Review
Oncology
Ranzhiqiang Yang, Yinghui Song, Kashif Shakoor, Weimin Yi, Chuang Peng, Sulai Liu
Summary: Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumor with a poor prognosis, characterized by neoplastic transformation of intrahepatic biliary epithelial cells. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that may serve as a target for ICC treatment. Further research is needed to improve understanding of STAT3 and its role in ICC development.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Immunology
Kosuke Miyauchi, Sewon Ki, Masao Ukai, Yoshie Suzuki, Kentaro Inoue, Wataru Suda, Takeshi Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko J. Tanaka, Mariko Okada-Hatakeyama, Masato Kubo
Summary: The study suggests that STAT3 signaling in keratinocytes is essential for maintaining skin homeostasis by negatively regulating the expression of hair follicle-specific keratin genes. Expression patterns associated with dermatitis onset were observed under specific conditions, indicating the involvement of Toll-like receptor-mediated inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Jiangnan Ye, Huang Chen, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen
Summary: This study describes the design, synthesis, and structure-activity relationship studies of triaromatic heterocyclic derivatives as potent dual phosphorylation STAT3 inhibitors. The best compound 3h (HP590) was discovered with high inhibitory activity against p-Tyr(705) and p-Ser(727), resulting in the growth inhibition of gastric cancer both in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Yun Liu, Shijie Liao, Samuel Bennett, Haijun Tang, Dezhi Song, David Wood, Xinli Zhan, Jiake Xu
Summary: STAT3, a key protein involved in cell growth, differentiation, and survival, is overexpressed in osteosarcoma and various cancers. Its constitutive activation leads to upregulation of oncogenes, affecting processes such as transformation, proliferation, and metastasis.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Feng Zhou, Fanyun Zhu, Tianru Zhu, Zhucheng Zhao, Luyao Li, Shichong Lin, Haiyang Zhao, Lehe Yang, Chengguang Zhao, Liangxing Wang, Jifa Li, Xiaoying Huang
Summary: AT7519, a CDK inhibitor, exhibits great anti-tumor effects in lung cancer by blocking IL-6/STAT3 pathway and inhibiting cell proliferation and inducing apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Lan Wu, Zhizheng Li, Yanfei Li
Summary: STAT3, as a transcription factor and signaling molecule, plays an important role in cardiac disease and protection. It regulates the expression of genes involved in oxidation, apoptosis, inflammation, and fibrosis. Additionally, it is also targeted and regulated by miRNAs, which further modulate the mRNA expression profiles in cardiomyocytes and impact cardiac disease and protection.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
Xiaowei Qian, Ge Lin, Junpei Wang, Siming Zhang, Jingyi Ma, Bin Yu, Ronghua Wu, Mei Liu
Summary: The study reveals that circRNA_01477 promotes spinal astrocyte proliferation and migration after injury, and also contributes to axon growth in neurons by regulating the miRNA-3075/FosB/Stat3 axis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Chemistry, Medicinal
Lin Deng, Jianshan Mo, Yi Zhang, Keren Peng, Huaxuan Li, Shumin Ouyang, Zongbo Feng, Wei Fang, Jianwei Wei, Deqin Rong, Xiaolei Zhang, Yuanxiang Wang
Summary: Research has shown that targeting the STAT3-SH2 domain with a boronic acid group has the potential to be a new strategy for treating various human diseases. By replacing the carboxylic acid with a boronic acid, a highly potent inhibitor with stronger anticancer effects has been identified.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Sepideh Mirzaei, Mohammad Hossein Gholami, Mahmood Khaksary Mahabady, Noushin Nabavi, Amirhossein Zabolian, Seyed Mohammad Banihashemi, Amirabbas Haddadi, Maliheh Entezari, Kiavash Hushmandi, Pooyan Makvandi, Saeed Samarghandian, Ali Zarrabi, Milad Ashrafizadeh, Haroon Khan
Summary: Effective cancer therapy requires the identification of signaling networks, with STAT3 playing a significant role in promoting proliferation, invasion, chemoresistance, and metastasis in bladder cancer cells. Inhibiting STAT3 may enhance chemotherapy efficacy by overcoming chemoresistance in BC. Multiple molecular pathways and non-coding RNAs act as upstream regulators of STAT3 in BC cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Amr Allam, Marina Yakou, Lokman Pang, Matthias Ernst, Jennifer Huynh
Summary: This article discusses the relationship between cancer-associated fibroblasts (CAFs) and signal transducer and activator of transcription 3 (STAT3) in the tumor microenvironment, as well as their impact on tumor growth, immune suppression, and metastatic spread. Research suggests that CAF-intrinsic STAT3 activity is closely associated with tumor progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anwar Zaiter, Zahraa F. Audi, Fatima Shawraba, Zahraa Saker, Hisham F. Bahmad, Rami H. Nabha, Hayat Harati, Sanaa M. Nabha
Summary: Medulloblastoma is the most common malignant brain tumor of childhood, with improved overall survival rate but still lacking efficient and reliable therapeutic approaches. Understanding the role of signal transducer and activator of transcription 3 in medulloblastoma tumorigenesis is crucial for the development of effective therapies.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Summary: Th17 cells play a significant role in the pathogenesis of myocarditis, and Bazedoxifene can affect STAT3 signaling to effectively inhibit the progression of cardiac inflammation. Therefore, Bazedoxifene may be a promising therapeutic strategy for the treatment of experimental autoimmune myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Genetics & Heredity
Shixiong Wei, Jialin Li, Mingbo Tang, Kewei Zhang, Xinliang Gao, Linan Fang, Wei Liu
Summary: STAT3 is a transcription factor with important functions in normal and transformed cells, especially in cancer stem cells. It is associated with p63 protein and plays a role in regulating CSC properties.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Medicinal
Zhen Yu, Shixin Chan, Xu Wang, Ming Wang, Rui Sun, Zhenglin Wang, Xiaomin Zuo, Jiajie Chen, Huabing Zhang, Wei Chen
Summary: The combined therapy of 5-fluorouracil (5-FU) and rutaecarpine (RUT) showed significant inhibition of proliferation, migration, and anti-apoptotic ability of colorectal cancer (CRC) cells, both in vivo and in vitro. It was found that the therapy reduced the phosphorylation of STAT3 and influenced the STAT3 signaling pathway, leading to downregulation of c-Myc, CDK4, and Bcl-2 expression while enhancing cleaved caspase-3 expression.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen, Mingyao Liu, Zhengfang Yi
Summary: This study identifies a novel drug called WB436B as a selective STAT3 inhibitor for the treatment of pancreatic cancer. WB436B effectively inhibits tumor growth and metastasis, providing hope for the treatment of pancreatic cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Matthew J. Kling, Connor N. Griggs, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter, Nagendra K. Chaturvedi
Summary: The study demonstrated the potential therapeutic efficacy of targeting dysregulated protein synthesis pathways by inhibiting MYCN and mTOR signaling simultaneously in NB, particularly showing significant effects on MYCN-amplified NB cells. Further preclinical evaluation is needed to assess the clinical utility of this targeted therapy for high-risk NB patients.
Article
Oncology
Heyu Song, Shaoyan Xi, Yingling Chen, Suravi Pramanik, Jiping Zeng, Shrabasti Roychoudhury, Hannah Harris, Anum Akbar, Salma S. Elhag, Donald W. Coulter, Sutapa Ray, Kishor K. Bhakat
Summary: MB tumors exhibit elevated levels of the nucleosome remodeling FACT complex and DNA repair enzyme APE1, which promote repair of DNA damage induced by radiation and cisplatin. Targeting the FACT complex with CBL0137 enhances the potency of cisplatin and radiation, leading to the suppression of MB tumor growth.
Article
Genetics & Heredity
Kishor K. Bhakat, Sutapa Ray
Summary: Genomic DNA in the nucleus is wrapped around nucleosomes, consisting of core histones. The histone chaperone complex FACT is involved in nucleosome remodeling during processes like transcription and DNA repair, playing a crucial role in various repair pathways. Overexpression of FACT in cancer is associated with drug resistance and poor prognosis, while inhibitors like curaxins show promise in sensitizing cancer to chemotherapy and radiation.
Article
Gastroenterology & Hepatology
Yi Li, Jianping Chen, Andrew A. Bolinger, Haiying Chen, Zhiqing Liu, Yingzi Cong, Allan R. Brasier, Irina Pinchuk, Bing Tian, Jia Zhou
Summary: Inflammatory bowel disease (IBD) is a serious chronic gastrointestinal disease, with long-term inflammation contributing to neoplastic transformation and colorectal cancer development. The discovery of new small molecule drugs targeting specific pathways in mucosal inflammation offers hope for the treatment of IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Medicine, General & Internal
Sutapa Ray, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Sidharth Mahapatra
Summary: Medulloblastoma is the most common malignant central nervous system tumor in pediatric patients. Tumors can be divided into average and high-risk status based on age, metastasis at diagnosis, and extent of surgical resection. High-throughput screening has allowed for the identification of four primary subgroups, each with further subdivisions based on cytogenetic and epigenetic events. Exploiting these genetic aberrations may lead to novel targeted therapeutics.
Article
Biochemistry & Molecular Biology
Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A. Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K. Singh, Kishor K. Bhakat
Summary: This study identifies a novel role for the protein APE1 in regulating stable G4 formation and KRAS expression in PDAC, suggesting that G4 structures could be potential prognostic markers and therapeutic targets for PDAC.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemical Research Methods
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: Airway remodeling in patients with asthma is associated with leukocyte numbers and remodeling markers. Patients with lower FEV1 have distinct dynamic responses to allergens.
CLINICAL PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: This study analyzed metabolites in bronchoalveolar fluid (BALF) during a bronchial antigen challenge and identified distinct metabolic responses, providing insight into pathogenic and protective subtypes in allergic asthma.
Editorial Material
Virology
Allan R. Brasier
Article
Biochemistry & Molecular Biology
Dianhua Qiao, Melissa Skibba, Xiaofang Xu, Allan R. Brasier
Summary: Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently, the unfolded protein response (UPR) was found to trigger EMP through the IRE1 alpha-XBP1s axis, enhancing glucose shunting to protein N glycosylation. By identifying the genomic targets of XBP1s using CUT&RUN, it was discovered that XBP1s peaks were located near various promoters of genes controlling Rho-GTPase signaling, N-linked glycosylation, and ER-Golgi transport. Moreover, the IRE1 alpha-XBP1s pathway was shown to regulate mesenchymal transcription factors and hexosamine biosynthesis in EMP by recruiting activated RNA Pol II to GC-rich promoters.
NUCLEIC ACIDS RESEARCH
(2023)
Editorial Material
Medicine, Research & Experimental
Allan R. Brasier
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Kyle A. Rohrer, Heyu Song, Anum Akbar, Yingling Chen, Suravi Pramanik, Phillip J. Wilder, Erin M. McIntyre, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Don W. Coulter, Sutapa Ray
Summary: Medulloblastoma (MB) is a common childhood malignant brain tumor that accounts for a significant percentage of pediatric central nervous system tumors. This study reveals the functional role of activated STAT3 in promoting MB tumorigenesis and chemoresistance by inducing the oncogene MYC. Inhibiting STAT3 can reduce the growth and survival of MB cells and improve treatment efficacy, especially in high-risk MYC-amplified tumors.
Review
Medicine, Research & Experimental
Allan. R. R. Brasier, Shannon. L. L. Casey, Peggy Hatfield, Patrick. W. W. Kelly, Whitney. A. A. Sweeney, Marin Schweizer, Bo Liu, Elizabeth. S. S. Burnside
Summary: This study proposes a model for developing leadership in translational teams (TTs) from team formation to dissemination and implementation. It identifies the stable impact of leadership behaviors on team development and emphasizes the importance of ongoing reflection, evaluation, and practice to enhance leadership skills. The study also provides a comprehensive multi-level evaluation framework to track the growth of TT leadership skills.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Shannon L. Casey, Felice Resnik, Betsy Rolland, Elizabeth S. Burnside
Summary: Successful translation involves the application of research and product development to advance healthcare interventions. Training in team skills and attitudes can enhance translational team performance. Interdisciplinary teams undergo developmental phases, with each phase promoting knowledge generation and translation. Antecedents of stage-dependent competencies and assessment rubrics can guide training interventions for improving performance in the clinical context.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Elizabeth S. Burnside, Betsy Rolland
Summary: A translational team is a type of interdisciplinary team that aims to improve human health. Understanding how to promote team performance in the areas of affect, communication, management, collaborative problem-solving, and leadership is essential. This study conducted a literature review to identify key competencies that enhance team performance and develop strategies for training interventions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)