Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy

(2019) Tomokazu Murakawa et al.   Cell Reports

Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

(2019) Youngjin Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells

(2019) Chia-Yuan Lin et al.   FOOD AND CHEMICAL TOXICOLOGY

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

(2018) Carlos Fernandes et al.   BIOCONJUGATE CHEMISTRY

Phytochemicals as potent modulators of autophagy for cancer therapy

(2018) Mohammad Amin Moosavi et al.   CANCER LETTERS

The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore

(2018) Christopher P. Baines et al.   CELL CALCIUM

Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer

(2018) Jing Xue et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

(2018) José Teixeira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Current perspective of mitochondrial biology in Parkinson's disease

(2018) Navneet Ammal Kaidery et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial permeability transition pore: Back to the drawing board

(2018) Christos Chinopoulos   NEUROCHEMISTRY INTERNATIONAL

Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

(2018) Marianna Holczer et al.   Oxidative Medicine and Cellular Longevity

Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

(2018) Joaquín G. Cordero et al.   Oxidative Medicine and Cellular Longevity

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers

(2018) Elena Alberdi et al.   Oxidative Medicine and Cellular Longevity

EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K/AKT pathway

(2018) Ke-Wang Luo et al.   Oncotarget

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease

(2018) Sandra Franco-Iborra et al.   Frontiers in Neuroscience

Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents

(2018) Andrea Mattarei et al.   Frontiers in Oncology

Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

(2018) Tanila Wood dos Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

(2018) Elena Radi et al.   JOURNAL OF ALZHEIMERS DISEASE

The natural phenolic compounds as modulators of NADPH oxidases in hypertension

(2018) Mozhdeh Yousefian et al.   PHYTOMEDICINE

Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress

(2018) Neelam Malik et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 β pathway

(2018) Mengyuan Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of the BH3 Mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma

(2018) Monica Benvenuto et al.   Frontiers in Pharmacology

Mammalian mitophagy - from in vitro molecules to in vivo models

(2017) Catherine E. Rodger et al.   FEBS Journal

Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

(2017) Yi-Da Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

(2017) José Teixeira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

(2017) Lifa Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin

(2017) Olga V. Tsepaeva et al.   JOURNAL OF NATURAL PRODUCTS

Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

(2017) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2017) Wenyan Sun et al.   NEUROPHARMACOLOGY

Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy

(2017) Thiranut Jaroonwitchawan et al.   NEUROSCIENCE LETTERS

Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review

(2017) Zi-Ying Wang et al.   PHYTOTHERAPY RESEARCH

A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells

(2017) Lin Zhao et al.   Cell Death & Disease

Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a

(2017) Shaofeng Mou et al.   Oncology Letters

Dosis Facit Sanitatem—Concentration-Dependent Effects of Resveratrol on Mitochondria

(2017) Corina Madreiter-Sokolowski et al.   Nutrients

Mitochondria Dysfunction and Neurodegenerative Disorders: Cause or Consequence

(2017) Vanessa A. Morais et al.   JOURNAL OF ALZHEIMERS DISEASE

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Polyphenols journey through blood-brain barrier towards neuronal protection

(2017) I. Figueira et al.   Scientific Reports

Dietary flavonoid intake and risk of incident depression in midlife and older women

(2016) Shun-Chiao Chang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

(2016) Fei Li et al.   BIOCHEMISTRY

Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease

(2016) Qi Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways

(2016) Cristina Parrado-Fernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

(2016) Wanli Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection

(2016) Daniel A. East et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission

(2016) Haili Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Human Monoamine Oxidase: Biological and Molecular Modeling Studies on Selected Natural Flavonoids

(2016) Simone Carradori et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rasagiline prevents cyclosporine A-sensitive superoxide flashes induced by PK11195, the initial signal of mitochondrial membrane permeabilization and apoptosis

(2016) Yuqiu Wu et al.   JOURNAL OF NEURAL TRANSMISSION

Phytochemicals prevent mitochondrial membrane permeabilization and protect SH-SY5Y cells against apoptosis induced by PK11195, a ligand for outer membrane translocator protein

(2016) Yuqiu Wu et al.   JOURNAL OF NEURAL TRANSMISSION

Resveratrol induces intracellular Ca2+ rise via T-type Ca2+ channels in a mesothelioma cell line

(2016) Carla Marchetti et al.   LIFE SCIENCES

Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells

(2016) Akash Sabarwal et al.   MOLECULAR CARCINOGENESIS

Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

(2016) V. Palomera-Avalos et al.   MOLECULAR NEUROBIOLOGY

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

MiR-144-3p and Its Target Gene β-Amyloid Precursor Protein Regulate 1-Methyl-4-Phenyl-1,2-3,6-Tetrahydropyridine-Induced Mitochondrial Dysfunction

(2016) Kuo Li et al.   MOLECULES AND CELLS

Neurodegenerative diseases: From available treatments to prospective herbal therapy

(2016) Isha Solanki et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases

(2016) Zhong-Wei Zhang et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

(2016) Kaige Peng et al.   Oxidative Medicine and Cellular Longevity

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF–κB, uPA activator and MMP9

(2016) Weihua Tong et al.   Oncology Letters

Natural Polyphenols for Prevention and Treatment of Cancer

(2016) Yue Zhou et al.   Nutrients

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

(2015) Arjun Thapa et al.   ACS Chemical Neuroscience

Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro

(2015) Ke Wang et al.   ANTI-CANCER DRUGS

Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay

(2015) Eirini Lionaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin

(2015) Debanjan Tewari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase

(2015) Idalet Engelbrecht et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyphenols as mitochondria-targeted anticancer drugs

(2015) Sylwia Gorlach et al.   CANCER LETTERS

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics

(2015) Hao Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Natural Compounds Modulating Mitochondrial Functions

(2015) Lara Gibellini et al.   Evidence-based Complementary and Alternative Medicine

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

(2015) Francesca Pistollato et al.   FOOD AND CHEMICAL TOXICOLOGY

Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I

(2015) Bo Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy

(2015) Angela Smilansky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Ca2+ Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells

(2015) Hong-Tai Chang et al.   JOURNAL OF NATURAL PRODUCTS

Rasagiline and selegiline suppress calcium efflux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apoptotic function for neuroprotection

(2015) Yuqiu Wu et al.   JOURNAL OF NEURAL TRANSMISSION

Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease

(2015) Hong Lian et al.   JOURNAL OF NEUROCHEMISTRY

Effects of pterostilbene and resveratrol on brain and behavior

(2015) Shibu M. Poulose et al.   NEUROCHEMISTRY INTERNATIONAL

Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

(2015) M.D. Pandareesh et al.   NEUROCHEMISTRY INTERNATIONAL

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

The involvement of mitochondrial apoptotic pathway in eugenol-induced cell death in human glioblastoma cells

(2015) Wei-Zhe Liang et al.   TOXICOLOGY LETTERS

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis

(2015) Vishnu Nayak Badavath et al.   ACS Medicinal Chemistry Letters

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells

(2015) Ju-Hee Lee et al.   Oncotarget

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

(2015) Naïg Gueguen et al.   PLoS One

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

(2014) Cristian Sandoval-Acuña et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System

(2014) Patricia Campos-Bedolla et al.   ARCHIVES OF MEDICAL RESEARCH

Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening

(2014) Ying Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase

(2014) Nicola Sassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

α-Synuclein amino terminus regulates mitochondrial membrane permeability

(2014) Jiamei Shen et al.   BRAIN RESEARCH

The mechanism of honokiol-induced intracellular Ca2+ rises and apoptosis in human glioblastoma cells

(2014) Wei-Zhe Liang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson’s disease mice

(2014) Richard L. Jayaraj et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease

(2014) Xiaoming Qiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

(2014) Pramod Aryal et al.   FEBS Journal

The effects of bioactive compounds from plant foods on mitochondrial function: A focus on apoptotic mechanisms

(2014) Tamara Y. Forbes-Hernández et al.   FOOD AND CHEMICAL TOXICOLOGY

Flavonoids in modulation of cell survival signalling pathways

(2014) Mohammad Lukman Mansuri et al.   Genes and Nutrition

Pro-oxidative and Antioxidative Controls and Signaling Modification of Polyphenolic Phytochemicals: Contribution to Health Promotion and Disease Prevention?

(2014) Kai On Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protein Kinase C Epsilon Regulates Mitochondrial Pools of Nampt and NAD Following Resveratrol and Ischemic Preconditioning in the Rat Cortex

(2014) Kahlilia C Morris-Blanco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bioactive lignans from sesame (Sesamum indicum L.): evaluation of their antioxidant and antibacterial effects for food applications

(2014) C. Mahendra Kumar et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells

(2014) Hadi Ghaffari et al.   LIFE SCIENCES

Natural polyphenols binding to amyloid: A broad class of compounds to treat different human amyloid diseases

(2014) Viviane L. Ndam Ngoungoure et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN

(2014) Somak Das et al.   Oxidative Medicine and Cellular Longevity

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Hydrogen peroxide sensing, signaling and regulation of transcription factors

(2014) H. Susana Marinho et al.   Redox Biology

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols

(2013) Angelique Camilleri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells

(2013) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

(2013) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol decreases breast cancer cell viability and glucose metabolism by inhibiting 6-phosphofructo-1-kinase

(2013) Lilian S. Gomez et al.   BIOCHIMIE

Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms

(2013) Makoto Naoi et al.   Expert Review of Neurotherapeutics

Quercetin Induces Apoptosis via the Mitochondrial Pathway in KB and KBv200 Cells

(2013) Jian-ye Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulation of protein quality control systems by food phytochemicals

(2013) Akira Murakami   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria

(2013) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1  Activation

(2013) K.-H. Jung et al.   JOURNAL OF NUCLEAR MEDICINE

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Protective Effects of Hesperidin Against Amyloid-β (Aβ) Induced Neurotoxicity Through the Voltage Dependent Anion Channel 1 (VDAC1)-Mediated Mitochondrial Apoptotic Pathway in PC12 Cells

(2013) Dong-Mei Wang et al.   NEUROCHEMICAL RESEARCH

Apigenin Sensitizes Prostate Cancer Cells to Apo2L/TRAIL by Targeting Adenine Nucleotide Translocase-2

(2013) Masakatsu Oishi et al.   PLoS One

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

(2012) Michael T. Lin et al.   ANNALS OF NEUROLOGY

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels

(2012) Michael S. Lustgarten et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mitochondrial permeability transition pore (PTP) — An example of multiple molecular exaptation?

(2012) Angelo Vianello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Classification of mitocans, anti-cancer drugs acting on mitochondria

(2012) Jiri Neuzil et al.   MITOCHONDRION

Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-β and α-Synuclein Fibrils

(2011) Gerlinde Grelle et al.   BIOCHEMISTRY

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astaxanthin Induces Mitochondria-Mediated Apoptosis in Rat Hepatocellular Carcinoma CBRH-7919 Cells

(2011) Xiao-dong Song et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds

(2011) Nanako Hamada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Analysis of the Mechanism of Inhibition of Human Matrix Metalloproteinase 7 (MMP-7) Activity by Green Tea Catechins

(2011) Tomoko MIYAKE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease

(2011) Annadurai Anandhan et al.   BRAIN RESEARCH

Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells

(2011) Teresa L. Serafim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

(2011) Pam R. Taub et al.   CTS-Clinical and Translational Science

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

(2011) Mario Caruana et al.   FEBS LETTERS

Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells

(2011) Mauhamad Baarine et al.   Genes and Nutrition

Sesamolinol Glucoside, Disaminyl Ether, and Other Lignans from Sesame Seeds

(2011) Raphael Grougnet et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress

(2011) Natalie Kelsey et al.   NUTRITIONAL NEUROSCIENCE

Intracellular ROS Protection Efficiency and Free Radical-Scavenging Activity of Curcumin

(2011) Abolfazl Barzegar et al.   PLoS One

Mitochondrial Approaches for Neuroprotection

(2010) Rajnish K. Chaturvedi et al.   Annals of the New York Academy of Sciences

Curcumin induced HepG2 cell apoptosis-associated mitochondrial membrane potential and intracellular free Ca2+ concentration

(2010) Mu Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D-QSAR studies on caspase-mediated apoptosis activity of phenolic analogues

(2010) Yuanqiang Wang et al.   JOURNAL OF MOLECULAR MODELING

Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis

(2010) DAVID C. NIEMAN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols

(2009) Umberto De Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons

(2009) Julie Bournival et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

(2009) Makoto Naoi et al.   JOURNAL OF NEURAL TRANSMISSION

Biapigenin Modulates the Activity of the Adenine Nucleotide Translocator in Isolated Rat Brain Mitochondria

(2009) Bruno A. Silva et al.   NEUROTOXICITY RESEARCH

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols

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