Review
Biochemistry & Molecular Biology
Yanhui Zhou, Hakim Manghwar, Weiming Hu, Fen Liu
Summary: Autophagy is a key pathway for nutrient recycling in eukaryotes, influenced by various factors such as hormones, second messengers, post-transcriptional regulation, and protein post-translational modification. It is activated under stress conditions to help cells survive, and the degradation mechanism of autophagy-related proteins in different organisms has attracted attention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ya'nan Dou, Jingjie An, Xiu Yan, Zhihong Dang, Jianglong Guo, Zhanlin Gao, Yaofa Li
Summary: In this study, the researchers investigated the influence of pre-exposure time at different temperatures on the toxicities of three temperature effect insecticides (positive, negative, and non-effect) to Apolygus lucorum. The results showed that pre-exposure time had an effect on the toxicities of the insecticides, with different patterns observed for each temperature effect insecticide. These findings contribute to a better understanding of the temperature effect on the toxicities of insecticides.
Review
Biochemistry & Molecular Biology
Hangjun Sun, Xinxin Jing, Chaonan Wang, Pengyue Wang, Ziting Huang, Bingjian Sun, Pengbai Li, Honglian Li, Chao Zhang
Summary: Plant viruses cause significant damage to global crop production and plants activate defense signaling pathways to hinder virus propagation. Protein homeostasis regulation plays a vital role in the ongoing battle between plants and viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jennifer Cable, Eilika Weber-Ban, Tim Clausen, Kylie J. Walters, Michal Sharon, Daniel J. Finley, Yangnan Gu, John Hanna, Yue Feng, Sascha Martens, Anne Simonsen, Malene Hansen, Hong Zhang, Jonathan M. Goodwin, Alessio Reggio, Chunmei Chang, Liang Ge, Brenda A. Schulman, Raymond J. Deshaies, Ivan Dikic, J. Wade Harper, Ingrid E. Wertz, Nicolas H. Thoma, Mikolaj Slabicki, Judith Frydman, Ursula Jakob, Della C. David, Eric J. Bennett, Carolyn R. Bertozzi, Richa Sardana, Vinay V. Eapen, Serena Carra
Summary: Targeted protein degradation is essential for cellular function and development. This process involves tightly regulated protein degradation pathways to eliminate misfolded and aggregated proteins, adjust protein levels during cellular differentiation, and selectively eliminate target proteins. Understanding these pathways can provide insights into disease pathology and the development of novel therapeutics.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Gastroenterology & Hepatology
May San Martinho, Derek J. Nancarrow, Theodore S. Lawrence, David G. Beer, Dipankar Ray
Summary: The incidence of esophageal adenocarcinoma and other gastrointestinal cancers is rising, emphasizing the need to identify oncogenic drivers to develop effective therapies. Targeting molecular chaperones that mediate mutant p53 stability may prove to be an effective strategy in improving cancer outcomes. Targeting the interaction of mutant p53 with E3 ubiquitin ligase isoforms like GRAIL could help mitigate esophageal adenocarcinoma development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pinduo Liu, Anping Wu, Hui Li, Jun Zhang, Junjun Ni, Zhenzhen Quan, Hong Qing
Summary: This study revealed the degradation pathways of Rab21 protein through the ubiquitin-proteasome pathway and the autophagy-lysosome pathway, and demonstrated increased ubiquitination of Rab21 protein in the AD model. Moreover, the study suggested the involvement of the autophagy-lysosome pathway in maintaining the protein level of Rab21.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
M. Roths, M. A. Abeyta, B. Wilson, T. E. Rudolph, M. B. Hudson, R. P. Rhoads, L. H. Baumgard, J. T. Selsby
Summary: Heat stress does not increase skeletal muscle proteolysis, contrary to previous beliefs, which calls into question the assumption that increased skeletal muscle proteolysis drives increased amino acid mobilization.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Physiology
Sebastian Koetter, Martina Krueger
Summary: This review explores the composition of the sarcomere, the smallest molecular unit of muscle contraction and relaxation, and focuses on the role of the sarcomere protein titin and its relationship with protein quality control. It summarizes the current state of research on titin turnover and discusses the involvement of various intracellular degradation mechanisms. Additionally, it examines how perturbations in protein quality control can affect sarcomeric proteins, particularly titin, in different disease states.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Angeles C. Tecalco-Cruz, Jose Pedraza-Chaverri, Alfredo Briones-Herrera, Eduardo Cruz-Ramos, Lilia Lopez-Canovas, Jesus Zepeda-Cervantes
Summary: This review investigates the altered pathways involved in proteostasis in AD, suggesting that studying these pathways is critical for identifying new biomarkers and target molecules for AD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Guiyou Tian, Cheng Hu, Yun Yun, Wensheng Yang, Wolfgang Dubiel, Yabin Cheng, Dieter A. Wolf
Summary: The study reveals the selective upregulation of HSP70-family chaperone HSPA1 and its co-factors, HSPH1 and DNAJB1, in breast cancer cells acquiring thermotolerance. HSPA1 plays dual roles in heat stress response, promoting protein degradation and synthesis during acute stress, and maintaining newly synthesized proteins in a soluble state during thermotolerance. Deletion of HSPH1 impedes thermotolerance and esophageal tumor growth in mice, suggesting a potential therapeutic target for cancer.
Article
Biology
Julie M. Neurohr, Erik T. Paulson, Stephen T. Kinsey
Summary: The study revealed that red muscle has a higher mitochondrial density but more oxidative damage, while white muscle has higher antioxidant enzyme activity; different tissues exhibit distinct protein degradation systems; red muscle has higher translation rate and ATP turnover, likely due to increased mitochondrial density and oxidative damage.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Cell Biology
Erik McShane, Matthias Selbach
Summary: Cellular protein degradation is an active and highly regulated process that has diverse roles in biological functions, including homeostasis, regulation, and quality control.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Lin Lyu, Zheng Chen, Nami McCarty
Summary: The study reveals TRIM44 as a novel link between the UPS system and autophagy pathway, which enhances aggregate protein clearance rate by promoting SQSTM1/p62 oligomerization and binding of K48 ubiquitin chains.
Article
Cell Biology
Sonia R. Singh, Moritz Meyer-Jens, Erda Alizoti, W. Clark Bacon, Gregory Davis, Hanna Osinska, James Gulick, Silke Reischmann-Duesener, Ellen Orthey, Patrick M. McLendon, Jeffery D. Molkentin, Saskia Schlossarek, Jeffrey Robbins, Lucie Carrier
Summary: The study revealed that ZNF418 activates the ALP, inhibits the UPS, and regulates genes associated with cardiomyocyte structure and function. RNA-seq analysis showed that ZNF418 also plays a role in regulating genes involved in cardiac development and/or hypertrophy.
Article
Biochemistry & Molecular Biology
Francesca Biagioni, Federica Mastroiacovo, Paola Lenzi, Stefano Puglisi-Allegra, Carla L. Busceti, Larisa Ryskalin, Rosangela Ferese, Domenico Bucci, Alessandro Frati, Ferdinando Nicoletti, Francesco Fornai
Summary: The peri-infarct region, known as the ischemic penumbra, is a critical area surrounding the irreversible ischemic stroke region where neuronal metabolic conditions are impaired. Over-expression of HSP70 is the classic biochemical marker of the penumbra, but other proteins related to cell clearing pathways are also modified in this area. LC3 and P20S are two proteins that show significant overlapping redistribution within the penumbra, with a reduction in autophagoproteasomes reported as a relevant sub-cellular alteration in this region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Akira Murakami, Atsushi Nesumi, Mari Maeda-Yamamoto, Hidekazu Yamaguchi, Koji Yashima, Masahiro Miura, Tsuyoshi Nakano, Kazunori Nekoshima
JOURNAL OF FOOD AND DRUG ANALYSIS
(2015)
Article
Pharmacology & Pharmacy
Akira Murakami
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2015)
Article
Multidisciplinary Sciences
Yoko Igarashi, Kohta Ohnishi, Kazuhiro Irie, Akira Murakami
Article
Biochemistry & Molecular Biology
Naoko Suga, Akira Murakami, Yoshimasa Nakamura, Akari Ishisaka, Noritoshi Kitamoto, Mikiko Ito, Yoji Kato
FREE RADICAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Akira Murakami, Kohjiro Nagao, Naoto Juni, Yuji Hara, Masato Umeda
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Toshiyuki Nakamura, Miho Hirakawa, Yoshimasa Nakamura, Akari Ishisaka, Noritoshi Kitamoto, Akira Murakami, Yoji Kato
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Review
Chemistry, Medicinal
Kohjiro Nagao, Akira Murakami, Masato Umeda
CHEMICAL & PHARMACEUTICAL BULLETIN
(2019)
Article
Plant Sciences
Nurmila Sari, Yasufumi Katanasaka, Yuga Sugiyama, Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Akira Murakami, Kiyoshi Mori, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
Summary: The study demonstrates that Zerumbone can inhibit the development of cardiac hypertrophy and fibrosis, thereby improving LV function. Both in vitro experiments and mouse models confirmed the effects of Zer on cardiac cells and cardiac fibroblasts.
Article
Cell Biology
Akira Murakami, Kohjiro Nagao, Reiko Sakaguchi, Keisuke Kida, Yuji Hara, Yasuo Mori, Kohki Okabe, Yoshie Harada, Masato Umeda
Summary: Intracellular temperature in animal cells remains unclear if it is autonomously controlled as a response to environmental temperature fluctuations. This study shows that the intracellular temperature in Drosophila S2 cells is maintained by the enzyme DESAT1, which enhances mitochondrial respiration and thermogenesis. Cold exposure also stimulates DESAT1-mediated mitochondrial remodeling, leading to increased temperature control.
Article
Plant Sciences
Yoichi Sunagawa, Shogo Kawaguchi, Yusuke Miyazaki, Yasufumi Katanasaka, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Toshihide Hamabe-Horiike, Yuto Kawase, Maki Komiyama, Kiyoshi Mori, Akira Murakami, Koji Hasegawa, Tatsuya Morimoto
Summary: In this study, it was found that auraptene has a protective effect against phenylephrine-induced cardiac hypertrophy and heart failure. Auraptene improves cardiac function by activating PPAR alpha and inhibiting cardiac hypertrophy and fibrosis in myocardial cells.
Article
Toxicology
Akira Murakami
Summary: Polyphenols in animals have beneficial effects by increasing the expression of antioxidative and xenobiotic-metabolizing enzymes, as well as inducing adaptive responses. Mild stressors can enhance the protective capacity of the body, while excessive stress can be harmful. Certain polyphenols can induce lipolysis and decrease intracellular ATP levels.
CURRENT OPINION IN TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Naoko Suga, Akira Murakami, Hideyuki Arimitsu, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoji Kato
Summary: The study showed that luteolin can suppress the increased levels of 5-hydroxytryptamine in experimental cells and colitis models by inhibiting the expression of tryptophan hydroxylase 1 and the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Naoko Suga, Akira Murakami, Hideyuki Arimitsu, Kazuya Shiogama, Sarasa Tanaka, Mikiko Ito, Yoji Kato
Summary: Myeloperoxidase-generated tryptamine-4,5-dione in inflammatory tissue may contribute to the development of inflammatory bowel disease, as indicated in this study.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Satoki Suihara, Akari Ishisaka, Akira Murakami
Summary: Green tea catechins, particularly EGCG, have been found to induce lipolysis in lipid-loaded cells by generating oxidative and proteo-stress, activating stress defense mechanisms and promoting glucose uptake for energy homeostasis. These findings suggest that EGCG compensates for ATP reduction through lipolysis to counteract its stress-inducing properties.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Cindy Valentine, Kohta Ohnishi, Kazuhiro Irie, Akira Murakami
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2019)