Article
Chemistry, Multidisciplinary
Shiya Chen, Mingjian Chen, Jinfeng Yang, Xianqing Zeng, Yibo Zhou, Sheng Yang, Ronghua Yang, Quan Yuan, Jing Zheng
Summary: Hypoxia and acidic pH are chosen as dual stimuli to fabricate a dual lock-and-key fluorescent nanoprobe for highly specific and precise imaging of tumor cells. This nanoprobe successfully applies in a tumor-bearing mice model, indicating the potential for early diagnosis and assessment of cancer treatment.
Article
Oncology
Gilberto Gastelum, Jeffry Kraut, Mysore Veena, Alisher Baibussinov, Christopher Lamb, Kylee Lyons, Eric Y. Chang, Patrick Frost
Summary: Hypoxia-induced apoptosis of MM cells is correlated with acidic intracellular pH. Targeting intracellular pH may be more effective at treating cancers within a hypoxic TME.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Nathaniel H. Boyd, Anh Nhat Tran, Joshua D. Bernstock, Tina Etminan, Amber B. Jones, G. Yancey Gillespie, Gregory K. Friedman, Anita B. Hjelmeland
Summary: Tumor microenvironments result from cellular alterations in cancer that promote unrestricted growth and angiogenesis, with hypoxia and acidic stress known to modulate therapeutic resistance. Understanding the interplay between tumor microenvironments and glioma stem cells is crucial for developing better treatment options for glioblastoma.
Article
Biotechnology & Applied Microbiology
Qiao Pan, Ruyi Fan, Rui Chen, Jiayi Yuan, Shixuan Chen, Biao Cheng
Summary: The pH value of the wound microenvironment is important for skin wound healing. Low pH is generally favorable for wound regeneration, but alkaline microenvironments may be required for certain healing processes. Growth factors with different isoelectric points can have different effects in different pH wound microenvironments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Oncology
Ana Belen Herrera-Campos, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Monica Fernandez-Cortes, Luis M. Montuenga, F. Javier Oliver, Angel Garcia-Diaz
Summary: The tumor microenvironment (TME) characterized by low oxygen supply (hypoxia) is associated with aggressive cancer phenotypes and poor prognosis. Supplemental oxygen, or hyperoxia, has been shown to improve the efficacy of cancer therapies by reducing tumor hypoxia and promoting antitumor immunity. However, prolonged exposure to high oxygen levels can cause lung injury and inflammation, which may have negative consequences. Further studies are needed to optimize the use of hyperoxia in cancer treatment and prevent its side effects.
Article
Biotechnology & Applied Microbiology
Sevinc Karacam, Sinem Tuncer
Summary: The cell-free supernatant from Streptococcus salivarius M18 was found to effectively inhibit the growth, antibiotic resistance, and biofilm formation of pathogens Pseudomonas aeruginosa and Klebsiella pneumonia, especially under acidic conditions. This supernatant also demonstrated anti-cancer actions on colon cancer cells in pH conditions mimicking the acidity of tumors, particularly when obtained from inulin-incubated S. salivarius M18. These findings suggest the potential of using S. salivarius M18 functional probiotic products to target low pH environments, including the unique acidic microenvironment of tumors.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Chemistry, Physical
Behnaz Ghaemi, Mohammad Javad Hajipour
Summary: This study investigates the biological impacts of different nanoparticles on cancer cells at different pH levels. The researchers found that a slight change in the pH of the cancer cell microenvironment significantly affects the cellular uptake efficacy and toxicity mechanism of the nanoparticles. The nanoparticles exhibited more toxic effects against cancer cells at physiological pH compared to acidic pH, and they also affected different phases of the cell cycle at different pH levels. Additionally, cancer cells expressed higher levels of interleukins involved in cancer cell resistance at acidic pH. The findings highlight the importance of considering the extracellular pH of cancer cells in future cancer nanomedicine research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Xiuhui Shi, Min Wang, Yuqing Zhang, Xingjun Guo, Mingyang Liu, Zhijun Zhou, Yan Zhao, Ruizhi He, Yang Gao, Yuhui Liu, Shutao Pan, Min Zhou, Chunle Zhao, Taoyuan Yin, Xu Li, Hebin Wang, Jingxuan Yang, Feng Zhu, Min Li, Renyi Qin
Summary: High expression levels of alpha-SMA and hypoxia markers are associated with poor prognosis in pancreatic cancer patients. Mechanistically, hypoxia induces HGF expression and secretion in PSC via HIF-1 alpha, which then activates Met and suppresses pancreatic cancer cell sensitivity to EGFR inhibitors. The combination of EGFR inhibitor and Met inhibitor shows promise for pancreatic cancer treatment based on the demonstrated signaling axis between PSC and cancer cells.
Review
Immunology
Irene Garces-Lazaro, Rebecca Kotzur, Adelheid Cerwenka, Ofer Mandelboim
Summary: Environmental conditions greatly shape the phenotype and function of immune cells, including natural killer (NK) cells. The impact of low oxygen concentrations on NK cell reactivity is still not fully understood, making it an emerging field in pathological and physiological immune biology.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Siqi Chen, Yaqing Du, Xin-Yuan Guan, Qian Yan
Summary: Hepatocellular carcinoma (HCC) is a heterogeneous and aggressive liver cancer with limited treatment options. Sorafenib, the standard therapy for advanced HCC, frequently encounters resistance, highlighting the need to uncover underlying mechanisms and develop effective treatments.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Diana Tavares-Valente, Barbara Sousa, Fernando Schmitt, Fatima Baltazar, Odilia Queiros
Summary: The reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism and the generation of an acidic tumor microenvironment, contributing to drug resistance. Inhibiting the expression of pH regulators can reduce cancer cell aggressiveness and increase sensitivity to chemotherapy.
Article
Chemistry, Multidisciplinary
Xin Liu, Ningbing Ye, Chen Xiao, Xiaoxian Wang, Shiyou Li, Yihan Deng, Xiaoquan Yang, Zifu Li, Xiangliang Yang
Summary: This study demonstrated for the first time the successful combination of hyperbaric oxygen (HBO) therapy with commercialized nanomedicines in eliminating cancer stem-like cells (CSCs) in solid tumors, showing efficient anticancer effects in treating tumors such as triple negative breast cancer and pancreatic ductal adenocarcinoma.
Article
Chemistry, Multidisciplinary
Xueqin Yang, Changhuo Xu, Xun Zhang, Pei Li, Feiyi Sun, Xinyue Liu, Xinyuan Wang, Ryan T. K. Kwok, Jinglei Yang, Jacky W. Y. Lam, Yongye Liang, Ben Zhong Tang
Summary: A facile molecular engineering strategy was developed to design photosensitizers (PSs) with aggregation induced emission (AIE) characteristics and responsive properties to the acidic tumor microenvironment (TME). Two near-infrared AIE luminogens called DBP-SPy and DBP-SPh were synthesized, which can form nanoaggregates and show different surface charge conversion properties in response to the pH of the TME. The DBP-SPy nanoaggregates demonstrated efficient photodynamic therapy on cancer cells in vitro and excellent tumor growth inhibition in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Oncology
Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi, Mostafa Manian
Summary: Tumor hypoxia, caused by rapid tumor growth and abnormal blood vessel formation, can activate angiogenesis, increase tumor survival, suppress immunity, and requires management through mechanisms such as altering gene expression. The potential use of cancer stem cells in tumor treatment has been highlighted.
CANCER CELL INTERNATIONAL
(2021)
Article
Nanoscience & Nanotechnology
X. Wan, H. Zhang, Q. Yan, H. Hu, W. Pan, Y. Chai, Y. Gao, N. Li, B. Tang
Summary: This study reported a porphyrin-based three-dimensional covalent organic framework as an enzyme nanoprotector to maintain the activity of catalase under acidic tumor microenvironment. The nanoprotector can efficiently generate reactive oxygen species and realize photodynamic therapy of cancer, greatly enhancing the efficacy of cancer therapy.
MATERIALS TODAY NANO
(2022)
Review
Food Science & Technology
Suhuan Mei, Manivel Perumal, Maurizio Battino, David D. Kitts, Jianbo Xiao, Haile Ma, Xiumin Chen
Summary: Mangiferin has potential applications in nutraceutical and functional food products due to its bioactivities, but its low bioavailability limits its efficacy. This review provides information on food sources, absorption, and metabolism of mangiferin, as well as recent progress in enhancing its bioavailability. The safety and improved bioavailability are key factors for successful use of mangiferin as a dietary supplement or nutraceutical.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pediatrics
Rachele De Giuseppe, Francesca Bergomas, Federica Loperfido, Francesca Giampieri, Giorgia Preatoni, Valeria Calcaterra, Hellas Cena
Summary: This systematic review aims to evaluate the literature regarding the association between overweight/obesity and celiac disease (CD) in school-age children. The results showed that the prevalence of overweight or obesity in school-age children affected by CD ranged between 3.5% and 20%, highlighting that the coexistence of CD with overweight/obesity in children is not uncommon.
Article
Biochemistry & Molecular Biology
Andrea Pirkovic, Aleksandra Vilotic, Suncica Borozan, Mirjana Nacka-Aleksic, Zanka Bojic-Trbojevic, Milica Jovanovic Krivokuca, Maurizio Battino, Francesca Giampieri, Dragana Dekanski
Summary: The bioactive compound oleuropein derived from olives was evaluated for its effects on damage induced by hydrogen peroxide in human trophoblast cells in vitro. The study found that oleuropein had cytoprotective effects by improving antioxidant status, preventing protein and lipid damage, and reducing iNOS levels.
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Francisco J. Orantes, Adelaida Esteban-Munoz, Cristina M. Perez-Oleaga, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Francesca Giampieri, Jose L. Quiles, Tamara Y. Forbes-Hernandez
Summary: This study aims to characterize monofloral avocado honey (AH) and evaluate its phenolic profile and antioxidant capacity. The results show that AH exhibits high antioxidant capacity in vitro and in vivo, which is relevant for the prevention of Alzheimer's disease.
Review
Food Science & Technology
Marco Brusati, Luciana Baroni, Gianluca Rizzo, Francesca Giampieri, Maurizio Battino
Summary: Plant-based milk alternatives can be divided into two main categories: plant-based formulas and plant-based drinks, which differ in production processes and regulation. These products have gained wide acceptance in the international market. The nutritional characteristics of various plant-based milk alternatives differ due to their origin and manufacturing. Plant-based drinks, unlike formulas from plant and cow origin, are nutritionally different from cow's milk and can be consumed by children after using formula. Scientific organizations have expressed conflicting opinions on the use of these products in children's diets, especially in terms of timing, quantities, and type of product. Considering the child's overall diet and health, it is recommended to see these foods not as simple substitutes for cow's milk, but as part of a varied diet, with individual advice for use.
Review
Chemistry, Multidisciplinary
Andrea Beltran-Noboa, Alejandro Jordan-Alvarez, Mabel Guevara-Teran, Blanca Gallo, Luis A. . Berrueta, Francesca Giampieri, Maurizio Battino, Jose M. Alvarez-Suarez, Eduardo Tejera
Summary: Ocimum is the largest genus in the Lamiacea family and includes aromatic plants like basil, which have culinary and medicinal potential. This systematic review examines the chemical composition of nonessential oils in different species of Ocimum. The study reveals a wide variety of compounds, suggesting that this genus could be a valuable source of bioactive compounds. However, there is a significant gap between the number of Ocimum species discovered and the studies that have determined their chemical characterization.
Review
Food Science & Technology
Yu Sun, Arshad Mehmood, Francesca Giampieri, Maurizio Antonio Battino, Xiumin Chen
Summary: Diabetes is a serious chronic disease worldwide, and GABA has good potential for anti-diabetic effects. This review summarizes the dietary sources of GABA, along with animal and human studies, while also discussing the mechanisms behind its anti-diabetic properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Tamara Y. Forbes-Hernandez, Alfonso Varela-Lopez, Juan G. Puentes, Raquel Del Pino-Garcia, Cristina Sanchez-Gonzalez, Inaki Elio, Maurizio Battino, Roberto Garcia, Sebastian Sanchez, Jose L. Quiles
Summary: In this study, olive leaves from different geographical origins were analyzed for their phytochemical profile, antioxidant capacity, neuroprotective activity, and anti-inflammatory effects. The results showed that olive leaves from Spain and Italy had the highest antioxidant and neuroprotective activities, while those from Greece had the lowest. The content of oleoside methyl ester and p-hydroxybenzoic acid in the Spanish and Italian samples, respectively, were strongly associated with these biological activities.
Article
Nutrition & Dietetics
Maria Vittoria Conti, Marco Gnesi, Naelijwa Mshanga, Rachele De Giuseppe, Francesca Giampieri, Hellas Cena
Summary: Food knowledge plays a significant role in addressing malnutrition conditions in developing countries, alongside food safety, food security, and food access. Understanding healthy nutrition concepts and adopting appropriate food behaviors and habits can improve the health status of vulnerable populations, such as Tanzanian women of childbearing age. The validated and easy-to-administer FK questionnaire presented in this study provides a comprehensive measure of individuals' FK, contributing to the evidence of its construct validity.
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
Article
Cultural Studies
Yijun Sun
Article
Food Science & Technology
Guanhua Lv, Hengpeng Wang, Xiaoou Wei, Minmin Lu, Wenhao Yang, Halah Aalim, Esra Capanoglu, Xiaobo Zou, Maurizio Battino, Di Zhang
Summary: This study investigated the effects of different cooking methods on chicken protein oxidation, structural and digestion characteristics, and the impact of undigested protein on intestinal flora fermentation. The results showed that roasting and deep-frying led to higher protein oxidation, while boiling resulted in the lowest oxidation. Stir-frying and deep-frying reduced protein digestibility and changed its structure. Roasting had the greatest impact on intestinal flora, generating the highest number of new species and exhibiting a lower production of short-chain fatty acids. The adverse effects on intestinal flora of stir-frying and deep-frying were not as significant as that of roasting.
Article
Food Science & Technology
Gabriela Pilco-Romero, Aida M. Chisaguano-Tonato, Maria E. Herrera-Fontana, Luis F. Chimbo-Gandarac, Majid Sharifi-Rad, Francesca Giampieri, Maurizio Battinof, Maria Gabriela Vernaza, Jose M. Alvarez-Suarez
Summary: The house cricket is a potential food resource with high digestibility protein and various nutrients. Research suggests that it could be used in the food industry, and its protein solubility and water retention capacity can be beneficial for creating nutritious products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Fausto Sebastian Cabezas-Mera, Maria Belen Atiencia-Carrera, Irina Villacres-Granda, Adrian Alexander Proano, Alexis Debut, Karla Vizuete, Lorena Herrero-Bayo, Ana M. Gonzalez-Paramas, Francesca Giampieri, Reinier Abreu-Naranjo, Eduardo Tejera, Jose M. Alvarez-Suarez, Antonio Machado
Summary: Stingless bee honey samples show antibiofilm activity against multidrug-resistant pathogens. The honey samples can reduce the biomass of biofilms and affect cell count and viability. Scanning electron microscopy analysis demonstrates structural disruption of biofilms by honey. The polyphenolic profile of honey samples varies according to geographical origin.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
