Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis

Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE

(2014) M. Moreno et al.   JOURNAL OF NEUROSCIENCE

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

(2014) I. L. Campbell et al.   JOURNAL OF NEUROSCIENCE

Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis

(2013) Pramod K. Mishra et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting Interleukin-6 in Rheumatoid Arthritis

(2013) Md Yuzaiful Md Yusof et al.   DRUGS

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation

(2013) Ulrike Gimsa et al.   MEDIATORS OF INFLAMMATION

Disease-modifying treatments for progressive multiple sclerosis

(2013) Giancarlo Comi   Multiple Sclerosis Journal

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior

(2012) Albert Quintana et al.   BRAIN BEHAVIOR AND IMMUNITY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

(2012) Mercedes Rincon et al.   International Journal of Biological Sciences

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability

(2012) Claudia Hindinger et al.   PLoS One

Interleukin-6, a mental cytokine

(2011) Anneleen Spooren et al.   BRAIN RESEARCH REVIEWS

Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

(2011) F. Haroon et al.   JOURNAL OF IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5

(2010) J. A. Black et al.   BRAIN

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

The effects of IL-6 on CD4 T cell responses

(2008) Oliver Dienz et al.   CLINICAL IMMUNOLOGY

Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis

(2008) Alexandre S. Basso et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

(2008) Satoshi Serada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA