期刊
FEBS JOURNAL
卷 283, 期 16, 页码 3002-3015出版社
WILEY
DOI: 10.1111/febs.13709
关键词
adipose tissue; brain; cytokines; diabetes; hormones; JAK; STAT signaling pathway; liver; muscle; obesity; pancreas
资金
- Juvenile Diabetes Research Foundation Fellowship
- National Health and Medical Research Council of Australia [GNT1071350, GNT1024929, GNT1042735]
- Career Development Fellowship [GNT1063914]
- Monash Comprehensive Cancer Centre
- Victorian Government's Operational Infrastructure Support Program
Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.
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