Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats

(2017) Muammer Üçal et al.   EXPERIMENTAL NEUROLOGY

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

(2017) Bernhard Josef Rüther et al.   GLIA

Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone-induced demyelination

(2017) Emily G. Baxi et al.   GLIA

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy

(2017) Ana Beatriz DePaula-Silva et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Strain differences in cuprizone induced demyelination

(2017) Qili Yu et al.   Cell and Bioscience

Histological validation of fast macromolecular proton fraction mapping as a quantitative myelin imaging method in the cuprizone demyelination model

(2017) Marina Yu Khodanovich et al.   Scientific Reports

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Ageing and recurrent episodes of neuroinflammation promote progressive experimental autoimmune encephalomyelitis in Biozzi ABH mice

(2016) Laura A. N. Peferoen et al.   IMMUNOLOGY

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

(2016) S. Anwar Jagessar et al.   JOURNAL OF IMMUNOLOGY

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

(2016) Saskia Maria Burm et al.   Journal of Neuroinflammation

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

(2016) M. Scheld et al.   JOURNAL OF NEUROSCIENCE

Male rats develop more severe experimental autoimmune encephalomyelitis than female rats: Sexual dimorphism and diergism at the spinal cord level

(2015) Mirjana Nacka-Aleksić et al.   BRAIN BEHAVIOR AND IMMUNITY

Ozone Therapy in Ethidium Bromide-Induced Demyelination in Rats: Possible Protective Effect

(2015) Neveen A. Salem et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?

(2015) Sabrina Ruhrmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anatomical Distribution of Cuprizone-Induced Lesions in C57BL6 Mice

(2015) Johannes Goldberg et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Whole-BodyIn VivoMonitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice

(2015) Makiko Hayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Class II HLA interactions modulate genetic risk for multiple sclerosis

(2015) Loukas Moutsianas et al.   NATURE GENETICS

Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase

(2015) Iva Bozic et al.   Analytical Cellular Pathology

Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells

(2015) Iva Bozic et al.   Frontiers in Cellular Neuroscience

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

(2015) Michael B. Keough et al.   Jove-Journal of Visualized Experiments

Cell death of spinal cord ED1+cells in a rat model of multiple sclerosis

(2015) Dragana Trifunović et al.   PeerJ

Stage-Specific Role of Interferon-Gamma in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

(2015) Gabriel Arellano et al.   Frontiers in Immunology

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia

(2015) Iva Bozic et al.   PLoS One

Analysis of Neurogenesis during Experimental Autoimmune Encephalomyelitis Reveals Pitfalls of Bioluminescence Imaging

(2015) Ilya Ayzenberg et al.   PLoS One

The formation of inflammatory demyelinated lesions in cerebral white matter

(2014) Pietro Maggi et al.   ANNALS OF NEUROLOGY

Cutting Edge: Multiple Sclerosis-Like Lesions Induced by Effector CD8 T Cells Recognizing a Sequestered Antigen on Oligodendrocytes

(2014) A. Saxena et al.   JOURNAL OF IMMUNOLOGY

Relapsing-Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

(2014) K. Sasaki et al.   JOURNAL OF IMMUNOLOGY

Expression of a Second Ecto-5′-Nucleotidase Variant Besides the Usual Protein in Symptomatic Phase of Experimental Autoimmune Encephalomyelitis

(2014) Irena Lavrnja et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats

(2014) Gonçalo Castelo-Branco et al.   NEUROBIOLOGY OF DISEASE

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

(2014) S. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Parent-of-Origin Effects Implicate Epigenetic Regulation of Experimental Autoimmune Encephalomyelitis and Identify Imprinted Dlk1 as a Novel Risk Gene

(2014) Pernilla Stridh et al.   PLoS Genetics

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

(2014) Stefan Bittner et al.   Jove-Journal of Visualized Experiments

Experimental autoimmune encephalomyelitis is a good model of multiple sclerosis if used wisely

(2014) David Baker et al.   Multiple Sclerosis and Related Disorders

EAE is not a useful model for demyelinating disease

(2014) Peter O. Behan et al.   Multiple Sclerosis and Related Disorders

Multiple Sclerosis: Molecular Mechanisms and Therapeutic Opportunities

(2013) Djordje Miljković et al.   ANTIOXIDANTS & REDOX SIGNALING

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

(2013) Christopher Gardner et al.   BRAIN

Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord

(2013) Nicholas J. Kuypers et al.   EXPERIMENTAL NEUROLOGY

Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice

(2013) Cecile Delarasse et al.   IMMUNOLOGY

B Cells Promote Induction of Experimental Autoimmune Encephalomyelitis by Facilitating Reactivation of T Cells in the Central Nervous System

(2013) E. R. Pierson et al.   JOURNAL OF IMMUNOLOGY

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

(2013) Fabiola Puentes et al.   Journal of Neuroinflammation

Theiler’s murine encephalomyelitis virus as an experimental model system to study the mechanism of blood–brain barrier disruption

(2013) Holly L. Johnson et al.   JOURNAL OF NEUROVIROLOGY

Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

(2013) Caroline Guglielmetti et al.   NEUROIMAGE

Functional Imaging of Rel Expression in Inflammatory Processes Using Bioluminescence Imaging System in Transgenic Mice

(2013) Xingyu Yang et al.   PLoS One

Functional diversity of microglia – how heterogeneous are they to begin with?

(2013) Uwe-Karsten Hanisch   Frontiers in Cellular Neuroscience

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

The Role of Natural Killer Cells in Multiple Sclerosis and Their Therapeutic Implications

(2013) Coralie Chanvillard et al.   Frontiers in Immunology

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

(2013) David W Hampton et al.   Acta Neuropathologica Communications

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination

(2012) Lucas Silvestroff et al.   EXPERIMENTAL NEUROLOGY

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

(2012) J. P. Buschmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain

(2012) Charlotte Schmitt et al.   Journal of Neuroinflammation

B-Cell Depletion Abrogates T Cell-Mediated Demyelination in an Antibody-Nondependent Common Marmoset Experimental Autoimmune Encephalomyelitis Model

(2012) S. Anwar Jagessar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Preclinical Retinal Neurodegeneration in a Model of Multiple Sclerosis

(2012) R. Fairless et al.   JOURNAL OF NEUROSCIENCE

Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss

(2012) Vivian Doan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis

(2012) Irena Lavrnja et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The evidence for a role of B cells in multiple sclerosis

(2012) G. Disanto et al.   NEUROLOGY

Viral models of multiple sclerosis: Neurodegeneration and demyelination in mice infected with Theiler's virus

(2012) Miriam Mecha et al.   PROGRESS IN NEUROBIOLOGY

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

(2011) M. Kipp et al.   BRAIN BEHAVIOR AND IMMUNITY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Experimental models of multiple sclerosis

(2011) Andrew R Pachner   CURRENT OPINION IN NEUROLOGY

Astrocytes in the tempest of multiple sclerosis

(2011) Djordje Miljković et al.   FEBS LETTERS

Astrocyte phenotypes and their relationship to myelination

(2011) Besma Nash et al.   JOURNAL OF ANATOMY

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

(2011) Sarah Al-Izki et al.   Multiple Sclerosis Journal

Critical appraisal of animal models of multiple sclerosis

(2011) David Baker et al.   Multiple Sclerosis Journal

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

(2011) Sarah Al-Izki et al.   Multiple Sclerosis and Related Disorders

Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm

(2010) Helena Batoulis et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Mouse models for multiple sclerosis: Historical facts and future implications

(2010) Andrew L. Croxford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Animal Model of Cortical and Callosal Pathology in Multiple Sclerosis

(2010) Mario Mangiardi et al.   BRAIN PATHOLOGY

Age-Related and Cuprizone-Induced Changes in Myelin and Transcription Factor Gene Expression and in Oligodendrocyte Cell Densities in the Rostral Corpus Callosum of Mice

(2010) J. Ronald Doucette et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor

(2010) Masanori Sasaki et al.   GLIA

Induction of Progressive Demyelinating Autoimmune Encephalomyelitis in Common Marmoset Monkeys Using MOG34-56Peptide in Incomplete Freund Adjuvant

(2010) S. Anwar Jagessar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

(2010) Qingyong Ji et al.   NATURE IMMUNOLOGY

A critical role for virus-specific CD8+ CTLs in protection from Theiler's virus-induced demyelination in disease-susceptible SJL mice

(2010) Meghann Teague Getts et al.   VIROLOGY

The histopathology of grey matter demyelination in multiple sclerosis

(2009) L. Bø   ACTA NEUROLOGICA SCANDINAVICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Cuprizone Demyelination of the Corpus Callosum in Mice Correlates with Altered Social Interaction and Impaired Bilateral Sensorimotor Coordination

(2009) Norah Hibbits et al.   ASN Neuro

SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination

(2009) Lorelei C. Taylor et al.   BRAIN PATHOLOGY

Multiple loci comprising immune-related genes regulate experimental neuroinflammation

(2009) M Marta et al.   GENES AND IMMUNITY

Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development

(2009) Yolanda S. Kap et al.   Journal of Neuroimmune Pharmacology

Neuropathogenesis of Theiler’s Murine Encephalomyelitis Virus Infection, An Animal Model for Multiple Sclerosis

(2009) Ikuo Tsunoda et al.   Journal of Neuroimmune Pharmacology

The Innate Immune Response to Adjuvants Dictates the Adaptive Immune Response to Autoantigens

(2009) Maria A. Staykova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Quantification of Myelin and Axon Pathology During Relapsing Progressive Experimental Autoimmune Encephalomyelitis in the Biozzi ABH Mouse

(2009) Samuel J. Jackson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle

(2009) Lorelei C. Taylor et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contrasting roles for Vα14+natural killer T cells in a viral model for multiple sclerosis

(2009) Ikuo Tsunoda et al.   JOURNAL OF NEUROVIROLOGY

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

(2009) Amke Hesse et al.   NEUROBIOLOGY OF DISEASE

Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis

(2009) Irena Lavrnja et al.   NEUROCHEMISTRY INTERNATIONAL

Neuromyelitis optica with intraspinal expansion of Schwann cell remyelination

(2009) Hayato Ikota et al.   NEUROPATHOLOGY

Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination

(2009) Maren Lindner et al.   NEUROSCIENCE LETTERS

Modeling multiple sclerosis in laboratory animals

(2009) Bettina Schreiner et al.   Seminars in Immunopathology

Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent

(2008) Thomas Skripuletz et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice

(2008) Limei Li et al.   BMC IMMUNOLOGY

Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system

(2008) Shin-Young Na et al.   BRAIN

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production

(2008) Irena Lavrnja et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss

(2008) David W. Hampton et al.   JOURNAL OF NEUROIMMUNOLOGY

Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease

(2008) Jian Luo et al.   Journal of Neuroinflammation

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE

In Vitro and In Vivo Pharmacological Models to Assess Demyelination and Remyelination

(2008) Jean E Merrill   NEUROPSYCHOPHARMACOLOGY

Therapeutic effects of combined treatment with ribavirin and tiazofurin on experimental autoimmune encephalomyelitis development: Clinical and histopathological evaluation

(2007) Danijela Stojkov et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES