The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

(2018) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

B-cell Therapy for Multiple Sclerosis: Entering an era

(2018) Ariele L. Greenfield et al.   ANNALS OF NEUROLOGY

Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment

(2018) Jonathan J. Grist et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

(2018) Ivana Bjelobaba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination

(2018) Hawra Karim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic resonance markers of tissue damage related to connectivity disruption in multiple sclerosis

(2018) Elisabeth Solana et al.   NeuroImage-Clinical

Serum GFAP as a biomarker for disease severity in multiple sclerosis

(2018) A. Abdelhak et al.   Scientific Reports

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity

(2018) Heidi Högel et al.   Multiple Sclerosis Journal

Type I interferon pathway in CNS homeostasis and neurological disorders

(2017) Thomas Blank et al.   GLIA

Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging

(2017) Ivan I. Kirov et al.   HUMAN BRAIN MAPPING

Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation

(2017) David Voigt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

GFAP in early multiple sclerosis: A biomarker for inflammation

(2017) Rebecca Kassubek et al.   NEUROSCIENCE LETTERS

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

(2017) Veit Rothhammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2017) Han Gao et al.   Cell Reports

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

Astrocytes in multiple sclerosis

(2016) Samuel K Ludwin et al.   Multiple Sclerosis Journal

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Astrocytes in multiple sclerosis

(2016) Samuel K Ludwin et al.   Multiple Sclerosis Journal

Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes

(2016) Pekka Poutiainen et al.   Frontiers in Molecular Neuroscience

Brain Metabolite Changes in Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis: A Two-Year Follow-Up Study

(2016) Dorothea Obert et al.   PLoS One

Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

(2015) Agata A. Mossakowski et al.   ACTA NEUROPATHOLOGICA

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses

(2015) Vincent Sénécal et al.   GLIA

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System

(2015) Matteo M. Guerrini et al.   IMMUNITY

Tumor necrosis factor stimulates expression of CXCL12 in astrocytes

(2015) Jana Blaževski et al.   IMMUNOBIOLOGY

Silencing IFN-γ Binding/Signaling in Astrocytes versus Microglia Leads to Opposite Effects on Central Nervous System Autoimmunity

(2015) Xiaoli Ding et al.   JOURNAL OF IMMUNOLOGY

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis

(2015) Carine Savarin et al.   Journal of Neuroinflammation

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

(2015) Andreia Barateiro et al.   MOLECULAR NEUROBIOLOGY

Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis

(2015) M Alba Mañé Martínez et al.   Multiple Sclerosis Journal

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation

(2015) Juan G. Zarruk et al.   NEUROBIOLOGY OF DISEASE

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

(2015) Jorge Ivan Alvarez et al.   NEUROBIOLOGY OF DISEASE

Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica

(2015) Katsuhisa Masaki   NEUROPATHOLOGY

Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice

(2015) H. Chen et al.   NEUROSCIENCE

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption

(2015) Hyung-Mun Yun et al.   Oncotarget

Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis

(2015) M Alba Mañé Martínez et al.   Multiple Sclerosis Journal

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

(2014) Gaelle Elain et al.   GLIA

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

(2014) Philip G. Nijland et al.   GLIA

Interleukin-17 (IL-17)-induced MicroRNA 873 (miR-873) Contributes to the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting A20 Ubiquitin-editing Enzyme

(2014) Xiaomei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation

(2014) Debayon Paul et al.   Journal of Neuroinflammation

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model

(2014) Emily Mills Ko et al.   Journal of Neuroinflammation

Gender Differences in Multiple Sclerosis

(2014) Sabina Luchetti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oligodendrocyte Gap Junction Loss and Disconnection From Reactive Astrocytes in Multiple Sclerosis Gray Matter

(2014) Kyriaki Markoullis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

11C-Acetate PET Imaging in Patients with Multiple Sclerosis

(2014) Kazushiro Takata et al.   PLoS One

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Magnetic Resonance Spectroscopy Markers of Disease Progression in Multiple Sclerosis

(2014) Sara Llufriu et al.   JAMA Neurology

Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients

(2014) Marloes Prins et al.   Acta Neuropathologica Communications

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

(2014) Philip G Nijland et al.   Acta Neuropathologica Communications

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

(2013) Xu Wang et al.   ACTA NEUROPATHOLOGICA

Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-11C]acetate

(2013) Maki Okada et al.   APPLIED RADIATION AND ISOTOPES

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

Roles for HB-EGF and CD9 in multiple sclerosis

(2013) Geert J. Schenk et al.   GLIA

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER  Signaling on Astrocytes But Not through ER  Signaling on Astrocytes or Neurons

(2013) R. D. Spence et al.   JOURNAL OF NEUROSCIENCE

Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica

(2013) Katsuhisa Masaki et al.   PLoS One

Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

(2012) Jigisha R. Patel et al.   ACTA NEUROPATHOLOGICA

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

(2012) Kyriaki Markoullis et al.   ACTA NEUROPATHOLOGICA

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

(2012) Marie T. Fischer et al.   BRAIN

Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis

(2012) Xu Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism

(2012) Nutabi Camargo et al.   FASEB JOURNAL

Regulation of CCL20 expression in astrocytes by IL-6 and IL-17

(2012) Gordon P. Meares et al.   GLIA

Deletion of Astroglial Connexins Weakens the Blood–Brain Barrier

(2012) Pascal Ezan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis

(2012) Roberta Brambilla et al.   Journal of Neuroinflammation

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability

(2012) Claudia Hindinger et al.   PLoS One

Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination

(2011) De-Hyung Lee et al.   ACTA NEUROPATHOLOGICA

The neuropathological basis of clinical progression in multiple sclerosis

(2011) Richard Reynolds et al.   ACTA NEUROPATHOLOGICA

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

(2011) R. A. Linker et al.   BRAIN

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients

(2011) George P. Christophi et al.   CLINICAL IMMUNOLOGY

Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet

(2011) Susan Noell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Labeled Acetate as a Marker of Astrocytic Metabolism

(2011) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions

(2011) Timothy J Seabrook et al.   Journal of Neuroinflammation

Macroglial Plasticity and the Origins of Reactive Astroglia in Experimental Autoimmune Encephalomyelitis

(2011) F. Guo et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease

(2010) Henrik Toft-Hansen et al.   GLIA

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

(2010) Ruben Van Doorn et al.   GLIA

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of Astrocyte-Derived IL-15 to CD8 T Cell Effector Functions in Multiple Sclerosis

(2010) P. Saikali et al.   JOURNAL OF IMMUNOLOGY

Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis

(2010) M. Axelsson et al.   JOURNAL OF NEUROLOGY

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

(2010) J. R. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of astrocyte polarity marks blood–brain barrier impairment during experimental autoimmune encephalomyelitis

(2009) Karen Wolburg-Buchholz et al.   ACTA NEUROPATHOLOGICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments

(2009) Hong Pham et al.   JOURNAL OF NEUROIMMUNOLOGY

Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis

(2009) Jayasri Sarma et al.   Journal of Neuroinflammation

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Astrocytes and the regulation of cerebral blood flow

(2009) Raymond C. Koehler et al.   TRENDS IN NEUROSCIENCES

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

(2008) Erin E. McCandless et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1

(2008) Kakuri M. Omari et al.   AMERICAN JOURNAL OF PATHOLOGY

Paradoxical dysregulation of the neural stem cell pathway sonic hedgehog-gli1 in autoimmune encephalomyelitis and multiple sclerosis

(2008) Yue Wang et al.   ANNALS OF NEUROLOGY

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

(2008) J. van Horssen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stimulation-Induced Increases of Astrocytic Oxidative Metabolism in Rats and Humans Investigated with 1-11C-Acetate

(2008) Matthias T Wyss et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

(2008) Moran Meiron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease

(2008) Jian Luo et al.   Journal of Neuroinflammation

Expression of TWEAK and Its Receptor Fn14 in the Multiple Sclerosis Brain: Implications for Inflammatory Tissue Injury

(2008) Barbara Serafini et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY