Review
Nutrition & Dietetics
Gaia Gherardi, Giovanni Corbioli, Filippo Ruzza, Rosario Rizzuto
Summary: Mitochondria play crucial roles in maintaining cellular homeostasis, regulating energy metabolism, determining cell fate, and serving as intracellular signaling hubs. Mitochondrial deterioration is a critical feature of the aging process, making treatments that improve and sustain mitochondrial functionality potential candidates to counteract age-related mitochondrial dysfunctions.
Article
Chemistry, Medicinal
Mercedes Garcia-Gil, Benedetta Turri, Morena Gabriele, Laura Pucci, Alessandro Agnarelli, Michele Lai, Giulia Freer, Mauro Pistello, Robert Vignali, Renata Batistoni, Silvia Marracci
Summary: The study showed that specific combinations of PRO/GEM can induce cytotoxic effects in pancreatic tumor cells but have cytoprotective or no effects in non-tumor human dermal fibroblasts.
Article
Food Science & Technology
Kaifang Guan, Xiaofen Qi, Haoran Chen, Ying Ma
Summary: Mitochondria-dependent myoblast apoptosis induced by oxidative stress and decrease in protein synthesis plays a crucial role in sarcopenia. Milk fat globule-EGF factor VIII (MFG-E8) can protect against mitochondrial injury and apoptosis through regulation of mitochondrial function and apoptosis-related factors. The findings provide a promising approach for mitigating sarcopenia.
Article
Pharmacology & Pharmacy
Haoran Zhang, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton
Summary: The study reveals the relationship between metabolism and cytotoxic effects of PLB in melanoma, indicating PLB displays stronger cytotoxic effects on A375 cells and triggers cell-specific metabolic changes in accordance with its cytotoxic effects.
Article
Medicine, Research & Experimental
Ruiqi Li, Enhong Li, Gumina Kamili, Songbang Ou, Dongzi Yang
Summary: This study evaluated the effect of resveratrol (RSV) on embryonic development in mice during the process of superovulation. The results showed that RSV treatment significantly improved blastocyst rate in parthenogenetically activated oocytes and naturally fertilized oocytes groups, as well as in aged mice. Additionally, RSV treatment increased mitochondrial function and upregulated mitochondrial biogenesis related genes in cumulus cells, indicating an improvement in oocyte quality for both young and aged mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Liasmine Haine, Celine-Hivda Yegen, Dominique Marchant, Jean-Paul Richalet, Emilie Boncoeur, Nicolas Voituron
Summary: Erythropoietin (Epo) has cell-protective effects beyond its role in red blood cell synthesis, with potential applications in limiting symptoms of acute and chronic lung diseases. Research shows that Epo exhibits protective effects in multiple organs, particularly in the lung.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Rafal Pawel Kampa, Aleksandra Sek, Adam Szewczyk, Piotr Bednarczyk
Summary: The natural flavonoid quercetin acts as a mitoBKCa channel opener, increasing channel open probability and protecting cells from damage. It enhances cellular migration and depolarizes the mitochondrial membrane, while also increasing gene expression and protein levels of mitoBKCa 133 regulatory subunit. The cytoprotective effects suggest the involvement of BKCa channel activation, providing a new mitochondrial pathway beneficial for vascular endothelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Geriatrics & Gerontology
Joshua Kleine, Urszula Hohmann, Tim Hohmann, Chalid Ghadban, Miriam Schmidt, Sebastian Laabs, Beat Alessandri, Faramarz Dehghani
Summary: Acute lesions of the central nervous system often result in permanent limiting deficits. In addition to the initial damage, neuroinflammation also contributes to further damage. Mycophenolate mofetil (MMF) has been shown to modulate the inflammatory response and promote neuronal survival when applied in specific time windows after neuronal injury. This study evaluates the brain cytoprotective effects of MMF and the role of microglia and IMPDH2 protein expression in an in vitro model of excitotoxic brain injury.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chang Ho Lee, Kyung Woon Kim, So Min Lee, So Young Kim
Summary: Low-dose resveratrol has partial otoprotective effects on cisplatin ototoxicity, which may be mediated through anti-oxidative and anti-inflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sonia Mendes da Silva Navarro, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira
Summary: Pretreatment with sesamol (SES) can prevent mitochondrial collapse induced by hydrogen peroxide (H2O2) by reducing the generation of reactive oxygen species (ROS) and protecting mitochondrial function. This protective effect may be achieved through downregulation of pro-inflammatory cytokines and inhibition of NF-kappa B activity. The protection conferred by SES depends on the involvement of the Nrf2 transcription factor.
METABOLIC BRAIN DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Anna Staskiewicz, Erica Wong, Michael Tucker, Riya Farhin, Jonathan Park, Rana Saade, Tina Alkhazali, Tu Dang, Xinyu Wang
Summary: Multiple myeloma (MM) is a cancer characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ) is a common treatment for MM, but can be toxic at high doses. Resveratrol (RES), a compound found in grapes, inhibits MM cell growth. This study identified a synergistic combination of BTZ and a RES derivative that decreased MM cell viability by inducing apoptosis and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Antoni Wrzosek, Shur Galecka, Monika Zochowska, Anna Olszewska, Bogusz Kulawiak
Summary: Mitochondrial potassium channels play a crucial role in regulating mitochondrial function and cell survival, with potential applications in ischemia/reperfusion injury and cancer treatment.
Review
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Sylwia Borska
Summary: Cancer diseases pose a major challenge in clinical medicine globally, with drug resistance being a significant issue. Natural compounds, particularly polyphenols, are believed to have pleiotropic effects on cells and toxic effects on cancer cells, showing promise as a new approach to cancer treatment. Studies on the effectiveness of resveratrol in treating cancer, including reversing multidrug resistance, are ongoing and may provide valuable insights for future in vivo and clinical studies.
Review
Food Science & Technology
Barry Halliwell, Richard M. Y. Tang, Irwin K. Cheah
Summary: This article summarizes the current understanding of the biological roles of ergothioneine (ET), a compound derived from the diet. ET is important to humans because it is efficiently absorbed from the diet and retained within the body for a long period of time. The potential functions of ET in vivo are explored, with a focus on its antioxidant properties. However, the evidence supporting ET's role as an antioxidant in vivo is weak, similar to other compounds like vitamin C and flavonoids. In contrast, α-tocopherol has demonstrated antioxidant effects in humans.
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Hamdy A. A. Aly
Summary: Diabetes induces testicular damage, partially through inducing mitochondria-mediated apoptosis and oxidative stress. Resveratrol administration improves diabetes-induced testicular dysfunction through its antioxidant and anti-apoptotic effects.
Article
Biology
Zhanat Koshenov, Furkan E. Oflaz, Martin Hirtl, Benjamin Gottschalk, Rene Rost, Roland Malli, Wolfgang F. Graier
Summary: The study investigates the regulation of basal mitochondrial bioenergetics and reveals that Ca2+ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The researchers identify citrin as a primary regulator of this process and show that manipulation of Ca2+ dynamics can reprogram cellular and mitochondrial metabolism.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ines Tawfik, Benjamin Gottschalk, Angelo Jarc, Doruntina Bresilla, Rene Rost, Barbara Obermayer-Pietsch, Wolfgang F. Graier, Corina T. Madreiter-Sokolowski
Summary: Thyroid hormones regulate mitochondrial Ca2+ uptake, leading to increased energy metabolism and reactive oxygen species production.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Madeleine Goeritzer, Stefanie Schlager, Katharina B. Kuentzel, Nemanja Vujic, Melanie Korbelius, Silvia Rainer, Dagmar Kolb, Marion Mussbacher, Manuel Salzmann, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, Corina T. Madreiter-Sokolowski, Sandra Blass, Thomas O. Eichmann, Wolfgang F. Graier, Dagmar Kratky
Summary: Loss of ATGL in platelets is associated with an anti-thrombogenic phenotype without pathological bleeding and platelet activation.
Article
Cell Biology
Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Zhanat Koshenov, Wolfgang F. Graier, Nemanja Vujic, Dagmar Kratky, Richard Rivera, Jerold Chun, Wolfgang Sattler
Summary: Systemic inflammation induces increased synthesis of LPA(5), which activates microglia and promotes neuroinflammation.
Article
Biochemistry & Molecular Biology
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Rene Rost, Roland Malli, Wolfgang F. Graier
Summary: The study revealed that S1R plays an important role in cancer energy metabolism. Activation of S1R increases mitochondrial bioenergetics while reducing reliance on aerobic glycolysis in cancer cells. S1R antagonist, on the other hand, increases aerobic glycolysis in S1R expressing cancer cell line.
Article
Biochemistry & Molecular Biology
Christiane Klec, Erik Knutsen, Daniela Schwarzenbacher, Katharina Jonas, Barbara Pasculli, Ellen Heitzer, Beate Rinner, Katarina Krajina, Felix Prinz, Benjamin Gottschalk, Peter Ulz, Alexander Deutsch, Andreas Prokesch, Stephan W. Jahn, S. Mohammad Lellahi, Maria Perander, Raffaela Barbano, Wolfgang F. Graier, Paola Parrella, George Adrian Calin, Martin Pichler
Summary: The RNA-binding protein ALYREF plays a significant role in breast carcinogenesis by regulating the two isoforms of NEAT1, which in turn affects cellular growth, apoptosis, and mitochondrial energy metabolism. This study provides novel insights into the molecular mechanisms underlying breast cancer and has important implications for its treatment and prevention.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Transplantation
Andras T. Deak, Katarina Belic, Anna-Maria Meissl, Katharina Artinger, Kathrin Eller, Bernd Rechberger, Tobias Niedrist, Wolfgang F. Graier, Roland Malli, Helmut Bischof, Sandra Burgstaller, Sandra Blass, Alexander Avian, Alexander R. Rosenkranz, Alexander H. Kirsch
Summary: This study assessed the performance of genetically encoded potassium-ion indicators (GEPIIs) in measuring salivary potassium concentration and found that salivary potassium levels exhibited similar kinetics to plasma potassium levels. However, further research is needed to determine if saliva could be a suitable sample type for monitoring plasma potassium levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Sudhir Pandey, Corina T. Madreiter-Sokolowski, Supachoke Mangmool, Warisara Parichatikanond
Summary: This study found that under high glucose conditions, the ET-1 signaling pathway leads to mitochondrial dysfunction, with the involvement of the mTOR pathway. Inhibiting either the ET-1 signaling pathway or the mTOR pathway can alleviate this dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Doruntina Bresilla, Hansjoerg Habisch, Iva Pritisanac, Kim Zarse, Warisara Parichatikanond, Michael Ristow, Tobias Madl, Corina T. Madreiter-Sokolowski
Summary: C57BL/6NRj mice are an ideal model for studying cellular alterations in metabolism, and age-related metabolic alterations occur at an early stage and may be associated with a metabolic switch. There are sex-specific differences in the metabolite signatures of different tissues, and metabolomic features are highly dependent on the genetic background of mouse strains.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Furkan E. Oflaz, Zhanat Koshenov, Martin Hirtl, Olaf A. Bachkoenig, Wolfgang F. Graier, Benjamin Gottschalk
Summary: Mitochondrial uncoupling proteins UCP1 and UCP2 have different molecular mechanisms for executing their mitochondria uncoupling function, with UCP1 dissipating the proton motive force and UCP2 modulating the permeability of the cristae junction. This mini-review discusses the molecular mechanisms of UCP1 in brown adipose tissue and UCP2 in aged and cancer non-excitable cells, and the synergistic effects of both UCPs with the mitochondrial Ca2+ uptake machinery.
Article
Genetics & Heredity
Lukas Kaufmann, Johannes Pilic, Lisa Auinger, Anna-Lena Mayer, Jasmin Blatterer, Johann Semmler-Bruckner, Safdar Abbas, Khurram Rehman, Muhammad Ayaz, Wolfgang F. Graier, Roland Malli, Erwin Petek, Klaus Wagner, Ali Al Kaissi, Muzammil Ahmad Khan, Christian Windpassinger
Summary: Restrictive dermopathy (RD) is a lethal condition caused by loss-of-function mutations in ZMPSTE24, while mutations preserving residual enzymatic activity lead to mandibuloacral dysplasia with type B lipodystrophy (MADB) phenotype. A new homozygous loss-of-function mutation in ZMPSTE24 was identified in two consanguineous Pakistani families with MADB. Functional analysis revealed that alternative translation initiation sites were utilized, preventing complete loss of protein function and explaining the relatively mild phenotype in affected patients. Our findings suggest considering the creation of new potential start codons in other disease-associated genes with N-terminal mutations.
Article
Biochemistry & Molecular Biology
Madeleine Goeritzer, Katharina B. Kuentzel, Sarah Beck, Melanie Korbelius, Silvia Rainer, Ivan Bradic, Dagmar Kolb, Marion Mussbacher, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, Rene Rost, Benjamin Gottschalk, Thomas O. Eichmann, Thomas Zuellig, Wolfgang F. Graier, Nemanja Vujic, Dagmar Kratky
Summary: Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) and plays a role in platelet function. MGL deficiency leads to decreased platelet aggregation and impaired response to collagen activation, resulting in reduced thrombus formation and prolonged bleeding time. Genetic deletion of MGL is associated with altered thrombogenesis in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Benjamin Gottschalk, Roland Malli, Wolfgang F. Graier
Summary: Changes in mitochondrial ultrastructure and dynamics, including cytochrome c release, membrane potential rearrangement, and mitochondrial Ca2+ uptake dynamics, are observed in MICU1(-/-) cells due to its sensitivity to Ca2+ and its binding to Mic60 and CHCHD2. MICU1 is not only an interaction partner and regulator of the MCU complex, but also plays a crucial role in determining mitochondrial ultrastructure and initiating apoptosis.
Article
Chemistry, Multidisciplinary
Zuzana Klepcova, Ivana Spakova, Corina T. T. Madreiter-Sokolowski, Wolfgang Graier, Katarina Kalinova, Erika Samolova, Romana Smolkova, Lukas Smolko, Miroslava Rabajdova
Summary: Two novel Mn(II) complexes with fenamic acid and flufenamic acid as ligands and neocuproine as a supporting ligand were synthesized and characterized. The complexes exhibit moderate radical scavenging activity and cytotoxic effects on selected cell lines, with the flufenamic acid complex being able to induce apoptosis. Both complexes target inflammatory processes on a cellular level.
NEW JOURNAL OF CHEMISTRY
(2023)
