P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

(2016) Patrick Blanco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity

(2016) Phillip P. Domeier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activin A programs the differentiation of human TFH cells

(2016) Michela Locci et al.   NATURE IMMUNOLOGY

CXCL13 is a plasma biomarker of germinal center activity

(2016) Colin Havenar-Daughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus

(2015) Lino L. Teichmann et al.   IMMUNITY

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

(2015) Jan P. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

Circulating Follicular Helper-Like T Cells in Systemic Lupus Erythematosus: Association With Disease Activity

(2015) Jin-Young Choi et al.   Arthritis & Rheumatology

Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β2-Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti-Domain 1 to Anti-Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome

(2015) Laura Andreoli et al.   Arthritis & Rheumatology

MicroRNAs in lupus

(2014) Hong Zan et al.   AUTOIMMUNITY

Regulatory T cells in systemic lupus erythematosus

(2014) Kim Ohl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

(2014) Michele Proietti et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers

(2014) Saya Moriyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell-MHC Class II and Itk Regulate Functional Development of Regulatory Innate Memory CD4+ T Cells in Bone Marrow Transplantation

(2014) W. Huang et al.   JOURNAL OF IMMUNOLOGY

Fibrosis biomarkers in isolated Raynaud's phenomenon: too little, too soon?

(2013) Francesca Ingegnoli et al.   ANNALS OF THE RHEUMATIC DISEASES

Dual Gating Mechanism and Function of P2X7 Receptor Channels

(2013) Anmar Khadra et al.   BIOPHYSICAL JOURNAL

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Maintenance of Anti-Sm/RNP Autoantibody Production by Plasma Cells Residing in Ectopic Lymphoid Tissue and Bone Marrow Memory B Cells

(2013) J. S. Weinstein et al.   JOURNAL OF IMMUNOLOGY

IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells

(2013) Y. Ding et al.   JOURNAL OF IMMUNOLOGY

Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population

(2013) Gui-Mei Chen et al.   MUTAGENESIS

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

T Follicular Helper Cells Mediate Expansion of Regulatory B Cells via IL-21 in Lupus-Prone MRL/lpr Mice

(2013) Xue Yang et al.   PLoS One

Circulating TFH Subset Distribution Is Strongly Affected in Lupus Patients with an Active Disease

(2013) Carole Le Coz et al.   PLoS One

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

(2013) M. Vono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220+ Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice

(2012) Sylvain M. Le Gall et al.   PLoS One

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

(2011) Helen M. McGuire et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

(2010) Di Yu et al.   Cellular & Molecular Immunology

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Expression and function of the P2X7 purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

(2010) Liliana Portales-Cervantes et al.   HUMAN IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development

(2010) A. C. Poholek et al.   JOURNAL OF IMMUNOLOGY

Antiphospholipid syndrome

(2010) Guillermo Ruiz-Irastorza et al.   LANCET

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

B Cell Proliferation, Somatic Hypermutation, Class Switch Recombination, and Autoantibody Production in Ectopic Lymphoid Tissue in Murine Lupus

(2009) D. C. Nacionales et al.   JOURNAL OF IMMUNOLOGY

ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus

(2009) J. M. Odegard et al.   JOURNAL OF IMMUNOLOGY

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons

(2009) Westley H. Reeves et al.   TRENDS IN IMMUNOLOGY

T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis

(2008) Robert A. Cohen et al.   CLINICAL IMMUNOLOGY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE