Targeting JAK kinase in solid tumors: emerging opportunities and challenges

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

(2015) Beatrice Grabner et al.   Nature Communications

CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells

(2015) Shi-Jie Wang et al.   Oncotarget

A1.72 Baricitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and efficacy in an open-label, long-term extension study1

(2014) Peter Taylor et al.   ANNALS OF THE RHEUMATIC DISEASES

Selective inhibitors of the Janus kinase Jak3—Are they effective?

(2014) Gebhard Thoma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer

(2014) E Letellier et al.   BRITISH JOURNAL OF CANCER

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Selective JAK inhibitors in development for rheumatoid arthritis

(2014) Peter Norman   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice

(2014) E. Stuart et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Endogenous IL-22 Plays a Dual Role in Arthritis: Regulation of Established Arthritis via IFN-γ Responses

(2014) Shivali Justa et al.   PLoS One

Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

(2014) Louise M. Judd et al.   PLoS One

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt- -catenin-mediated intestinal tumor growth and regeneration

(2014) T. J. Phesse et al.   Science Signaling

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

The IL-6 feed-forward loop: A driver of tumorigenesis

(2014) Qing Chang et al.   SEMINARS IN IMMUNOLOGY

Significance of −1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression

(2014) Lyuba D. Miteva et al.   TUMOR BIOLOGY

ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer

(2014) Sandra Van Schaeybroeck et al.   Cell Reports

Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma

(2014) Karine Poussin et al.   OncoImmunology

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

(2013) Tracy L. Putoczki et al.   CANCER CELL

SHP2 Is Overexpressed and Inhibits pSTAT1-Mediated APM Component Expression, T-cell Attracting Chemokine Secretion, and CTL Recognition in Head and Neck Cancer Cells

(2013) M. S. Leibowitz et al.   CLINICAL CANCER RESEARCH

JAK1/2 and Pan-Deacetylase Inhibitor Combination Therapy Yields Improved Efficacy in Preclinical Mouse Models of JAK2V617F-Driven Disease

(2013) E. Evrot et al.   CLINICAL CANCER RESEARCH

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma

(2013) Li Zhang et al.   HEPATOLOGY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

Modulation of antitumour immune responses by intratumoural Stat1 expression

(2013) Nicole L Messina et al.   IMMUNOLOGY AND CELL BIOLOGY

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

(2013) Meng Ling Choong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells

(2013) Barbara Onnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis

(2013) A Pardanani et al.   LEUKEMIA

Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis

(2013) Xinyu Qiu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dual PI3K/AKT/mTOR Inhibitor BEZ235 Synergistically Enhances the Activity of JAK2 Inhibitor against Cultured and Primary Human Myeloproliferative Neoplasm Cells

(2013) W. Fiskus et al.   MOLECULAR CANCER THERAPEUTICS

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AZD1480: A Phase I Study of a Novel JAK2 Inhibitor in Solid Tumors

(2013) E. R. Plimack et al.   ONCOLOGIST

P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387

(2013) S. Durmus et al.   PHARMACOLOGICAL RESEARCH

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

(2013) Daniel J. Gough et al.   PLoS One

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

(2012) J. Emmerich et al.   CANCER RESEARCH

IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer

(2012) Yi Li et al.   CARCINOGENESIS

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut

(2012) J. B. Cordero et al.   DEVELOPMENT

IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin

(2012) Heather M. McGee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased Serum Interleukin 22 in Patients with Rheumatoid Arthritis and Correlation with Disease Activity

(2012) LAURINDO FERREIRA da ROCHA et al.   JOURNAL OF RHEUMATOLOGY

Therapeutic Efficacy of CEP-33779, a Novel Selective JAK2 Inhibitor, in a Mouse Model of Colitis-Induced Colorectal Cancer

(2012) M. M. Seavey et al.   MOLECULAR CANCER THERAPEUTICS

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

(2012) Priya Koppikar et al.   NATURE

Lymphotoxin regulates commensal responses to enable diet-induced obesity

(2012) Vaibhav Upadhyay et al.   NATURE IMMUNOLOGY

Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis

(2012) Ronald F. van Vollenhoven et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner

(2012) Christine W. Duarte et al.   PLoS One

Random Mutagenesis Reveals Residues of JAK2 Critical in Evading Inhibition by a Tyrosine Kinase Inhibitor

(2012) Michael R. Marit et al.   PLoS One

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Prolactin Promotes Hepatocellular Carcinoma through Janus Kinase 2

(2012) Yao-Tsung Yeh et al.   WORLD JOURNAL OF SURGERY

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML

(2012) V Novotny-Diermayr et al.   Blood Cancer Journal

Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent

(2012) Rita Andraos et al.   Cancer Discovery

SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation

(2011) Carina Lindemann et al.   ACTA NEUROPATHOLOGICA

Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis

(2011) J. Leipe et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Jak1 Has a Dominant Role over Jak3 in Signal Transduction through γc-Containing Cytokine Receptors

(2011) Claude Haan et al.   CHEMISTRY & BIOLOGY

Heat Shock Protein 90 Inhibitor Is Synergistic with JAK2 Inhibitor and Overcomes Resistance to JAK2-TKI in Human Myeloproliferative Neoplasm Cells

(2011) W. Fiskus et al.   CLINICAL CANCER RESEARCH

EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

(2011) B. Biteau et al.   DEVELOPMENT

p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

(2011) Doris Schneller et al.   HEPATOLOGY

IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3

(2011) Sadahiro Kamiya et al.   IMMUNOLOGY LETTERS

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer

(2011) Christina Greenwood et al.   Journal of Proteomics

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

(2011) K A Monaghan et al.   LEUKEMIA

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

(2011) L Y W Bourguignon et al.   ONCOGENE

PHOSPHO-STAT5 Expression is Associated with Poor Prognosis of Human Colonic Adenocarcinoma

(2011) Yin-Ling Mao et al.   PATHOLOGY & ONCOLOGY RESEARCH

The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma

(2011) E Derenzini et al.   Blood Cancer Journal

Aberrant promoter methylation and loss of Suppressor of Cytokine Signalling-1 gene expression in the development of uterine cervical carcinogenesis

(2011) R. C. Sobti et al.   CELLULAR ONCOLOGY

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells

(2010) Fu-Yu Chueh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells

(2010) B. Will et al.   BLOOD

Gene Signature in Melanoma Associated With Clinical Activity

(2010) Thomas F. Gajewski et al.   CANCER JOURNAL

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

(2010) P. Karpowicz et al.   DEVELOPMENT

PD-L1 expression on tolerogenic APCs is controlled by STAT-3

(2010) Sabine J. Wölfle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer

(2010) J. A. D. Simpson et al.   GUT

IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines

(2010) Wiltrud Lederle et al.   INTERNATIONAL JOURNAL OF CANCER

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

(2010) Francesco Pierconti et al.   PROSTATE

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

(2009) C. Pecquet et al.   BLOOD

Impaired development of human Th1 cells in patients with deficient expression of STAT4

(2009) H.-C. Chang et al.   BLOOD

Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells

(2009) Y. Wang et al.   BLOOD

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate

(2009) Andre Luiz Mencalha et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

Drosophila Intestinal Response to Bacterial Infection: Activation of Host Defense and Stem Cell Proliferation

(2009) Nicolas Buchon et al.   Cell Host & Microbe

JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage

(2009) Katherine Beebe et al.   DEVELOPMENTAL BIOLOGY

Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice

(2009) Monica Musteanu et al.   GASTROENTEROLOGY

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Disruption of the growth hormone-Signal transducer and activator of transcription 5-Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

(2009) Leander Blaas et al.   HEPATOLOGY

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

(2009) Atsushi Hosui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

(2009) Lin Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ER Re-expression and Re-sensitization to Endocrine Therapies in ER-negative Breast Cancers

(2009) Joeli A. Brinkman et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells

(2009) Hua Xiong et al.   LABORATORY INVESTIGATION

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

(2009) M Walter et al.   ONCOGENE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

(2008) M Colomiere et al.   BRITISH JOURNAL OF CANCER

Practical guidelines for the management of interferon-α-2b side effects in patients receiving adjuvant treatment for melanoma

(2008) Axel Hauschild et al.   CANCER

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

(2008) Sergei Grivennikov et al.   CANCER CELL

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Transcription Factor Signal Transducer and Activator of Transcription 5 Promotes Growth of Human Prostate Cancer Cells In vivo

(2008) A. Dagvadorj et al.   CLINICAL CANCER RESEARCH

Signal transducer and activator of transcription 5A/B in prostate and breast cancers

(2008) S.-H. Tan et al.   ENDOCRINE-RELATED CANCER

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme

(2008) Maurizio Martini et al.   INTERNATIONAL JOURNAL OF CANCER

Leptin signaling in breast cancer: An overview

(2008) Donatella Cirillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1  RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

(2008) G. Niu et al.   MOLECULAR CANCER RESEARCH

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling

(2008) Suhu Liu et al.   Pigment Cell & Melanoma Research

Interleukin-6 and cachexia in ApcMin/+ mice

(2007) Kristen A. Baltgalvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY