Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction

(2015) Alessandra Bosutti et al.   Scientific Reports

Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase

(2014) Nicola Sassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria-targeted Resveratrol Derivatives Act as Cytotoxic Pro-oxidants

(2014) Nicola Sassi et al.   CURRENT PHARMACEUTICAL DESIGN

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

(2014) X Zhou et al.   Cell Death & Disease

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

(2013) James A. Birrell et al.   BIOCHEMICAL JOURNAL

Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis

(2013) Chengzhi Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

(2013) Valérie Desquiret-Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

(2013) Lasse Gliemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dual Effects of Resveratrol on Arterial Damage Induced By Insulin Resistance in Aged Mice

(2013) S. Baron et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Ultra high performance liquid chromatography-quadrupole-time of flight analysis for the identification and the determination of resveratrol and its metabolites in mouse plasma

(2012) M.C. Menet et al.   ANALYTICA CHIMICA ACTA

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: Investigation of the role of gender

(2012) Ana C. Moreira et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium

(2012) Beamon Agarwal et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening

(2012) Jean Z. Boyer et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

(2012) Melanie Gertz et al.   PLoS One

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation

(2011) Virginie Guillet et al.   FASEB JOURNAL

A ternary mechanism for NADH oxidation by positively charged electron acceptors, catalyzed at the flavin site in respiratory complex I

(2011) James A. Birrell et al.   FEBS LETTERS

Exposure to resveratrol triggers pharmacological correction of fatty acid utilization in human fatty acid oxidation-deficient fibroblasts

(2011) J. Bastin et al.   HUMAN MOLECULAR GENETICS

Long-Term Supplementation With Resveratrol Alleviates Oxidative Stress but Does Not Attenuate Sarcopenia in Aged Mice

(2011) Janna R. Jackson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver

(2011) Helena Schirmer et al.   MOLECULAR BIOLOGY REPORTS

Tracing the Trail of Protons through Complex I of the Mitochondrial Respiratory Chain

(2011) Arnaud Mourier et al.   PLOS BIOLOGY

Spontaneous mutagenesis in Csb m/m Ogg1 −/− mice is attenuated by dietary resveratrol

(2010) Markus Fusser et al.   CARCINOGENESIS

Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dose response biology: The case of resveratrol

(2010) Edward J Calabrese et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

trans-Resveratrol as A Neuroprotectant

(2010) Ellen L. Robb et al.   MOLECULES

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches

(2009) Candice E. Paulsen et al.   ACS Chemical Biology

Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet

(2009) Mélissa Flamment et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets

(2009) K.K.R. Rocha et al.   FOOD AND CHEMICAL TOXICOLOGY

Mitochondrial alterations in aging rat brain: effective role of (−)-epigallo catechin gallate

(2009) Ravichandran Srividhya et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Development and implementation of standardized respiratory chain spectrophotometric assays for clinical diagnosis

(2009) F. Medja et al.   MITOCHONDRION

Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity

(2009) Virginie Guillet et al.   MITOCHONDRION

Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens

(2009) G.-Y. Tan et al.   POULTRY SCIENCE

Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock

(2009) Zsolt Bikadi et al.   Journal of Cheminformatics

Dietary resveratrol administration increases MnSOD expression and activity in mouse brain

(2008) Ellen L. Robb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The production of reactive oxygen species by complex I

(2008) Judy Hirst et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors

(2008) Alexei P. Kudin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Oxidative Impairment of Mitochondrial Electron Transport Chain Complexes in Rostral Ventrolateral Medulla Contributes to Neurogenic Hypertension

(2008) Samuel H.H. Chan et al.   HYPERTENSION

Brain mitochondrial dysfunction in aging

(2008) Alberto Boveris et al.   IUBMB LIFE

Aggregation State and pKaValues of (E)-Resveratrol As Determined by Fluorescence Spectroscopy and UV−Visible Absorption

(2008) José Manuel López-Nicolás et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity

(2008) Wayne R. Leifert et al.   NUTRITION RESEARCH

Cardioprotective actions of grape polyphenols

(2008) Wayne R. Leifert et al.   NUTRITION RESEARCH