Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Zijuan Zhang, Hai Li, Yunfang Su, Jinlian Ma, Ye Yuan, Ziyang Yu, Ming Shi, Simai Shao, Zhenqiang Zhang, Christian Holscher
Summary: Research demonstrates that the CCK analogue has neuroprotective effects and improves locomotor function in an acute PD mouse model. It acts by restoring dopaminergic neuron count and synapse number, reducing neuroinflammation and autophagy impairment, and protecting against mitochondrial and ER damage.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Abdolvahed Narmashiri, Mojtaba Abbaszadeh, Ali Ghazizadeh
Summary: This article provides a comprehensive review and meta-analysis on the effects of MPTP on memory and motor functions in Parkinson's disease. The results show that MPTP not only significantly affects motor functions, but also various mnemonic processes. However, no systematic relationship between the MPTP injection protocol parameters and the extent of induced PD symptoms was found.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Yuxiao Yao, Diego Baronio, Yu-Chia Chen, Congyu Jin, Pertti Panula
Summary: This study found that the absence of the hrh1 gene in zebrafish leads to deficits in the dopaminergic and hypocretin systems during early development, but these deficits are compensated for in adulthood. However, adult fish exhibit impaired sociability and anxious-like behavior, along with downregulation of choline O-acetyltransferase and LIM homeodomain transcription factor Islet1.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Neurosciences
Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A. Mennigen, Michael G. Jonz
Summary: Dopamine plays a role in oxygen sensing and autonomous ventilation control in aquatic vertebrates. This study provides evidence that dopamine is synthesized and stored by sensory nerve terminals that innervate chemoreceptive neuroepithelial cells (NECs) in the gills. The D2 receptors on NECs act as a feedback mechanism to attenuate the chemoreceptor response to hypoxia. These findings suggest a fundamental, modulatory role for dopamine in oxygen sensing early in vertebrate evolution.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Bhupesh Vaidya, Pankaj Gupta, Joydev K. Laha, Ipsita Roy, Shyam Sunder Sharma
Summary: This study found that blocking and silencing TRPC5 channels can improve behavioral deficits and molecular changes in Parkinson's disease models. It was also observed that overexpression of TRPC5 channels is associated with the occurrence of Parkinson's disease, providing a new therapeutic approach for the treatment of neurodegenerative diseases and Parkinson's disease.
Article
Neurosciences
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Summary: The study found that DA neurons expressing VGLUT2 in the VTA/SNc exhibit higher resilience to rotenone-induced neurodegeneration, with an increase in VGLUT2 expression in response to rotenone. Dopaminergic terminals with VGLUT2 expression show greater protection throughout the striatum.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Rodent models of Parkinson's disease are created using transgenic methods like mutant synuclein expression, PD gene deletions, MPTP or rotenone injections, or seeding with synuclein fibrils. These models exhibit histopathologic features of PD, such as Lewi bodies, but do not completely mimic the predominant loss of dopaminergic neurons. A study introducing transgenic diphtheria toxin receptor to mice showed partial ablation of neurons without PD-like behavioral correlates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Summary: This study found that the TH-DA pathway plays a critical role in the pathogenesis of Parkinson's disease. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and the balance between them affects the survival of DA neurons. Mutations in LRRK2 or PINK1 can disrupt this balance, leading to the demise of DA neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Sage S. Frehner, Kip T. Dooley, Michelle C. Palumbo, Aaron L. Smith, Mark M. Goodman, Karen L. Bales, Sara M. Freeman
Summary: This study found significantly lower levels of OXTR in females with autism compared to other groups. There were no differences in mRNA levels for either gene across the four groups. These results suggest that dysregulation in OXTR protein translation or increased OXTR internalization/recycling may contribute to the differences in social symptoms seen in females with autism.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Frederick Wasinski, Fernanda M. Chaves, Joao A. B. Pedroso, Naira S. Mansano, Joao Paulo Camporez, Daniela O. Gusmao, Edward O. List, John J. Kopchick, Renata Frazao, Raphael E. Szawka, Jose Donato
Summary: Deletion of GHR in DAT- or TH-expressing cells does not affect various physiological aspects in male and female mice, but impairs restraint stress-induced prolactin release in male mice, suggesting sex differences in the regulation of GHR signaling on prolactin secretion. The mechanism behind this regulation requires further investigation.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anastasiia Kotliarova, Alexandra V. V. Podturkina, Alla V. V. Pavlova, Daria S. S. Gorina, Anastasiya V. V. Lastovka, Oleg V. V. Ardashov, Artem D. D. Rogachev, Arseniy E. E. Izyurov, Alla B. B. Arefieva, Alexander V. V. Kulikov, Tatyana G. G. Tolstikova, Konstantin P. P. Volcho, Nariman F. F. Salakhutdinov, Yulia Sidorova
Summary: This study evaluated the neuroprotective effects of a novel compound, PA96, on dopamine neurons in Parkinson's disease. The results showed that PA96 supported the survival of naive and MPP+-challenged dopamine neurons in vitro and in vivo. PA96 also alleviated motor deficits in PD models and exhibited appropriate properties for drug development.
Article
Neurosciences
Mohamad Ayajuddin, Rahul Chaurasia, Abhik Das, Priyanka Modi, Limamanen Phom, Zevelou Koza, Sarat Chandra Yenisetti
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. Using a fly model, our laboratory has shown that there is a reduction in fluorescence intensity of secondary antibodies targeting tyrosine hydroxylase, indicating a decrease in dopamine synthesis and dysfunction of dopaminergic neurons. This quantification method of fluorescence intensity can be a sensitive and cost-effective approach for studying neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Liu
Summary: Liver failure is associated with increased levels of dopamine in the brain, which can lead to psychiatric alterations. This study investigated the relationship between dopamine levels and mental abnormalities using BDL rats and SH-SY5Y cells, and explored the mechanism by which liver failure increases dopamine levels.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Saravana Babu Chidambaram, Abid Bhat, Bipul Ray, Mani Sugumar, Serva Peddha Muthukumar, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Gilles J. Guillemin, Meena Kishore Sakharkar
NUTRITIONAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Samir Al-Adawi, Aziz Al-Naamani, Sanjay Jaju, Yahya M. Al-Farsi, Atsu S. S. Dorvlo, Ali Al-Maashani, Sara S. H. Al-Adawi, Ahmed A. Moustafa, Nasser Al-Sibani, Musthafa M. Essa, David T. Burke, M. Walid Qoronfleh
Article
Oncology
Meena Kishore Sakharkar, Sarinder Kaur Dhillon, Saravana Babu Chidambaram, Musthafa Mohamed Essa, Jian Yang
Review
Geriatrics & Gerontology
Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Muhammed Bishir, Srinivasa Rao Bolla, Jian Yang, Musthafa Mohamed Essa, Saravana Babu Chidambaram, Gilles J. Guillemin, Meena Kishore Sakharkar
Review
Biochemistry & Molecular Biology
Sreeja Lakshmi, Musthafa Mohamed Essa, Richard E. Hartman, Gilles J. Guillemin, Sureshkumar Sivan, Preetham Elumalai
NEUROCHEMICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Abid Bhat, Bipul Ray, Arehally Marappa Mahalakshmi, Sunanda Tuladhar, D. N. Nandakumar, Malathi Srinivasan, Musthafa Mohamed Essa, Saravana Babu Chidambaram, Gilles J. Guillemin, Meena Kishore Sakharkar
PHARMACOLOGICAL RESEARCH
(2020)
Review
Biotechnology & Applied Microbiology
Muhammed Bishir, Abid Bhat, Musthafa Mohamed Essa, Okobi Ekpo, Amadi O. Ihunwo, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Sulie Chang, Saravana Babu Chidambaram, Meena Kishore Sakharkar, Gilles J. Guillemin, M. Walid Qoronfleh, David J. Ojcius
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biotechnology & Applied Microbiology
Sivakumar Lingappa, Muthugounder Subramanian Shivakumar, Thamilarasan Manivasagam, Somasundaram Thirugnanasambandan Somasundaram, Palaniappan Seedevi
Summary: Epalrestat (EPS) is an aldose reductase inhibitor that penetrates the blood-brain barrier and is used in the treatment of diabetic neuropathy. It has been found to reduce neurodegeneration by inhibiting ROS-induced oxidative damage and has shown potential in regulating Alzheimer's disease pathology through GSK3 beta and tau protein phosphorylation. An optimal concentration of EPS therapy may decrease AD progression by reducing tau phosphorylation levels.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Integrative & Complementary Medicine
B. S. Reshma, Thabitha Aavula, Vignesh Narasimman, Saravanan Ramachandran, Musthafa Mohamed Essa, M. Walid Qoronfleh
Summary: This study demonstrates that agar extracted from L. digitata has antioxidant and antiaging properties, providing protective effects against D-Gal-induced damage in mice.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Engineering, Chemical
Nader I. Al-Dewik, Salma N. Younes, Musthafa Mohamed Essa, Surajit Pathak, M. Walid Qoronfleh
Summary: Translational medicine plays a vital role in improving treatment strategies and patient outcomes, with biomarkers being an important component in clinical applications. However, the clinical validation of biomarkers remains challenging, widening the gap between research and application.
Review
Biochemistry & Molecular Biology
Cassio Luiz Coutinho Almeida-da-Silva, Nallusamy Sivakumar, Homer Asadi, Anna Chang-Chien, M. Walid Qoronfleh, David M. Ojcius, Musthafa Mohamed Essa
Summary: Frankincense oil, derived from Boswellia trees, has been used for the treatment of chronic disease, inflammation, and microbial infection. Recent research has focused on the bioactive components of Boswellia trees and their effects on cancer, microbial infection, and inflammation. There is growing interest in further developing the therapeutic use of natural products like frankincense oil.
Review
Immunology
Areeg M. Dabbish, Nouran Yonis, Mohamed Salama, Musthafa M. Essa, M. Walid Qoronfleh
Summary: The public health crisis of COVID-19 began in January 2020, with the SARS-CoV-2 genome being related to other pathogenic coronaviruses such as SARS-CoV and MERS-CoV. The virus enters host cells through endocytosis, triggering immune responses that fight against the pathogen. While innate immunity secretes proinflammatory cytokines and interferons, adaptive immunity initiates antibody and cellular mediated responses.
EUROPEAN JOURNAL OF INFLAMMATION
(2021)
Review
Neurosciences
Chenthamara Dhrisya, Murugan Prasathkumar, Robert Becky, Salim Anisha, Subramaniam Sadhasivam, Musthafa Mohamed Essa, Saravana Babu Chidambaram, Buthainah Al-Balushi, Gilles J. Guillemin, M. Walid Qoronfleh
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2020)
Correction
Biochemistry & Molecular Biology
Mani Kavitha, Jagatheesan Nataraj, Musthafa Mohammed Essa, Mushtaq A. Memon, Thamilarasan Manivasagam
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Correction
Neurosciences
Sathiya Sekar, Sugumar Mani, Barathidasan Rajamani, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Abid Bhat, Bipul Ray, Musthafa Mohamed Essa, Gilles J. Guillemin, Saravana Babu Chidambaram
NEUROTOXICITY RESEARCH
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
