
Article
Biochemistry & Molecular Biology
Anne Ramat, Matthew Hannaford, Jens Januschke
