Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
George C. Drosos, George Konstantonis, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study examined the eligibility for lipid-lowering therapy (LLT) in SLE patients according to SCORE, with the addition of vascular ultrasound and disease-related features. The results showed that disease-related and ultrasound features can help improve LLT decision making in SLE.
Article
Cell Biology
Jin Kyun Park, Ye Ji Lee, Ji Soo Park, Eun Bong Lee, Yeong Wook Song
Summary: In patients with SLE, CD47 expression is upregulated in monocytes and correlates with disease activity. CD47 contributes to augmented inflammatory responses in SLE, suggesting that targeting CD47 may be a novel treatment approach for SLE.
Article
Rheumatology
Sarfaraz Hasni, Yenealem Temesgen-Oyelakin, Michael Davis, Jun Chu, Elaine Poncio, Mohammad Naqi, Sarthak Gupta, Xinghao Wang, Christopher Oliveira, Dillon Claybaugh, Amit Dey, Shajia Lu, Philip Carlucci, Monica Purmalek, Zerai G. Manna, Yinghui Shi, Isabel Ochoa-Navas, Jinguo Chen, Amrita Mukherjee, Kyu Lee Han, Foo Cheung, Galina Koroleva, Yasmine Belkaid, John S. Tsang, Richard Apps, Donald E. Thomas, Theo Heller, Massimo Gadina, Martin P. Playford, Xiaobai Li, Nehal N. Mehta, Mariana J. Kaplan
Summary: The study aimed to investigate the effects of the peroxisome proliferator activated receptor-gamma agonist pioglitazone (PGZ) on vascular function and cardiometabolic parameters in SLE patients. The results showed that PGZ significantly improved vascular stiffness and metabolic parameters in SLE patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Haiping Xing, Haiyu Pang, Tian Du, Xufei Yang, Jing Zhang, Mengtao Li, Shuyang Zhang
Summary: In this study, atherosclerotic risk prediction model was built for SLE patients using RNA sequencing and differential expression analysis. The model, incorporating one gene and two clinical factors, demonstrated relatively high discrimination and calibration performance, providing valuable assistance for identifying atherosclerosis in SLE patients, especially asymptomatic ones.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Leda Coelewij, Kirsty E. Waddington, George A. Robinson, Elvira Chocano, Thomas McDonnell, Filipa Farinha, Junjie Peng, Pierre Donnes, Edward Smith, Sara Croca, Jyoti Bakshi, Maura Griffin, Andrew Nicolaides, Anisur Rahman, Elizabeth C. Jury, Ines Pineda-Torra
Summary: This study found that patients with SLE have global changes in their lipoprotein profiles, but standard serum lipid measurements cannot accurately predict their risk of cardiovascular disease. Serum metabolites may be promising biomarkers to uncover the multi-metabolic phenotypes of subclinical atherosclerosis in SLE patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Mengmeng Xiang, Yilun Wang, Zhanyan Gao, Jie Wang, Qian Chen, Zhan Sun, Jun Liang, Jinhua Xu
Summary: This study used Mendelian randomization to assess the causal correlations between 41 inflammatory cytokines and systemic lupus erythematosus (SLE). The results suggested that CTACK and IL-17 may be associated with the risk of SLE, while several other inflammatory cytokines may be consequences of SLE development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yang Ding, Shasha Fan, Yi Tang, Mengjiao He, Mingyang Ren, Yunjuan Shi, Xiaohua Tao, Wei Lu
Summary: We conducted a two-sample Mendelian randomization analysis to assess the causal effects of blood lipid levels on systemic lupus erythematosus (SLE). Using instrumental variables (IVs) from a published genome-wide association study (GWAS), we found no causal association between abnormal blood lipids and SLE, as well as no causal effect between SLE and LDL cholesterol and Apolipoprotein B. However, there was some evidence suggesting that SLE exerted a causal effect on lowering HDL cholesterol, Apolipoprotein A-I, and triglyceride levels.
Review
Immunology
Christopher B. Oliveira, Mariana J. Kaplan
Summary: Patients with systemic lupus erythematosus (SLE) have a higher risk of cardiovascular diseases, and traditional risk factors cannot fully explain this increased risk. SLE-specific factors, such as immune dysregulation and inflammation, may contribute to the development of cardiovascular diseases in SLE patients.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Rheumatology
Jorge Luis Gamboa, Daniel Carranza-Leon, Rachelle Crescenzi, Michael Pridmore, Dungeng Peng, Adriana Marton, Annette Oeser, Cecilia P. Chung, Jens Titze, Charles Michael Stein, Michelle Ormseth
Summary: This study found that patients with SLE have increased intermuscular adipose tissue (IMAT) accumulation, which is associated with greater fatigue and reduced physical activity. Interventions targeting muscle quality may be effective in alleviating fatigue in SLE patients.
LUPUS SCIENCE & MEDICINE
(2022)
Review
Immunology
Xiaohong Lu, YanHua Wang, Jing Zhang, Dan Pu, Nan Hu, Jing Luo, Qi An, Lan He
Summary: The systematic review and meta-analysis found that patients with systemic lupus erythematosus (SLE) have a higher risk of developing cardiovascular disease (CVD) compared to the general or healthy population, and the risk of CVD in lupus nephritis (LN) patients is significantly higher than in SLE patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yudong Liu, Xue Yu, Wenduo Zhang, Xuan Zhang, Min Wang, Fusui Ji
Summary: Systemic lupus erythematosus (SLE) is strongly associated with cardiovascular disease (CVD), and the interaction between immune dysregulation and traditional CVD risk factors plays a significant role in the development of premature atherosclerosis and CVD in SLE. Abnormal systemic inflammation in SLE can lead to lipid profile and function irregularities, further promoting a pro-atherosclerotic environment. Profound immune dysregulation, including excessive type I interferon burden, aberrant macrophage, platelet and complements activation, etc., contributes to accelerated CVD in SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Geriatrics & Gerontology
Gregory Kuchcinski, Theodor Rumetshofer, Kristoffer A. Zervides, Renaud Lopes, Morgan Gautherot, Jean-Pierre Pruvo, Anders A. Bengtsson, Oskar Hansson, Andreas Jonsen, Pia C. Maly Sundgren
Summary: Using a deep-learning BrainAGE model, evidence of increased brain aging in SLE patients has been provided, reflecting neuronal damage and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Rheumatology
Yossra A. Suliman, Suzanne Kafaja, John Fitzgerald, Ximena Wortsman, Jonathan Grotts, Marco Matucci-Cerrinic, Veena K. Ranganath, Daniel E. Furst
CLINICAL RHEUMATOLOGY
(2018)
Article
Rheumatology
Robert Ike, Amrutha Baskaran, Jeannie Chao, Andrew L. Concoff, Christopher W. Wu, Bob Sun, Paul H. Brion, Erin L. Arnold, David J. Klashman, John FitzGerald, Kenneth C. Kalunian
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2019)
Article
Rheumatology
John D. FitzGerald, Ted R. Mikuls, Tuhina Neogi, Jasvinder A. Singh, Mark Robbins, Puja P. Khanna, Amy S. Turner, Rachel Myslinski, Lisa G. Suter
ARTHRITIS CARE & RESEARCH
(2018)
Article
Rheumatology
Daniel F. Battafarano, Marcia Ditmyer, Marcy B. Bolster, John D. Fitzgerald, Chad Deal, Ann R. Bass, Rodolfo Molina, Alan R. Erickson, Jonathan S. Hausmann, Marisa Klein-Gitelman, Lisa F. Imundo, Benjamin J. Smith, Karla Jones, Kamilah Greene, Seetha U. Monrad
ARTHRITIS CARE & RESEARCH
(2018)
Letter
Medicine, General & Internal
Liron Caplan, John FitzGerald
JAMA INTERNAL MEDICINE
(2018)
Review
Rheumatology
Monica Zell, Dawen Zhang, John FitzGerald
CURRENT OPINION IN RHEUMATOLOGY
(2019)
Editorial Material
Rheumatology
Jinoos Yazdany, Liron Caplan, John Fitzgerald, Gabriela Schmajuk
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Rheumatology
David Bursill, William J. Taylor, Robert Terkeltaub, Abhishek Abhishek, Alexander K. So, Ana Beatriz Vargas-Santos, Angelo Lino Gaffo, Ann Rosenthal, Anne-Kathrin Tausche, Anthony Reginato, Bernhard Manger, Carlo Scire, Carlos Pineda, Caroline van Durme, Ching-Tsai Lin, Congcong Yin, Daniel Arthur Albert, Edyta Biernat-Kaluza, Edward Roddy, Eliseo Pascual, Fabio Becce, Fernando Perez-Ruiz, Francisca Sivera, Frederic Liote, Georg Schett, George Nuki, Georgios Filippou, Geraldine McCarthy, Geraldo da Rocha Castelar Pinheiro, Hang-Korng Ea, Helena De Almeida Tupinamba, Hisashi Yamanaka, Hyon K. Choi, James Mackay, James R. ODell, Janitzia Vazquez Mellado, Jasvinder A. Singh, John D. Fitzgerald, Lennart T. H. Jacobsson, Leo Joosten, Leslie R. Harrold, Lisa Stamp, Mariano Andres, Marwin Gutierrez, Masanari Kuwabara, Mats Dehlin, Matthijs Janssen, Michael Doherty, Michael S. Hershfield, Michael Pillinger, N. Lawrence Edwards, Naomi Schlesinger, Nitin Kumar, Ole Slot, Sebastien Ottaviani, Pascal Richette, Paul A. MacMullan, Peter T. Chapman, Peter E. Lipsky, Philip Robinson, Puja P. Khanna, Rada N. Gancheva, Rebecca Grainger, Richard J. Johnson, Ritch Te Kampe, Robert T. Keenan, Sara K. Tedeschi, Seoyoung Kim, Sung Jae Choi, Theodore R. Fields, Thomas Bardin, Till Uhlig, Tim Jansen, Tony Merriman, Tristan Pascart, Tuhina Neogi, Viola Kluck, Worawit Louthrenoo, Nicola Dalbeth
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Article
Biochemical Research Methods
Bijie Bai, Hongda Wang, Tairan Liu, Yair Rivenson, John FitzGerald, Aydogan Ozcan
JOURNAL OF BIOPHOTONICS
(2020)
Article
Rheumatology
John D. FitzGerald, Nicola Dalbeth, Ted Mikuls, Romina Brignardello-Petersen, Gordon Guyatt, A. M. Abeles, Allan C. Gelber, Leslie R. Harrold, Dinesh Khanna, Charles King, Gerald Levy, Caryn Libbey, David Mount, Michael H. Pillinger, Ann Rosenthal, Jasvinder A. Singh, James Edward Sims, Benjamin J. Smith, Neil S. Wenger, Sangmee Sharon, Abhijeet Danve, Puja P. Khanna, Seoyoung C. Kim, Aleksander Lenert, Samuel Poon, Anila Qasim, Shiv T. Sehra, Tarun Sudhir Kumar Sharma, Michael Toprover, Marat Turgunbaev, Linan Zeng, Mary Ann Zhang, Amy S. Turner, Tuhina Neogi
ARTHRITIS CARE & RESEARCH
(2020)
Article
Rheumatology
John D. FitzGerald, Nicola Dalbeth, Ted Mikuls, Romina Brignardello-Petersen, Gordon Guyatt, A. M. Abeles, Allan C. Gelber, Leslie R. Harrold, Dinesh Khanna, Charles King, Gerald Levy, Caryn Libbey, David Mount, Michael H. Pillinger, Ann Rosenthal, Jasvinder A. Singh, James Edward Sims, Benjamin J. Smith, Neil S. Wenger, Sangmee Sharon Bae, Abhijeet Danve, Puja P. Khanna, Seoyoung C. Kim, Aleksander Lenert, Samuel Poon, Anila Qasim, Shiv T. Sehra, Tarun Sudhir Kumar Sharma, Michael Toprover, Marat Turgunbaev, Linan Zeng, Mary Ann Zhang, Amy S. Turner, Tuhina Neogi
ARTHRITIS & RHEUMATOLOGY
(2020)
Letter
Rheumatology
John FitzGerald, Romina Brignardello-Petersen, Nicola Dalbeth, Ted Mikuls, Tuhina Neogi, Gordon Guyatt
ARTHRITIS CARE & RESEARCH
(2020)
Review
Rheumatology
Linan Zeng, Anila Qasim, Tuhina Neogi, John D. Fitzgerald, Nicola Dalbeth, Ted R. Mikuls, Gordon H. Guyatt, Romina Brignardello-Petersen
Summary: Through network meta-analysis, it was found that canakinumab may be the relatively most effective option, while intravenous or intramuscular corticosteroids may be the second best in pain reduction. Acetic acid derivative NSAIDs may be superior to ibuprofen NSAIDs in improving joint swelling and patient global assessment.
ARTHRITIS CARE & RESEARCH
(2021)
Letter
Rheumatology
Tuhina Neogi, Nicola Dalbeth, Ted R. Mikuls, Amy S. Turner, John D. FitzGerald
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Evan A. Choate, Gurjit S. Kaeley, Jenny Brook, Roy D. Altman, John D. FitzGerald, Astrid R. Floegel-Shetty, David A. Elashoff, Veena K. Ranganath