Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation
出版年份 2017 全文链接
标题
Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 8, Pages 2012-2017
出版商
Proceedings of the National Academy of Sciences
发表日期
2017-02-07
DOI
10.1073/pnas.1615413114
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke
- (2016) Melissa A. Lopes Pinheiro et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia
- (2016) Maryam Nazari et al. BRAIN RESEARCH BULLETIN
- Sphingosine-1-Phosphate Receptors in the Central Nervous and Immune Systems
- (2016) Luke Healy et al. CURRENT DRUG TARGETS
- Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
- (2016) Hsing-Chuan Tsai et al. DRUGS
- The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
- (2016) Catherine O’Sullivan et al. Journal of Neuroinflammation
- Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis
- (2016) Mauricio F. Farez et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial
- (2016) Fred Lublin et al. LANCET
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
- (2016) Veit Rothhammer et al. NATURE MEDICINE
- Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments
- (2016) Faik Imeri et al. NEUROPHARMACOLOGY
- The emerging role of FTY720 (Fingolimod) in cancer treatment
- (2016) Christopher White et al. Oncotarget
- Safety and Efficacy of Siponimod (BAF312) in Patients With Relapsing-Remitting Multiple Sclerosis
- (2016) Ludwig Kappos et al. JAMA Neurology
- Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection
- (2016) Irina V. Tiper et al. Pathogens and Disease
- Astrocyte pathology in Alexander disease causes a marked inflammatory environment
- (2015) Markel Olabarria et al. ACTA NEUROPATHOLOGICA
- MS565: A SPECT Tracer for Evaluating the Brain Penetration of BAF312 (Siponimod)
- (2015) Emmanuelle Briard et al. ChemMedChem
- Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
- (2015) Richard L. Proia et al. JOURNAL OF CLINICAL INVESTIGATION
- Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis
- (2015) Carine Savarin et al. Journal of Neuroinflammation
- Pathological mechanisms in progressive multiple sclerosis
- (2015) Don H Mahad et al. LANCET NEUROLOGY
- Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro
- (2015) STEFANIE JANSSEN et al. Molecular Medicine Reports
- Astrocyte barriers to neurotoxic inflammation
- (2015) Michael V. Sofroniew NATURE REVIEWS NEUROSCIENCE
- Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice
- (2015) H. Chen et al. NEUROSCIENCE
- Control of autoimmune CNS inflammation by astrocytes
- (2015) Veit Rothhammer et al. Seminars in Immunopathology
- Astrocytes Control Synapse Formation, Function, and Elimination
- (2015) Won-Suk Chung et al. Cold Spring Harbor Perspectives in Biology
- The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple Sclerosis
- (2015) Prenitha Mercy Ignatius Arokia Doss et al. Frontiers in Immunology
- Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide
- (2014) Emanuela Colombo et al. ANNALS OF NEUROLOGY
- Mechanisms of white matter damage in multiple sclerosis
- (2014) Hans Lassmann GLIA
- Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond
- (2014) Christopher S. Garris et al. IMMUNOLOGY
- Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis
- (2014) Roy Y. Kim et al. JOURNAL OF NEUROIMMUNOLOGY
- Conditional Ablation of Astroglial CCL2 Suppresses CNS Accumulation of M1 Macrophages and Preserves Axons in Mice with MOG Peptide EAE
- (2014) M. Moreno et al. JOURNAL OF NEUROSCIENCE
- Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial
- (2014) Peter A Calabresi et al. LANCET NEUROLOGY
- Sphingolipid metabolites in inflammatory disease
- (2014) Michael Maceyka et al. NATURE
- Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation
- (2014) Lior Mayo et al. NATURE MEDICINE
- Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model
- (2014) Daniel C. Anthony et al. NEUROPHARMACOLOGY
- Fingolimod for the treatment of neurological diseases—state of play and future perspectives
- (2014) Robert Brunkhorst et al. Frontiers in Cellular Neuroscience
- The astrocyte in multiple sclerosis revisited
- (2013) Celia F. Brosnan et al. GLIA
- FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats
- (2013) Masoumeh Asle-Rousta et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
- (2013) Celina Wu et al. Journal of Neuroinflammation
- Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy
- (2013) Aran Groves et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
- (2013) Tobias Goldmann et al. NATURE NEUROSCIENCE
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- White matter astrocytes in health and disease
- (2013) I. Lundgaard et al. NEUROSCIENCE
- Fingolimod Therapy for Multiple Sclerosis
- (2013) Mary Willis et al. SEMINARS IN NEUROLOGY
- Modeling the heterogeneity of multiple sclerosis in animals
- (2013) Sarah B. Simmons et al. TRENDS IN IMMUNOLOGY
- Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
- (2013) Shifeng Pan et al. ACS Medicinal Chemistry Letters
- Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
- (2013) G. K. Sheridan et al. Open Biology
- IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
- (2012) Hui-Rong Jiang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Progressive multiple sclerosis: pathology and pathogenesis
- (2012) Hans Lassmann et al. Nature Reviews Neurology
- The initiation and prevention of multiple sclerosis
- (2012) Alberto Ascherio et al. Nature Reviews Neurology
- Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model
- (2011) Hye Jung Kim et al. FASEB JOURNAL
- S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures
- (2011) Graham K. Sheridan et al. GLIA
- Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
- (2011) Bahareh Ajami et al. NATURE NEUROSCIENCE
- Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy
- (2011) R. Hohlfeld et al. NEUROLOGY
- Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
- (2011) T. Hla et al. NEUROLOGY
- Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
- (2011) M. Mehling et al. NEUROLOGY
- Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
- (2010) Veronique E. Miron et al. AMERICAN JOURNAL OF PATHOLOGY
- Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (Fingolimod) in multiple sclerosis
- (2010) Chang Wook Lee et al. ARCHIVES OF PHARMACAL RESEARCH
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis
- (2010) Jerold Chun et al. CLINICAL NEUROPHARMACOLOGY
- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
- (2010) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
- (2010) J. W. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
- (2009) Alexander Mildner et al. BRAIN
- FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
- (2009) Volker Brinkmann BRITISH JOURNAL OF PHARMACOLOGY
- Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
- (2009) Mauricio F Farez et al. NATURE IMMUNOLOGY
- FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage
- (2008) Carolyn A. Foster et al. BRAIN PATHOLOGY
- Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
- (2008) Alexandre S. Basso et al. JOURNAL OF CLINICAL INVESTIGATION
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started