The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

Broadly Neutralizing Antiviral Antibodies

(2013) Davide Corti et al.   Annual Review of Immunology

Toward a Universal Influenza Virus Vaccine: Prospects and Challenges

(2013) Natalie Pica et al.   Annual Review of Medicine

Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies

(2013) S. Jegaskanda et al.   JOURNAL OF IMMUNOLOGY

Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

(2013) Jessica A. Belser et al.   NATURE

Biological features of novel avian influenza A (H7N9) virus

(2013) Jianfang Zhou et al.   NATURE

Characterization of H7N9 influenza A viruses isolated from humans

(2013) Tokiko Watanabe et al.   NATURE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Mammalian-Transmissible H5N1 Influenza: Facts and Perspective

(2012) M. T. Osterholm et al.   mBio

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

AID Activity in B Cells Strongly Correlates with Polyclonal Antibody Affinity Maturation in-vivo Following Pandemic 2009-H1N1 Vaccination in Humans

(2012) Surender Khurana et al.   PLoS Pathogens

Akt and mTOR in B Cell Activation and Differentiation

(2012) Jose J. Limon et al.   Frontiers in Immunology

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

(2011) Y Wang et al.   BRITISH JOURNAL OF CANCER

Consequences of suboptimal priming are apparent for low-avidity T-cell responses

(2011) Vanessa Venturi et al.   IMMUNOLOGY AND CELL BIOLOGY

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

(2010) Davide Corti et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective Memory Responses Are Modulated by Priming Events prior to Challenge

(2009) J. A. Rutigliano et al.   JOURNAL OF VIROLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A multi-valent vaccine approach that elicits broad immunity within an influenza subtype

(2009) Victor C. Huber et al.   VACCINE

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One