Article
Biochemistry & Molecular Biology
Vicente Barrios, Santiago Guerra-Cantera, Alvaro Martin-Rivada, Sandra Canelles, Ana Campillo-Calatayud, Eduardo Arilla-Ferreiro, Laura M. Frago, Julie A. Chowen, Jesus Argente
Summary: Leptin is involved in regulating insulin signaling and lipid metabolism in peripheral tissues. This study found that leptin activates insulin signaling and reduces muscle inflammation parameters, while decreasing the levels of non-esterified fatty acids.
Article
Nutrition & Dietetics
Tania Sanchez-Murguia, Nathaly Torres-Castillo, Lisset Magana-de la Vega, Sarai Citlalic Rodriguez-Reyes, Wendy Campos-Perez, Erika Martinez-Lopez
Summary: This study analyzed the relationship between polymorphisms in ghrelin and leptin receptor genes and dietary intake and appetite assessment. The results showed that these polymorphisms were associated with differential responses to a standardized meal, characterized by higher postprandial ghrelin levels and increased dietary sugar intake.
Article
Food Science & Technology
Monica Redondo-Puente, Raquel Mateos, Miguel A. Seguido, Joaquin Garcia-Cordero, Susana Gonzalez, Rosa M. Tarradas, Laura Bravo-Clemente, Beatriz Sarria
Summary: The combination of oat beta-glucans and green coffee may reduce hunger more efficiently than green coffee alone, according to subjective measurements. However, there were no significant differences in food intake between the two nutraceuticals.
Article
Medicine, Research & Experimental
Gabriel O. de Souza, Frederick Wasinski, Jose Donato
Summary: This study aimed to compare the responses of male and female C57BL/6 mice to various metabolic challenges. The results showed that male mice had stronger responses to food restriction and refeeding, while female mice had higher protection against diet-induced obesity. Additionally, male mice had different feeding responses to ghrelin and leptin compared to females. However, these sex differences were not explained by differences in central responsiveness or neuron fiber density.
Article
Environmental Sciences
Yang Yang, Yajing Feng, Hui Huang, Liuxin Cui, Fuqin Li
Summary: In this study, PM2.5 exposure was found to have negative effects on sperm quality and serum testosterone levels in male rats, while the IRE1 inhibitor STF083010 showed significant improvement in these effects. These findings suggest that the reproductive injury induced by PM2.5 may be mediated through the IRE1/JNK/autophagy signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Behavioral Sciences
Kyle A. Sullivan, Corena V. Grant, Kelley R. Jordan, Selina S. Vickery, Leah M. Pyter
Summary: The study found that exercise helps faster recovery from paclitaxel-induced weight loss and deficits in melanocortin signaling, but did not alleviate fatigue or inflammation. Body mass recovery was associated with the wheel running-induced recovery of body composition and associated peripheral circulating hormones.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Christopher D. Morrison, Marina A. DuVall, Cristal M. Hill, Redin A. Spann, David H. McDougal
Summary: Hypoglycemia poses a significant challenge in the clinical management of diabetes. Recent evidence suggests a role for leptin in regulating hypoglycemic counterregulation, with potential clinical utility in preventing hypoglycemia.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Neurosciences
Simone Perna, Daniele Spadaccini, Clara Gasparri, Gabriella Peroni, Vittoria Infantino, Giancarlo Iannello, Antonella Riva, Giovanna Petrangolini, Tariq A. Alalwan, Salwa Al-Thawadi, Mariangela Rondanelli
Summary: This study investigated the impact of des-acyl and acyl ghrelin (AG) on various muscular and metabolic markers and identified potential relationships and interactions with des-acylated ghrelin (DAG) in eating disorders. The findings demonstrated that higher levels of DAG were associated with poor muscle mass, insulin resistance, and depression. Additionally, the ratio of AG to DAG correlated with increased body weight, BMI, and fat mass. However, this ratio was not associated with FFMI and FFML/BMI.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Susanne Sommer, Alexandra Muenster, Jean-Alain Fehrentz, Wolfgang Hauber
Summary: This study examined the effects of shifts in motivation from hunger to satiety on outcome-selective Pavlovian-instrumental transfer (sPIT) in rats. The results showed that motivational downshift induced by outcome devaluation did not affect the sPIT effect, but other forms of motivational downshift reduced overall lever responding and magazine entries, as well as the sPIT effect.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Physiology
Kaitlin E. Burch, Kelly McCracken, Daniel J. Buck, Randall L. Davis, Dusti K. Sloan, Kathleen S. Curtis
Summary: Research suggests that weight gain after ovariectomy is associated with selective changes in metabolic hormone signaling in the CNS, including alterations in insulin and leptin receptors in different brain areas, potentially impacting weight regulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Oncology
Ryota Masuzaki, Tatsuo Kanda, Reina Sasaki, Naoki Matsumoto, Kazushige Nirei, Masahiro Ogawa, Seth J. Karp, Mitsuhiko Moriyama, Hirofumi Kogure
Summary: Hepatocellular carcinoma (HCC) is a common malignancy worldwide and the SOCS family proteins play an important role in HCC development and liver regeneration. By negatively regulating cytokine signaling, SOCS proteins can modulate cellular growth, differentiation, and immune response. In HCC treatment, SOCS proteins may be potential targets for controlling cell proliferation and immune response.
Article
Geriatrics & Gerontology
Carmen Rubio, Esther Lizarraga, David Alvarez-Cilleros, Paula Perez-Pardo, Patricia Sanmartin-Salinas, M. Val Toledo-Lobo, Carmen Alvarez, Fernando Escriva, Maria Fernandez-Lobato, Luis G. Guijarro, Angela M. Valverde, Jose M. Carrascosa
Summary: Aging in mammals disrupts homeostatic mechanisms regulating energy balance, with changes in gut microbiota potentially contributing to metabolic disorders. Older animals exhibit thinner mucosal layers and weakened gut barriers, facilitating LPS leakage, along with impaired satiating effects of CCK. These alterations resemble increased adiposity features, potentially explaining fat deposition observed in liver and heart of aged rats.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Shanmugam Murugesan, Anand Laxmi Nidamanuri
Summary: Leptin and ghrelin are two hormones that have a major impact on energy balance and food intake suppression in chickens. They also affect reproduction and immunity. The regulation mechanisms of leptin and ghrelin systems in chickens are still evolving. This review provides recent information on the role of leptin and ghrelin hormones in feed intake, body weight, reproduction, and their mechanisms of action in chickens.
WORLDS POULTRY SCIENCE JOURNAL
(2022)
Article
Neurosciences
Mei Makino, Enkhjin Ulzii, Riku Shirasaki, Jeongho Kim, Young-Jai You
Summary: Sleep and metabolism are interconnected homeostatic states, with diet regulating the sleep cycle. Specific combinations of neuropeptides released in Caenorhabditis elegans play a role in controlling satiety quiescence, allowing animals to gauge their metabolic state and induce a feeding-induced sleep-like state.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Sridevi Krishnan, Sean H. Adams, Megan G. Witbracht, Leslie R. Woodhouse, Brian D. Piccolo, Anthony P. Thomas, Elaine C. Souza, William F. Horn, Erik R. Gertz, Marta D. Van Loan, Nancy L. Keim
Summary: This study did not support the hypothesis that including dairy in long-term dietary patterns affects appetite during weight loss. Instead, weight loss itself had a modest impact on regulating hunger and satiety systems.
JOURNAL OF NUTRITION
(2021)