期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 12, 期 5, 页码 532-544出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.15153
关键词
Stat3
资金
- National Institutes of Health [R56A1094027, P20GM103496]
- American Association of Immunologists Careers in Immunology Fellowship Program
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI094027, R56AI116255] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103496] Funding Source: NIH RePORTER
Stat3 has been studied extensively as a transcription factor, however the finding that Stat3 also localizes to mitochondria has opened a new area to discover non-classical functions. Here we review the current knowledge of mitochondrial Stat3 as a regulator of the electron transport chain (ETC) and its impact on mitochondrial production of ATP and ROS. We also describe recent findings identifying Stat3 as a regulator of mitochondrial Ca' homeostasis through its effect on the ETC. It is becoming evident that these non -classical functions of Stat3 can have a major impact on cancer progression, cardiovascular diseases, and inflammatory diseases. Therefore, mitochondrial Stat3 functions challenge the current design of therapies that solely target Stat3 as a transcription factor and suggest the need for design thinking, which leads to the development of novel strategies, to intervene the Stat3 pathway.
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