Type I interferon pathway in CNS homeostasis and neurological disorders

SAMHD1, the Aicardi-Goutières syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonuclease

(2016) Jeongmin Ryoo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

(2016) Thomas Blank et al.   IMMUNITY

Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein

(2016) Liyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity

(2016) Katrin Peschke et al.   JOURNAL OF IMMUNOLOGY

Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages

(2016) Ashleigh Howes et al.   JOURNAL OF IMMUNOLOGY

Minocycline attenuates interferon-α-induced impairments in rat fear extinction

(2016) Qiang Bi et al.   Journal of Neuroinflammation

Induction of the type I interferon response in neurological forms of Gaucher disease

(2016) Einat B. Vitner et al.   Journal of Neuroinflammation

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Interferon-β1a modulates glutamate neurotransmission in the CNS through CaMKII and GluN2A-containing NMDA receptors

(2016) Massimiliano Di Filippo et al.   NEUROPHARMACOLOGY

Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord

(2016) Satoru Oji et al.   PLoS One

Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology

(2016) Aleksandra Deczkowska et al.   TRENDS IN IMMUNOLOGY

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

(2016) Line S. Reinert et al.   Nature Communications

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

(2016) Yuki Murakami et al.   Scientific Reports

Comparative efficacy of disease-modifying therapies for patients with relapsing remitting multiple sclerosis: Systematic review and network meta-analysis

(2016) Emer Fogarty et al.   Multiple Sclerosis and Related Disorders

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

(2016) Myles R. Minter et al.   Acta Neuropathologica Communications

STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α

(2016) Shota Yamauchi et al.   Scientific Reports

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis

(2015) Reza Khorooshi et al.   ACTA NEUROPATHOLOGICA

Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome

(2015) Mi-Ae Jang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome

(2015) Frank Rutsch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

(2015) Katarzyna Blaszczyk et al.   BIOCHEMICAL JOURNAL

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C

(2015) Carol Murray et al.   BRAIN BEHAVIOR AND IMMUNITY

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use

(2015) Guido Antonelli et al.   CYTOKINE & GROWTH FACTOR REVIEWS

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

(2015) Line Lykke Andersen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs

(2015) Ali A. Abdul-Sater et al.   JOURNAL OF IMMUNOLOGY

Interferon-α Induces Neurotoxicity Through Activation of the Type I Receptor and the GluN2A Subunit of the NMDA Receptor

(2015) Cari F. Kessing et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

(2015) Cathleen Pfefferkorn et al.   JOURNAL OF VIROLOGY

Brain Invasion by Mouse Hepatitis Virus Depends on Impairment of Tight Junctions and Beta Interferon Production in Brain Microvascular Endothelial Cells

(2015) Christian Bleau et al.   JOURNAL OF VIROLOGY

Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice

(2015) Lian-Shun Zheng et al.   Frontiers in Cellular Neuroscience

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Central Role of ULK1 in Type I Interferon Signaling

(2015) Diana Saleiro et al.   Cell Reports

IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity

(2015) Magdalena Kocur et al.   Acta Neuropathologica Communications

Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations

(2014) Hirotsugu Oda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

(2014) Xianqin Zhang et al.   NATURE

Can we measure long-term treatment effects in multiple sclerosis?

(2014) Maria Pia Sormani et al.   Nature Reviews Neurology

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Central Nervous System Herpes Simplex and Varicella Zoster Virus Infections in Natalizumab-Treated Patients

(2013) A. J. Fine et al.   CLINICAL INFECTIOUS DISEASES

TLR3 immunity to infection in mice and humans

(2013) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Interferons in the central nervous system: A few instruments play many tunes

(2013) Trevor Owens et al.   GLIA

Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration

(2013) T. Farfel-Becker et al.   HUMAN MOLECULAR GENETICS

PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients

(2013) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Interferon-β1a protects neurons against mitochondrial toxicity via modulation of STAT1 signaling: Electrophysiological evidence

(2013) Massimiliano Di Filippo et al.   NEUROBIOLOGY OF DISEASE

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Brain dendritic cells: biology and pathology

(2012) Paul M. D’Agostino et al.   ACTA NEUROPATHOLOGICA

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

How type I interferons shape myeloid cell function in CNS autoimmunity

(2012) S. M. Brendecke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Viral disruption of the blood–brain barrier

(2012) Katherine R. Spindler et al.   TRENDS IN MICROBIOLOGY

Type I interferonopathies: a novel set of inborn errors of immunity

(2011) Yanick J. Crow   Annals of the New York Academy of Sciences

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

The Type I Interferon-  Mediates a More Severe Neurological Disease in the Absence of the Canonical Signaling Molecule Interferon Regulatory Factor 9

(2010) M. J. Hofer et al.   JOURNAL OF NEUROSCIENCE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS

(2010) Marco Prinz et al.   TRENDS IN MOLECULAR MEDICINE

Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?

(2009) Christopher D. Conrady et al.   JOURNAL OF NEUROIMMUNOLOGY

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB/c and C57Bl/6 mice

(2008) G.-Y. G. Tan et al.   JOURNAL OF MEDICAL MICROBIOLOGY

BRAIN DAMAGE AS DETECTED BY cDNA-MICROARRAY IN THE SPINAL FLUID OF PATIENTS WITH AICARDI-GOUTIERES SYNDROME

(2008) A. Izzotti et al.   NEUROLOGY