Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
出版年份 2020 全文链接
标题
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
作者
关键词
-
出版物
PHARMACOLOGICAL REVIEWS
Volume 72, Issue 2, Pages 486-526
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2020-03-21
DOI
10.1124/pr.119.018440
参考文献
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- Blockage of STAT3 Signaling Pathway with a Decoy Oligodeoxynucleotide Inhibits Growth of Human Ovarian Cancer Cells
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- OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells
- (2013) Mi-Jung Kim et al. CANCER LETTERS
- A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation
- (2013) X. Zhang et al. CANCER RESEARCH
- Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
- (2013) Naoko Ohtani et al. CANCER SCIENCE
- Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass
- (2013) Liping Zhang et al. Cell Metabolism
- Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
- (2013) L. Grant et al. DIABETES
- STAT3-mediated activation of microRNA cluster 17 92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma
- (2013) E. Spaccarotella et al. HAEMATOLOGICA
- Remission of food allergy by the Janus kinase inhibitor ruxolitinib in mice
- (2013) Kouya Yamaki et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo
- (2013) XIAOLEI ZHANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
- (2013) Andrea M. Siegel et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
- (2013) Shu-Chen Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Control of inflammation by integration of environmental cues by regulatory T cells
- (2013) Ashutosh Chaudhry et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-21 and CD40L Synergistically Promote Plasma Cell Differentiation through Upregulation of Blimp-1 in Human B Cells
- (2013) B. B. Ding et al. JOURNAL OF IMMUNOLOGY
- Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock
- (2013) Stephen Thacker et al. JOURNAL OF INFECTION
- STAT signaling in mammary gland differentiation, cell survival and tumorigenesis
- (2013) S. Haricharan et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
- (2013) Nadia J Kershaw et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- JAKs and STATs in Immunity, Immunodeficiency, and Cancer
- (2013) John J. O'Shea et al. NEW ENGLAND JOURNAL OF MEDICINE
- Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma
- (2013) Yunbao Pan et al. PLoS One
- Imatinib Reverses Doxorubicin Resistance by Affecting Activation of STAT3-Dependent NF-κB and HSP27/p38/AKT Pathways and by Inhibiting ABCB1
- (2013) Jonathan T. Sims et al. PLoS One
- Dimethylfumarate Suppresses Adipogenic Differentiation in 3T3-L1 Preadipocytes through Inhibition of STAT3 Activity
- (2013) Hyeon-Ji Kang et al. PLoS One
- Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b
- (2013) G. Curtale et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance
- (2013) S. J. Priceman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of autophagy by stress-responsive transcription factors
- (2013) Federico Pietrocola et al. SEMINARS IN CANCER BIOLOGY
- Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells
- (2013) W-T Tai et al. Cell Death & Disease
- A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases
- (2013) F Hayakawa et al. Blood Cancer Journal
- Modulation of the Unfolded Protein Response During Hepatocyte and Cardiomyocyte Apoptosis In Trauma/Hemorrhagic Shock
- (2013) Stephen A. Thacker et al. Scientific Reports
- Anti-inflammatory therapy
- (2013) Aminah Jatoi Current Opinion in Supportive and Palliative Care
- Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity
- (2012) Yuka Kanno et al. Annual Review of Immunology
- Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice
- (2012) C. Walz et al. BLOOD
- Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
- (2012) C. Mantel et al. BLOOD
- The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
- (2012) H. S. Li et al. BLOOD
- Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages
- (2012) A. P. Hutchins et al. BLOOD
- DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors
- (2012) Un Jung Yun et al. CANCER LETTERS
- MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts
- (2012) Hao Wu et al. CELLULAR SIGNALLING
- Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Collagen-Induced Platelet Aggregation Independently of Its Transcription Factor Activity
- (2012) Zhou Zhou et al. CIRCULATION
- A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas
- (2012) D. S. Hong et al. CLINICAL CANCER RESEARCH
- Asthma phenotypes and endotypes
- (2012) Ting-Yu Lin et al. CURRENT OPINION IN PULMONARY MEDICINE
- Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes
- (2012) F. Mashili et al. DIABETES
- Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
- (2012) Sebastian Beck Jorgensen et al. DIABETES
- Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis
- (2012) Robert J. J. O'Donoghue et al. EMBO Molecular Medicine
- Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45
- (2012) Ryohei Wakahara et al. GENES TO CELLS
- Biology and significance of the JAK/STAT signalling pathways
- (2012) Hiu Kiu et al. GROWTH FACTORS
- Janus Kinase Deregulation in Leukemia and Lymphoma
- (2012) Edwin Chen et al. IMMUNITY
- STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease
- (2012) Arian Laurence et al. IMMUNITY
- Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
- (2012) Jeffrey J. Babon et al. IMMUNITY
- Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression
- (2012) Fanny Chalmin et al. IMMUNITY
- Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes
- (2012) Mazen Kurdi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis
- (2012) Ying Dunkel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interleukin-10 Inhibits Lipopolysaccharide-induced Tumor Necrosis Factor-α Translation through a SHIP1-dependent Pathway
- (2012) Catherine S. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA
- (2012) Olga A. Timofeeva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
- (2012) Prasad Tammineni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study
- (2012) K.R. Herrlinger et al. Journal of Crohns & Colitis
- Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells
- (2012) M. Tkach et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: IL-10-Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production
- (2012) A. Gaba et al. JOURNAL OF IMMUNOLOGY
- G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
- (2012) Hoainam T. Nguyen-Jackson et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Clues to apoptosis pathway involvement in hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome and intrauterine growth restriction (IUGR)
- (2012) Monia Cecati et al. Journal of Maternal-Fetal & Neonatal Medicine
- Signal Transducer and Activator of Transcription 2 (STAT2) Metabolism Coupling Postmitotic Outgrowth to Visual and Sound Perception Network in Human Left Cerebrum by Biocomputation
- (2012) Lin Wang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Quantitative analysis of cellular senescence phenotypes using an imaging cytometer
- (2012) Miyako Udono et al. METHODS
- Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity
- (2012) Shensi Shen et al. MOLECULAR CELL
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma
- (2012) Tiffany A. Doucette et al. NEURO-ONCOLOGY
- A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis
- (2012) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis
- (2012) Claire Harrison et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis
- (2012) William J. Sandborn et al. NEW ENGLAND JOURNAL OF MEDICINE
- JAK/STAT signaling in hematological malignancies
- (2012) W Vainchenker et al. ONCOGENE
- Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive
- (2012) Carlos Zgheib et al. PLoS One
- Regulation of Insulin and Leptin Signaling by Muscle Suppressor of Cytokine Signaling 3 (SOCS3)
- (2012) Zhenggang Yang et al. PLoS One
- Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
- (2012) H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Sin3a repressor complex is a master regulator of STAT transcriptional activity
- (2012) Laura Icardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- JNK-Dependent Stat3 Phosphorylation Contributes to Akt Activation in Response to Arsenic Exposure
- (2012) J. Liu et al. TOXICOLOGICAL SCIENCES
- An update on the hyper-IgE syndromes
- (2012) Patrick FK Yong et al. ARTHRITIS RESEARCH & THERAPY
- First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
- (2012) Malabika Sen et al. Cancer Discovery
- Mouse Skeletal Muscle Fiber-Type-Specific Macroautophagy and Muscle Wasting Are Regulated by a Fyn/STAT3/Vps34 Signaling Pathway
- (2012) Eijiro Yamada et al. Cell Reports
- Molecular Mechanisms of Alcoholic Liver Disease: Innate Immunity and Cytokines
- (2011) Andrew M. Miller et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons
- (2011) Guillaume de Lartigue et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling
- (2011) Anantha S. Metlakunta et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells
- (2011) Shuling Huang et al. CANCER LETTERS
- H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload
- (2011) Hongyu Qiu et al. CIRCULATION
- Certolizumab Pegol for Active Crohn's Disease: A Placebo-Controlled, Randomized Trial
- (2011) William J. Sandborn et al. Clinical Gastroenterology and Hepatology
- The Use of Structural Biology in Janus Kinase Targeted Drug Discovery
- (2011) Nilda L. Alicea-Velazquez et al. CURRENT DRUG TARGETS
- Recent advances in the IL-17 cytokine family
- (2011) Sarah L Gaffen CURRENT OPINION IN IMMUNOLOGY
- New IBD genetics: common pathways with other diseases
- (2011) C. W. Lees et al. GUT
- Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways
- (2011) Ayumi Takakura et al. HUMAN MOLECULAR GENETICS
- Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation
- (2011) Ashutosh Chaudhry et al. IMMUNITY
- An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
- (2011) Weiguo Cui et al. IMMUNITY
- A Distal Enhancer inIl12bIs the Target of Transcriptional Repression by the STAT3 Pathway and Requires the Basic Leucine Zipper (B-ZIP) Protein NFIL3
- (2011) Amber M. Smith et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition
- (2011) Hua Xiong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species
- (2011) Karol Szczepanek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3
- (2011) M. Vogt et al. JOURNAL OF CELL SCIENCE
- Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study
- (2011) Ayalew Tefferi et al. JOURNAL OF CLINICAL ONCOLOGY
- Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10
- (2011) Hongwei Wang et al. JOURNAL OF IMMUNOLOGY
- A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning
- (2011) Roberto Bolli et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3
- (2011) Karol Szczepanek et al. MITOCHONDRION
- Immunity as a link between obesity and insulin resistance
- (2011) Nishan S. Kalupahana et al. MOLECULAR ASPECTS OF MEDICINE
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
- (2011) Carl A Anderson et al. NATURE GENETICS
- Forming functional fat: a growing understanding of adipocyte differentiation
- (2011) Ana G. Cristancho et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse
- (2011) James P. White et al. PLoS One
- Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production
- (2011) Hua Wang et al. Cell and Bioscience
- Impact of cellular senescence signature on ageing research
- (2010) Ewa Sikora et al. AGEING RESEARCH REVIEWS
- Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
- (2010) Kerstin Boengler et al. BASIC RESEARCH IN CARDIOLOGY
- STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
- (2010) H. Nguyen-Jackson et al. BLOOD
- STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
- (2010) I. Hazan-Halevy et al. BLOOD
- STAT3 controls myeloid progenitor growth during emergency granulopoiesis
- (2010) H. Zhang et al. BLOOD
- Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
- (2010) K. T. Liby et al. Cancer Prevention Research
- Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3
- (2010) L. Li et al. CANCER RESEARCH
- Bcl-XL and STAT3 mediate malignant actions of γ-irradiation in lung cancer cells
- (2010) Jin-Nyoung Ho et al. CANCER SCIENCE
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
- (2010) Eek Joong Park et al. CELL
- DNA Damage-Mediated Induction of a Chemoresistant Niche
- (2010) Luke A. Gilbert et al. CELL
- Lysine methylation of promoter-bound transcription factors and relevance to cancer
- (2010) George R Stark et al. CELL RESEARCH
- Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction
- (2010) Denise Hilfiker-Kleiner et al. CIRCULATION
- Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation
- (2010) Hiroaki Iwasaki et al. CIRCULATION RESEARCH
- Therapeutic Potential of Janus-activated Kinase-2 Inhibitors for the Management of Myelofibrosis
- (2010) S. Verstovsek CLINICAL CANCER RESEARCH
- T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis
- (2010) Atsushi Fukushima et al. DIABETES
- PD-L1 expression on tolerogenic APCs is controlled by STAT-3
- (2010) Sabine J. Wölfle et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage
- (2010) Toshinori Bito et al. EXPERIMENTAL DERMATOLOGY
- Unphosphorylated STAT and heterochromatin protect genome stability
- (2010) Shian-Jang Yan et al. FASEB JOURNAL
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
- (2010) Sung Hwan Ki et al. HEPATOLOGY
- Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis
- (2010) Lydia Durant et al. IMMUNITY
- Mechanisms regulating dendritic cell specification and development
- (2010) Stephanie S. Watowich et al. IMMUNOLOGICAL REVIEWS
- STAT3 modulates the DNA damage response pathway
- (2010) Seán P. Barry et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy
- (2010) Dominic C. H. Ng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition
- (2010) Sandy Courapied et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulatingC/EBPβtranscription
- (2010) Kunming Zhang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Evaluation of toxicity and Stat3 activation induced by hydrogen peroxide exposure to the skin in healthy individuals
- (2010) Toshinori Bito et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Dendritic Cell (DC)-Specific Targeting Reveals Stat3 as a Negative Regulator of DC Function
- (2010) Jessica A. Melillo et al. JOURNAL OF IMMUNOLOGY
- The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins
- (2010) HyeonJoo Cheon et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
- (2010) Maoyin Pang et al. KIDNEY INTERNATIONAL
- Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion
- (2010) U. K. Mukhopadhyay et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy and the Integrated Stress Response
- (2010) Guido Kroemer et al. MOLECULAR CELL
- Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro
- (2010) Theodore A. Sarafian et al. PLoS One
- Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
- (2010) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer
- (2009) Bharat B. Aggarwal et al. Annals of the New York Academy of Sciences
- Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor γ (PPARγ)
- (2009) Dongmei Wang et al. BIOLOGY OF THE CELL
- Dendritic cell homeostasis
- (2009) M. Merad et al. BLOOD
- Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
- (2009) Heehyoung Lee et al. CANCER CELL
- Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy
- (2009) Hong Yue et al. CARDIOVASCULAR RESEARCH
- Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway
- (2009) Matthias Brock et al. CIRCULATION RESEARCH
- Prevention of Trauma/Hemorrhagic Shock-Induced Lung Apoptosis by IL-6-Mediated Activation of Stat3
- (2009) Ana Moran et al. CTS-Clinical and Translational Science
- Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice
- (2009) Daniela C. Kroy et al. HEPATOLOGY
- Janus kinases in immune cell signaling
- (2009) Kamran Ghoreschi et al. IMMUNOLOGICAL REVIEWS
- Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients
- (2009) Roni Mintz et al. IMMUNOLOGY LETTERS
- Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
- (2009) Albert Lin et al. IMMUNOLOGY LETTERS
- TH17-associated cytokines (IL-17A and IL-17F) in severe asthma
- (2009) Wisam Al-Ramli et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation
- (2009) Jeong-Ho Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
- (2009) Jia-Lin Lee et al. JOURNAL OF CELL BIOLOGY
- Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias
- (2009) Mustafa Benekli et al. JOURNAL OF CLINICAL ONCOLOGY
- STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
- (2009) Geethanjali Pickert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10
- (2009) B. Schaljo et al. JOURNAL OF IMMUNOLOGY
- Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis
- (2009) Yu-cheng Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- STAT3 Targets the Regulatory Regions of Gluconeogenic Genesin Vivo
- (2009) Preeti Ramadoss et al. MOLECULAR ENDOCRINOLOGY
- STAT3 inhibition of gluconeogenesis is downregulated by SirT1
- (2009) Yongzhan Nie et al. NATURE CELL BIOLOGY
- Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation
- (2009) S Hegde et al. ONCOGENE
- Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
- (2009) Xuejun Xu et al. PLoS One
- Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
- (2009) D. J. Gough et al. SCIENCE
- Function of Mitochondrial Stat3 in Cellular Respiration
- (2009) J. Wegrzyn et al. SCIENCE
- CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner
- (2009) A. Chaudhry et al. SCIENCE
- STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells
- (2009) Maureen M. Sherry et al. STEM CELLS
- Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
- (2008) Xiaoxia Sun et al. CANCER LETTERS
- The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition
- (2008) A. Vigneron et al. CANCER RESEARCH
- Triterpenoid CDDO-Methyl Ester Inhibits the Janus-Activated Kinase-1 (JAK1)->Signal Transducer and Activator of Transcription-3 (STAT3) Pathway by Direct Inhibition of JAK1 and STAT3
- (2008) R. Ahmad et al. CANCER RESEARCH
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Prevention and Treatment of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
- (2008) K. Liby et al. CLINICAL CANCER RESEARCH
- Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease
- (2008) Silvia Sookoian et al. CYTOKINE
- S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling
- (2008) Yi Xie et al. ENDOCRINOLOGY
- Cell Type–Dependent Pro- and Anti-Inflammatory Role of Signal Transducer and Activator of Transcription 3 in Alcoholic Liver Injury
- (2008) Norio Horiguchi et al. GASTROENTEROLOGY
- A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease
- (2008) William J. Sandborn et al. GASTROENTEROLOGY
- Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
- (2008) N. de la Iglesia et al. GENES & DEVELOPMENT
- The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8
- (2008) Eiji Esashi et al. IMMUNITY
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
- (2008) Xuexian O. Yang et al. IMMUNITY
- Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs
- (2008) Xuexian O. Yang et al. IMMUNITY
- The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain
- (2008) Tieying Hou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3
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- Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
- (2008) Pingyan Cheng et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interleukin 21: a cytokine/cytokine receptor system that has come of age
- (2008) Warren J. Leonard et al. JOURNAL OF LEUKOCYTE BIOLOGY
- STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5′ and 3′ ends
- (2008) H. Dan Lewis et al. MOLECULAR CANCER THERAPEUTICS
- Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
- (2008) Joshua D. Milner et al. NATURE
- Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
- (2008) Song Shi et al. NATURE CELL BIOLOGY
- Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
- (2008) S. Ray et al. NUCLEIC ACIDS RESEARCH
- Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
- (2008) M. Marzec et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
- (2008) Y TANAKA et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Adipose-Specific Disruption of Signal Transducer and Activator of Transcription 3 Increases Body Weight and Adiposity
- (2007) Erin R. Cernkovich et al. ENDOCRINOLOGY
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