Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer

(2017) Venkatrao Vantaku et al.   Oncotarget

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments

(2016) Haiyan Peng et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

(2016) Ulf Schulze-Topphoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

(2016) Ralf A. Linker et al.   Therapeutic Advances in Chronic Disease

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

(2014) Alexander A Shestov et al.   eLife

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Detection of Metabolites of Fumaric Acid Esters in Human Urine: Implications for Their Mode of Action

(2008) Martin Rostami-Yazdi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY