Metabolic determinants of lupus pathogenesis

Aquaporins in Renal Diseases

(2019) Jinzhao He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

(2019) Caterina E. Faliti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

(2019) Priya Rangan et al.   Cell Reports

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus

(2019) Yao Li et al.   CLINICAL SCIENCE

Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal

(2019) Doua Azzouz et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathogenesis and treatment of autoimmune rheumatic diseases

(2019) Eric Liu et al.   CURRENT OPINION IN RHEUMATOLOGY

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

(2019) Noelia Keiran et al.   NATURE IMMUNOLOGY

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus

(2019) Federica Furini et al.   Frontiers in Pharmacology

Inhibition of fatty acid metabolism by etomoxir or TOFA suppresses murine dendritic cell activation without affecting viability

(2019) Connie C. Qiu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells

(2019) Anton A. Titov et al.   JOURNAL OF IMMUNOLOGY

The cytokine network type I IFN-IL-27-IL-10 is augmented in murine and human lupus

(2019) Michael H. Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus

(2019) Yiyangzi Ma et al.   MOLECULAR MEDICINE

Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis

(2019) Michihito Kono et al.   Arthritis & Rheumatology

Fecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus

(2019) Qiong Zhang et al.   Frontiers in Immunology

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

(2019) Wei Li et al.   Frontiers in Immunology

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

(2019) Motoyoshi Nagai et al.   CELL

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

(2019) Nicholas Collins et al.   CELL

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

The Pathogenic Role of Dysregulated Epigenetic Modifications in Autoimmune Diseases

(2019) Haijing Wu et al.   Frontiers in Immunology

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

(2019) Stefano Angiari et al.   Cell Metabolism

Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses

(2019) Carla Di Dedda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Induction of metabolic quiescence defines the transitional to follicular B cell switch

(2019) Jocelyn R. Farmer et al.   Science Signaling

Metabolic regulation of pathogenic autoimmunity: therapeutic targeting

(2019) Xiangyu Teng et al.   CURRENT OPINION IN IMMUNOLOGY

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation

(2018) Brenda Raud et al.   Cell Metabolism

Biochemistry of proinflammatory macrophage activation

(2018) Yannic Nonnenmacher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overview

(2018) Zijun Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

(2018) André L. Saraiva et al.   FASEB JOURNAL

Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis

(2018) Carlson Tsui et al.   IMMUNITY

Metabolic Barriers to T Cell Function in Tumors

(2018) Ayaka Sugiura et al.   JOURNAL OF IMMUNOLOGY

TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity

(2018) Nipun Jayachandran et al.   JOURNAL OF IMMUNOLOGY

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

(2018) Im-Hong Sun et al.   JOURNAL OF IMMUNOLOGY

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

The association between metabolic syndrome and its components with systemic lupus erythematosus: a comprehensive systematic review and meta-analysis of observational studies

(2018) J Hallajzadeh et al.   LUPUS

Increased serum leptin levels are associated with metabolic syndrome and carotid intima media thickness in premenopausal systemic lupus erythematosus patients without clinical atherosclerotic vascular events

(2018) S Demir et al.   LUPUS

Alterations of oxygen consumption and extracellular acidification rates by glutamine in PBMCs of SLE patients

(2018) Hui-Ting Lee et al.   MITOCHONDRION

Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27

(2018) Heeju Ryu et al.   NATURE IMMUNOLOGY

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells

(2018) Michihito Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum adipokine levels and associations with patient-reported fatigue in systemic lupus erythematosus

(2018) Mary A. Mahieu et al.   RHEUMATOLOGY INTERNATIONAL

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

C1q restrains autoimmunity and viral infection by regulating CD8+T cell metabolism

(2018) Guang Sheng Ling et al.   SCIENCE

Metabolic Links between Plasma Cell Survival, Secretion, and Stress

(2018) Wing Y. Lam et al.   TRENDS IN IMMUNOLOGY

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

(2018) Nicole M. Chapman et al.   Nature Communications

Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages

(2018) Shuhong Han et al.   Frontiers in Immunology

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

(2018) Bo Ruem Yoon et al.   Frontiers in Immunology

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Adipokine interactions promote the pathogenesis of systemic lupus erythematosus

(2018) Durga Chougule et al.   CYTOKINE

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

(2018) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation

(2018) Michihito Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

(2018) Fabrizia Bonacina et al.   Nature Communications

Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs

(2018) Junchen Chen et al.   PLOS BIOLOGY

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis

(2018) Desmond Y.H. Yap et al.   JOURNAL OF RHEUMATOLOGY

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

(2018) Simone Caielli et al.   NATURE MEDICINE

A prospective study of obesity and risk of systemic lupus erythematosus (SLE) among Black women

(2018) Yvette C Cozier et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

(2018) Seung-Chul Choi et al.   Nature Communications

Calcium/calmodulin-dependent protein kinase 4 promotes GLUT1-dependent glycolysis in systemic lupus erythematosus

(2018) Tomohiro Koga et al.   Arthritis & Rheumatology

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells

(2018) Andrew P. Ferretti et al.   Frontiers in Immunology

Discovery and development of small molecule modulators targeting glutamine metabolism

(2018) Lei Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

From zero to sixty and back to zero again: the metabolic life of B cells

(2018) Munir Akkaya et al.   CURRENT OPINION IN IMMUNOLOGY

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

(2017) Lifan Xu et al.   IMMUNITY

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

(2017) Jonatan Ersching et al.   IMMUNITY

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift

(2017) Bruna Miglioranza Scavuzzi et al.   IMMUNOLOGIC RESEARCH

Prevalence and risk of metabolic syndrome in patients with systemic lupus erythematosus: A meta-analysis

(2017) Chong Sun et al.   International Journal of Rheumatic Diseases

Serum Adiponectin Levels in Patients With Systemic Lupus Erythematosus

(2017) Ahmed Ali Dini et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Association of leptin and leptin receptor gene polymorphisms with systemic lupus erythematosus in a Chinese population

(2017) Hong-Miao Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin Suppresses Systemic Autoimmunity inRoquinsan/sanMice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3

(2017) Seon-Yeong Lee et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Commits Differentiation of Human CD27+IgD+B Cells to Plasmablasts or CD27−IgD−Cells

(2017) Masataka Torigoe et al.   JOURNAL OF IMMUNOLOGY

Fatty acid synthase regulates the pathogenicity of Th17 cells

(2017) Kathryne E. Young et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

(2017) Yushi Yao et al.   Journal of Translational Medicine

Leptin levels in patients with systemic lupus erythematosus inversely correlate with regulatory T cell frequency

(2017) X Wang et al.   LUPUS

Association between circulating leptin levels and systemic lupus erythematosus: an updated meta-analysis

(2017) Y H Lee et al.   LUPUS

Analysis of the free fatty acid metabolome in the plasma of patients with systemic lupus erythematosus and fever

(2017) Tae Hwan Shin et al.   Metabolomics

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2017) Tao Xu et al.   NATURE

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

(2017) Kai Yang et al.   NATURE

D-mannose induces regulatory T cells and suppresses immunopathology

(2017) Dunfang Zhang et al.   NATURE MEDICINE

Leptin in the interplay of inflammation, metabolism and immune system disorders

(2017) Vanessa Abella et al.   Nature Reviews Rheumatology

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Fine tuning of immunometabolism for the treatment of rheumatic diseases

(2017) Jillian P. Rhoads et al.   Nature Reviews Rheumatology

Immunometabolism in systemic lupus erythematosus

(2017) Laurence Morel   Nature Reviews Rheumatology

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1

(2017) Nanhai He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and the risk of systemic lupus erythematosus among women in the Nurses’ Health Studies

(2017) Sara K. Tedeschi et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Amino-acid transporters in T-cell activation and differentiation

(2017) Wenkai Ren et al.   Cell Death & Disease

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

(2017) Woelsung Yi et al.   Nature Communications

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Review: Metabolic Control of Immune System Activation in Rheumatic Diseases

(2017) Andras Perl   Arthritis & Rheumatology

Intestinal Dysbiosis Is Associated with Altered Short-Chain Fatty Acids and Serum-Free Fatty Acids in Systemic Lupus Erythematosus

(2017) Javier Rodríguez-Carrio et al.   Frontiers in Immunology

Leptin as a predictor of metabolic syndrome in prepubertal children

(2017) Isabel Madeira et al.   Archives of Endocrinology Metabolism

Serum levels of adiponectin and leptin as biomarkers of proteinuria in lupus nephritis

(2017) Valeria Diaz-Rizo et al.   PLoS One

Urinary metabolomic study of systemic lupus erythematosus based on gas chromatography/mass spectrometry

(2016) Bei Yan et al.   BIOMEDICAL CHROMATOGRAPHY

Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treated with fumaric acid esters

(2016) A.M. Saracino et al.   BRITISH JOURNAL OF DERMATOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

T cells in Systemic Lupus Erythematosus

(2016) Abel Suárez-Fueyo et al.   CURRENT OPINION IN IMMUNOLOGY

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

(2016) Valerie A. Gerriets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Cholesterol Accumulation in CD11c + Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease

(2016) Ayaka Ito et al.   IMMUNITY

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

(2016) Hung D. Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

(2016) Terri N. Iwata et al.   JOURNAL OF IMMUNOLOGY

Fumaric acid ester treatment in cutaneous lupus erythematosus (CLE): a prospective, open-label, phase II pilot study

(2016) A Kuhn et al.   LUPUS

Serum metabolomic profiling in patients with systemic lupus erythematosus by GC/MS

(2016) Bei Yan et al.   Modern Rheumatology

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Plasma cells as an innovative target in autoimmune disease with renal manifestations

(2016) Falk Hiepe et al.   Nature Reviews Nephrology

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis

(2016) Anders A. Bengtsson et al.   PLoS One

Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

(2016) Elaine V. Lourenço et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function

(2016) Nyamdelger Sukhbaatar et al.   TRENDS IN IMMUNOLOGY

Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus

(2016) Zhixing He et al.   Gut Pathogens

NMR based serum metabolomics reveals a distinctive signature in patients with Lupus Nephritis

(2016) Anupam Guleria et al.   Scientific Reports

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

(2016) In Young Choi et al.   Cell Reports

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal

(2016) William C. Adams et al.   Cell Reports

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

Dimethyl Fumarate: A Review in Relapsing-Remitting MS

(2015) Emma D. Deeks   DRUGS

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation

(2015) Bernardo S. Reis et al.   JOURNAL OF IMMUNOLOGY

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

(2015) Andras Perl et al.   Metabolomics

What is damaging the kidney in lupus nephritis?

(2015) Anne Davidson   Nature Reviews Rheumatology

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Amino acid management in cancer

(2015) Zhi-Yang Tsun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity

(2015) Jin-Young Choi et al.   Arthritis & Rheumatology

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

(2015) Christian Lood et al.   PLoS One

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus

(2014) Edward Doherty et al.   ANTIOXIDANTS & REDOX SIGNALING

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Association between urinary adiponectin level and renal involvement in systemic lupus erythematous

(2014) Maryam Loghman et al.   International Journal of Rheumatic Diseases

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Faslpr Mice

(2014) Y. Fujita et al.   JOURNAL OF IMMUNOLOGY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Bcl-6 directly represses the gene program of the glycolysis pathway

(2014) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Leptin Enhances Availability of Apoptotic Cell-Derived Self-Antigen in Systemic Lupus Erythematosus

(2014) Gil Amarilyo et al.   PLoS One

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

(2014) A. Hevia et al.   mBio

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Effector T cells require fatty acid metabolism during murine graft-versus-host disease

(2013) C. A. Byersdorfer et al.   BLOOD

Requirement for Rictor in homeostasis and function of mature B lymphoid cells

(2013) K. Lee et al.   BLOOD

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Leptin promotes lupus T-cell autoimmunity

(2013) Gil Amarilyo et al.   CLINICAL IMMUNOLOGY

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Control of TFH cell numbers: why and how?

(2013) Alvin Pratama et al.   IMMUNOLOGY AND CELL BIOLOGY

B Cell-Specific Deficiencies in mTOR Limit Humoral Immune Responses

(2013) S. Zhang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

(2013) Andras Perl   Nature Reviews Rheumatology

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans

(2013) Sudhir Gupta et al.   Immunity & Ageing

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

HDL and ApoA-I inhibit antigen presentation-mediated T cell activation by disrupting lipid rafts in antigen presenting cells

(2012) Shu-hui Wang et al.   ATHEROSCLEROSIS

Protein kinase Cβ is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement

(2012) Derek Blair et al.   BIOCHEMICAL JOURNAL

Regulation of Hematopoietic Stem and Progenitor Cell Mobilization by Cholesterol Efflux Pathways

(2012) Marit Westerterp et al.   Cell Stem Cell

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor  

(2012) D. J. Perry et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Weight loss and improvements in fatigue in systemic lupus erythematosus: a controlled trial of a low glycaemic index diet versus a calorie restricted diet in patients treated with corticosteroids

(2012) RJ Davies et al.   LUPUS

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Disturbances Associated with Systemic Lupus Erythematosus

(2012) Tianfu Wu et al.   PLoS One

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids

(2011) M. McMahon et al.   ANNALS OF THE RHEUMATIC DISEASES

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Immunologic characteristics of intrarenal T cells: Trafficking of expanded CD8+ T cell β-chain clonotypes in progressive lupus nephritis

(2011) Robert Winchester et al.   ARTHRITIS AND RHEUMATISM

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Leptin, adiponectin and vascular stiffness parameters in women with systemic lupus erythematosus

(2011) Marta Vadacca et al.   Internal and Emergency Medicine

Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway

(2011) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

An analysis of the metabolic syndrome phenotype in systemic lupus erythematosus

(2011) B Parker et al.   LUPUS

Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q

(2011) CC Mok et al.   LUPUS

Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters

(2011) J Bogaczewicz et al.   LUPUS

1H NMR-based metabolomic study of metabolic profiling for systemic lupus erythematosus

(2011) X Ouyang et al.   LUPUS

Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis

(2011) C. C. Mok et al.   RHEUMATOLOGY

Abnormalities of T cell signaling in systemic lupus erythematosus

(2011) Vaishali R Moulton et al.   ARTHRITIS RESEARCH & THERAPY

Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling

(2010) Meidan Goldfinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus

(2010) Wen Liang Fang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Modulation of Lupus Phenotype by Adiponectin Deficiency in Autoimmune Mouse Models

(2010) Jennifer Parker et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases

(2010) Éric Toussirot et al.   MEDIATORS OF INFLAMMATION

Apolipoprotein A-I and Its Role in Lymphocyte Cholesterol Homeostasis and Autoimmunity

(2009) Ashley J. Wilhelm et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

(2009) Laurent Yvan-Charvet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Serum adipokine levels in patients with systemic lupus erythematosus

(2009) Juan B. De Sanctis et al.   AUTOIMMUNITY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

ATP-Binding Cassette Transporter G1 Negatively Regulates Thymocyte and Peripheral Lymphocyte Proliferation

(2009) Allison J. Armstrong et al.   JOURNAL OF IMMUNOLOGY

Leptin and ghrelin in Korean systemic lupus erythematosus

(2009) H-A. Kim et al.   LUPUS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION