期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 44, 期 7, 页码 565-574出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.03.001
关键词
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资金
- European Research Council (Project 4D Genome) [609989]
- Ministerio de Economia y Competitividad [G62426937]
- Generalitat de Catalunya (project Agencia de Gestio d'Ajuts Universitaris i de Recerca) [SGR 575]
Misregulation of the processes controlling eukaryotic gene expression can result in disease. Gene expression is influenced by the surrounding chromatin; hence the nuclear environment is also of vital importance. Recently, understanding of chromatin hierarchical folding has increased together with the discovery of membrane-less organelles which are distinct, dynamic liquid droplets that merge and expand within the nucleus. These 'sieve'-like regions may compartmentalize and separate functionally distinct regions of chromatin. This article aims to discuss recent studies on nuclear phase within the context of poly (ADP-ribose), ATP, and Mg2+ levels, and we propose a combinatorial complex role for these molecules in phase separation and genome regulation. We also discuss the implications of this process for gene regulation and discuss possible strategies to test this.
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