Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

Pancreatic Cancer-Induced Cachexia Is Jak2-Dependent in Mice

(2014) Marine Gilabert et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia

(2013) Céline M Op den Kamp et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential

(2013) H.Q. Han et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease

(2013) Sandhya S. Thomas et al.   KIDNEY INTERNATIONAL

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

(2012) James P White et al.   Skeletal Muscle

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

(2011) Guohua Zhang et al.   EMBO JOURNAL

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

(2011) Andrea Bonetto et al.   PLoS One

Reversing Cachexia

(2010) Michael J. Tisdale   CELL

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity

(2010) Xiaonan H. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting

(2009) L. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

(2009) Xuejun Xu et al.   PLoS One

C/EBP  regulates body composition, energy balance-related hormones and tumor growth

(2008) J. Staiger et al.   CARCINOGENESIS

Cachexia: A new definition

(2008) William J. Evans et al.   CLINICAL NUTRITION