TAPP Adaptors Control B Cell Metabolism by Modulating the Phosphatidylinositol 3-Kinase Signaling Pathway: A Novel Regulatory Circuit Preventing Autoimmunity

Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

(2018) Anuja Sathe et al.   PLoS One

Metabolic Regulation of the Immune Humoral Response

(2017) Mark Boothby et al.   IMMUNITY

Immunometabolism in systemic lupus erythematosus

(2017) Laurence Morel   Nature Reviews Rheumatology

B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice

(2016) Nipun Jayachandran et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination

(2016) Robert K. Abbott et al.   JOURNAL OF IMMUNOLOGY

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors

(2016) Cristina Saura et al.   Cancer Discovery

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling

(2015) Hongzhao Li et al.   CELLULAR SIGNALLING

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens

(2015) Janie Akerlund et al.   JOURNAL OF AUTOIMMUNITY

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Inhibition of PI3Kδ Reduces Kidney Infiltration by Macrophages and Ameliorates Systemic Lupus in the Mouse

(2014) Abel Suárez-Fueyo et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

How does SHIP1/2 balance PtdIns(3,4)P2and does it signal independently of its phosphatase activity?

(2013) Jingwei Xie et al.   BIOESSAYS

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production

(2012) Ivan Landego et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

p110  Phosphoinositide 3-Kinase Represses IgE Switch by Potentiating BCL6 Expression

(2012) T.-t. Zhang et al.   JOURNAL OF IMMUNOLOGY

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

(2012) Dinis Pedro Calado et al.   NATURE IMMUNOLOGY

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

(2012) K. Lin et al.   Science Signaling

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2in regulating insulin sensitivity defined by knock-in analysis

(2011) Stephan Wullschleger et al.   BIOCHEMICAL JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of Phosphatidylinositol 3,4,5-Trisphosphate Production Is a Key Determinant of B Cell Anergy

(2009) Cecille D. Browne et al.   IMMUNITY

Phosphoinositide 3-kinase-regulated adapters in lymphocyte activation

(2009) Ting-ting Zhang et al.   IMMUNOLOGICAL REVIEWS

PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity

(2007) Kewei Ma et al.   CELLULAR SIGNALLING