标题
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
作者
关键词
-
出版物
Nature Reviews Cardiology
Volume 15, Issue 9, Pages 523-542
出版商
Springer Nature America, Inc
发表日期
2018-07-27
DOI
10.1038/s41569-018-0061-5
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Anti-senescence compounds: A potential nutraceutical approach to healthy aging
- (2018) Felicia Gurău et al. AGEING RESEARCH REVIEWS
- Strategies for Optimal Cardiovascular Aging
- (2018) Douglas R. Seals et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection
- (2018) Nunzia D'Onofrio et al. ANTIOXIDANTS & REDOX SIGNALING
- Extranuclear Sirtuins and Metabolic Stress
- (2018) Mahmoud-Sobhy Elkhwanky et al. ANTIOXIDANTS & REDOX SIGNALING
- Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury
- (2018) Lin Wang et al. CARDIOVASCULAR RESEARCH
- Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial
- (2018) Erin J. Howden et al. CIRCULATION
- Mechanisms of Cardiac Repair and Regeneration
- (2018) Kathleen M. Broughton et al. CIRCULATION RESEARCH
- Induced Pluripotent Stem Cell (iPSC)–Derived Exosomes for Precision Medicine in Heart Failure
- (2018) Phillip C. Yang CIRCULATION RESEARCH
- Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit+Cardiac Stem Cells As Regenerative Therapy for Heart Failure)Novelty and Significance
- (2018) Roberto Bolli et al. CIRCULATION RESEARCH
- New Insights Into the Role of mTOR Signaling in the Cardiovascular System
- (2018) Sebastiano Sciarretta et al. CIRCULATION RESEARCH
- Cardiac c-Kit Biology Revealed by Inducible TransgenesisNovelty and Significance
- (2018) Natalie A. Gude et al. CIRCULATION RESEARCH
- Telomeres and telomerase in heart regeneration
- (2018) Esther Aix et al. DIFFERENTIATION
- Short telomeres — A hallmark of heritable cardiomyopathies
- (2018) Alex C.Y. Chang et al. DIFFERENTIATION
- Combining cell and gene therapy to advance cardiac regeneration
- (2018) Pina Marotta et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- The role of DNA methylation in coronary artery disease
- (2018) Lian Duan et al. GENE
- Epigenetics and cardiovascular regenerative medicine in the elderly
- (2018) Sarah Costantino et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Effects of d -galactose-induced ageing on the heart and its potential interventions
- (2018) Cherry Bo-Htay et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Arrhythmias in Patients ≥80 Years of Age
- (2018) Anne B. Curtis et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study
- (2018) Rudy Sinharay et al. LANCET
- Stress, cell senescence and organismal ageing
- (2018) João Pedro de Magalhães et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
- (2018) Andrew D. Stephens et al. MOLECULAR BIOLOGY OF THE CELL
- The complex biology of KIT+ cells in the heart
- (2018) Giovanni Maroli et al. Nature Reviews Cardiology
- Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart
- (2018) Fiona C. Lewis et al. PHARMACOLOGICAL RESEARCH
- Curcumin in heart failure: A choice for complementary therapy?
- (2018) Amin Saeidinia et al. PHARMACOLOGICAL RESEARCH
- Pericytes and cardiac stem cells: Common features and peculiarities
- (2018) Antonio Paolo Beltrami et al. PHARMACOLOGICAL RESEARCH
- Chasing c-Kit through the heart: Taking a broader view
- (2018) Natalie A. Gude et al. PHARMACOLOGICAL RESEARCH
- Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing
- (2018) Yu Zhang et al. PHYSIOLOGICAL REVIEWS
- Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster
- (2018) Jason G. Wood et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate
- (2018) Collin Matsumoto et al. STEM CELLS
- Mitochondrial quality control: The role of mitophagy in aging
- (2018) Ruoyang Shi et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect
- (2018) Dolores Corella et al. Annual Review of Food Science and Technology
- Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo
- (2018) Ralf Gilsbach et al. Nature Communications
- Cross-talk between microtubules and the linker of nucleoskeleton complex plays a critical role in the adipogenesis of human adipose-derived stem cells
- (2018) Yiting Yang et al. Stem Cell Research & Therapy
- Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart
- (2018) Daniel A. Skelly et al. Cell Reports
- Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
- (2018) Jun-Nan Tang et al. Stem Cells Translational Medicine
- Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing
- (2018) Chengzu Long et al. Science Advances
- ‘Reprogrammed’ stem cells approved to mend human hearts for the first time
- (2018) David Cyranoski NATURE
- Long-term indoor air conditioner filtration and cardiovascular health: A randomized crossover intervention study
- (2017) Hsiao-Chi Chuang et al. ENVIRONMENT INTERNATIONAL
- Accumulative effects of indoor air pollution exposure on leukocyte telomere length among non-smokers
- (2017) Nan Lin et al. ENVIRONMENTAL POLLUTION
- Cardiomyocyte renewal in the human heart: insights from the fall-out
- (2017) Enikő Lázár et al. EUROPEAN HEART JOURNAL
- Mechanisms driving the ageing heart
- (2017) Rhys Anderson et al. EXPERIMENTAL GERONTOLOGY
- Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle
- (2017) Andrew T. Ludlow et al. EXPERIMENTAL PHYSIOLOGY
- TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan
- (2017) Girish C. Melkani et al. FEBS LETTERS
- mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
- (2017) Thomas Weichhart GERONTOLOGY
- Acute stress-induced (takotsubo) cardiomyopathy
- (2017) Dana K Dawson HEART
- Telomere length as a potential biomarker of coronary artery disease
- (2017) Joyeeta Bhattacharyya et al. INDIAN JOURNAL OF MEDICAL RESEARCH
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency
- (2017) Christina V. Theodoris et al. JOURNAL OF CLINICAL INVESTIGATION
- Preexisting endothelial cells mediate cardiac neovascularization after injury
- (2017) Lingjuan He et al. JOURNAL OF CLINICAL INVESTIGATION
- The extracellular matrix in myocardial injury, repair, and remodeling
- (2017) Nikolaos G. Frangogiannis JOURNAL OF CLINICAL INVESTIGATION
- Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease
- (2017) Faisal J. Alibhai et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Time-restricted feeding for prevention and treatment of cardiometabolic disorders
- (2017) Girish C. Melkani et al. JOURNAL OF PHYSIOLOGY-LONDON
- Leukocyte telomere length and mortality among U.S. adults: Effect modification by physical activity behaviour
- (2017) Paul D. Loprinzi et al. JOURNAL OF SPORTS SCIENCES
- A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration
- (2017) Makoto Natsumeda et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Basic Biology of Oxidative Stress and the Cardiovascular System
- (2017) Michael N. Sack et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The Aging Cardiovascular System
- (2017) Francesco Paneni et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
- (2017) Gregory A. Roth et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Analysis of Polymorphisms in 58 Potential Candidate Genes for Association with Human Longevity
- (2017) Timothy A Donlon et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- To stay young, kill zombie cells
- (2017) Megan Scudellari NATURE
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Heart in space: effect of the extraterrestrial environment on the cardiovascular system
- (2017) Richard L. Hughson et al. Nature Reviews Cardiology
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
- (2017) Kathleen A. Hershberger et al. Nature Reviews Nephrology
- Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape
- (2017) Andrey Tvardovskiy et al. NUCLEIC ACIDS RESEARCH
- Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals
- (2017) Niria Treviño-Saldaña et al. Oxidative Medicine and Cellular Longevity
- Heart regeneration and the cardiomyocyte cell cycle
- (2017) Michael Hesse et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Curcumin as a potential protective compound against cardiac diseases
- (2017) Shuai Jiang et al. PHARMACOLOGICAL RESEARCH
- Cardiac telomere length in heart development, function, and disease
- (2017) S. A. Booth et al. PHYSIOLOGICAL GENOMICS
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms
- (2017) Frank W. Booth et al. PHYSIOLOGICAL REVIEWS
- Reliability of transcardiopulmonary thermodilution cardiac output measurement in experimental aortic valve insufficiency
- (2017) Martin Petzoldt et al. PLoS One
- Physical activity and telomere length in U.S. men and women: An NHANES investigation
- (2017) Larry A. Tucker PREVENTIVE MEDICINE
- Epigenetic clock analysis in long-term meditators
- (2017) Raphaëlle Chaix et al. PSYCHONEUROENDOCRINOLOGY
- Rejuvenation of Cardiac Tissue Developed from Reprogrammed Aged Somatic Cells
- (2017) Zhao Cheng et al. REJUVENATION RESEARCH
- Cardiac regeneration strategies: Staying young at heart
- (2017) Eldad Tzahor et al. SCIENCE
- Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™)
- (2017) Vinaykumar Tripathi et al. Stem Cell Reviews and Reports
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
- (2017) Peter K. Joshi et al. Nature Communications
- Caloric restriction delays age-related methylation drift
- (2017) Shinji Maegawa et al. Nature Communications
- Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
- (2017) Ana Arpón et al. Nutrients
- Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction
- (2017) Zheng Zhang et al. Stem Cell Research & Therapy
- Less Than Ideal Cardiovascular Health Is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys, 1999–2002
- (2017) Samson Y. Gebreab et al. Journal of the American Heart Association
- Chronic Psychological Stress Accelerates Vascular Senescence and Impairs Ischemia‐Induced Neovascularization: The Role of Dipeptidyl Peptidase‐4/Glucagon‐Like Peptide‐1‐Adiponectin Axis
- (2017) Limei Piao et al. Journal of the American Heart Association
- Current insights into LMNA cardiomyopathies: Existing models and missing LINCs
- (2017) Daniel Brayson et al. Nucleus
- Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™)
- (2017) Vinaykumar Tripathi et al. Stem Cell Reviews and Reports
- The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
- (2017) Jan R. Aunan et al. Aging and Disease
- Psychological Stress, Inflammation, and Coronary Heart Disease
- (2017) Petra H. Wirtz et al. Current Cardiology Reports
- Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons
- (2017) Yu Tang et al. Frontiers in Molecular Neuroscience
- Human Pathophysiological Adaptations to the Space Environment
- (2017) Gian C. Demontis et al. Frontiers in Physiology
- Current insights into LMNA cardiomyopathies: Existing models and missing LINCs
- (2017) Daniel Brayson et al. Nucleus
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort
- (2017) Cavin K. Ward-Caviness et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Persistent Long-Term Structural, Functional, and Metabolic Changes After Stress-Induced (Takotsubo) Cardiomyopathy
- (2017) Caroline Scally et al. CIRCULATION
- Genetic Architecture of the Cardiovascular Risk Proteome
- (2017) Mark D. Benson et al. CIRCULATION
- Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study
- (2016) Hao Peng et al. Aging-US
- Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
- (2016) Brandon M. Hall et al. Aging-US
- RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease
- (2016) Dean Gilham et al. ATHEROSCLEROSIS
- Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia–reperfusion injury
- (2016) Guo-Qing Du et al. BASIC RESEARCH IN CARDIOLOGY
- Epigenetic Mechanisms of Longevity and Aging
- (2016) Payel Sen et al. CELL
- Metabolic Control of Longevity
- (2016) Carlos López-Otín et al. CELL
- Large animal models of cardiovascular disease
- (2016) H. G. Tsang et al. CELL BIOCHEMISTRY AND FUNCTION
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Macromolecular Degradation Systems and Cardiovascular Aging
- (2016) Hiroyuki Nakayama et al. CIRCULATION RESEARCH
- Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?Response to Harper et al
- (2016) Shavonn C. Harper et al. CIRCULATION RESEARCH
- Mechanical Regulation of Cardiac Aging in Model Systems
- (2016) Ayla O. Sessions et al. CIRCULATION RESEARCH
- Telomere Shortening, Regenerative Capacity, and Cardiovascular OutcomesNovelty and Significance
- (2016) Muhammad Hammadah et al. CIRCULATION RESEARCH
- A Large-Scale Investigation of Hypoxia-Preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Nonhuman PrimatesNovelty and Significance
- (2016) Xinyang Hu et al. CIRCULATION RESEARCH
- The Role of DNA Methylation in Cardiovascular Risk and Disease
- (2016) Jia Zhong et al. CIRCULATION RESEARCH
- Mediterranean diet and telomere length in high cardiovascular risk subjects from the PREDIMED-NAVARRA study
- (2016) Sonia García-Calzón et al. CLINICAL NUTRITION
- Building and re-building the heart by cardiomyocyte proliferation
- (2016) Matthew J. Foglia et al. DEVELOPMENT
- Mental stress-induced myocardial ischaemia
- (2016) S S Arri et al. HEART
- Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation
- (2016) Esther Aix et al. JOURNAL OF CELL BIOLOGY
- Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart
- (2016) JoAnn Trial et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Pim1 Kinase Overexpression Enhances ckit + Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine
- (2016) Shathiyah Kulandavelu et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mouse models of ageing and their relevance to disease
- (2016) Sulev Kõks et al. MECHANISMS OF AGEING AND DEVELOPMENT
- The Aging Epigenome
- (2016) Lauren N. Booth et al. MOLECULAR CELL
- The Mitochondrial Basis of Aging
- (2016) Nuo Sun et al. MOLECULAR CELL
- Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
- (2016) N Fujitsuka et al. MOLECULAR PSYCHIATRY
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- Cardioprotection and lifespan extension by the natural polyamine spermidine
- (2016) Tobias Eisenberg et al. NATURE MEDICINE
- Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase
- (2016) Kaitlen Samse et al. PHARMACOLOGICAL RESEARCH
- Mode-specific physical activity and leukocyte telomere length among U.S. adults: Implications of running on cellular aging
- (2016) Paul D. Loprinzi et al. PREVENTIVE MEDICINE
- Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
- (2016) Alex Chia Yu Chang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Social relationships and physiological determinants of longevity across the human life span
- (2016) Yang Claire Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study
- (2016) Laura Salvador et al. REJUVENATION RESEARCH
- Recent advancements in understanding endogenous heart regeneration—insights from adult zebrafish and neonatal mice
- (2016) Nicole Rubin et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Metabolic Impact on Histone Acetylation and Transcription in Ageing
- (2016) Shahaf Peleg et al. TRENDS IN BIOCHEMICAL SCIENCES
- Anti-Aging Strategies Based on Cellular Reprogramming
- (2016) Alejandro Ocampo et al. TRENDS IN MOLECULAR MEDICINE
- Discovering cardiac pericyte biology: From physiopathological mechanisms to potential therapeutic applications in ischemic heart disease
- (2016) Elisa Avolio et al. VASCULAR PHARMACOLOGY
- Nutritional Genomics and the Mediterranean Diet’s Effects on Human Cardiovascular Health
- (2016) Montserrat Fitó et al. Nutrients
- Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs
- (2016) Antonia Piazzesi et al. Cell Reports
- Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults
- (2016) David H. Rehkopf et al. PLOS MEDICINE
- Nutrigerontology: a key for achieving successful ageing and longevity
- (2016) Anna Aiello et al. Immunity & Ageing
- Human longevity: Genetics or Lifestyle? It takes two to tango
- (2016) Giuseppe Passarino et al. Immunity & Ageing
- Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type
- (2016) Carlos C. Crestani Frontiers in Physiology
- Cellular Senescence as the Causal Nexus of Aging
- (2016) Naina Bhatia-Dey et al. Frontiers in Genetics
- CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells
- (2016) Seung-Hee Lee et al. Aging-US
- Progerin expression disrupts critical adult stem cell functions involved in tissue repair
- (2016) Laurin Marie Pacheco et al. Aging-US
- Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis)
- (2015) Evelyne Saade et al. AGING CELL
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Health effects of intermittent fasting: hormesis or harm? A systematic review
- (2015) Benjamin D Horne et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The role of sirtuins in cardiac disease
- (2015) Shouji Matsushima et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury
- (2015) Rebecca J Godar et al. Autophagy
- Cardiomyocyte Cell-Cycle Activity during Preadolescence
- (2015) Mark H. Soonpaa et al. CELL
- No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice
- (2015) Kanar Alkass et al. CELL
- Dynamics of Cell Generation and Turnover in the Human Heart
- (2015) Olaf Bergmann et al. CELL
- Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling PathwayCLINICAL PERSPECTIVE
- (2015) Satoshi Araki et al. CIRCULATION
- Cardiac Stem Cell Hybrids Enhance Myocardial RepairNovelty and Significance
- (2015) Pearl Quijada et al. CIRCULATION RESEARCH
- GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance
- (2015) Shavonn C. Smith et al. CIRCULATION RESEARCH
- Revisiting Cardiac Cellular CompositionNovelty and Significance
- (2015) Alexander R. Pinto et al. CIRCULATION RESEARCH
- “String Theory” of c-kitposCardiac Cells
- (2015) Matthew C.L. Keith et al. CIRCULATION RESEARCH
- Epigenetics of Aging
- (2015) Marta Sierra et al. CURRENT GENOMICS
- Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration
- (2015) Ahmed I. Mahmoud et al. DEVELOPMENTAL CELL
- Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
- (2015) Stephan Winnik et al. EUROPEAN HEART JOURNAL
- FOXO3: A Major Gene for Human Longevity - A Mini-Review
- (2015) Brian J. Morris et al. GERONTOLOGY
- Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells
- (2015) Kaitlen Samse et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries
- (2015) Mingyi Wang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- This old heart: Cardiac aging and autophagy
- (2015) Phyllis-Jean Linton et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Non-sirtuin histone deacetylases in the control of cardiac aging
- (2015) Bradley S. Ferguson et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Genome-wide association studies of late-onset cardiovascular disease
- (2015) J.Gustav Smith et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cardiac aging — Getting to the stem of the problem
- (2015) Nirmala Hariharan et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Sirtuin function in aging heart and vessels
- (2015) Chiara Cencioni et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ageing, metabolism and cardiovascular disease
- (2015) Sarah Costantino et al. JOURNAL OF PHYSIOLOGY-LONDON
- Leisure-Time Screen-Based Sedentary Behavior and Leukocyte Telomere Length: Implications for a New Leisure-Time Screen-Based Sedentary Behavior Mechanism
- (2015) Paul D. Loprinzi MAYO CLINIC PROCEEDINGS
- The metabolic regulation of aging
- (2015) Toren Finkel NATURE MEDICINE
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Epigenetic regulation of ageing: linking environmental inputs to genomic stability
- (2015) Bérénice A. Benayoun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Exercise Attenuates the Major Hallmarks of Aging
- (2015) Nuria Garatachea et al. REJUVENATION RESEARCH
- Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection
- (2015) E. H. Blackburn et al. SCIENCE
- Time-restricted feeding attenuates age-related cardiac decline in Drosophila
- (2015) S. Gill et al. SCIENCE
- Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
- (2015) Pedro Gomes et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
- (2015) Kristen Fortney et al. PLoS Genetics
- Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians
- (2015) Yasumichi Arai et al. EBioMedicine
- How Cardiomyocytes Make the Heart Old
- (2015) Zoltan Papp et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Intermittent Fasting Results in Tissue-Specific Changes in Bioenergetics and Redox State
- (2015) Bruno Chausse et al. PLoS One
- Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart
- (2015) Tania I. Fuentes et al. PLoS One
- Histone methylation and aging: Lessons learned from model systems
- (2014) Brenna S. McCauley et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number
- (2014) Nawazish Naqvi et al. CELL
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- CENP-A is essential for cardiac progenitor cell proliferation
- (2014) Michael McGregor et al. CELL CYCLE
- A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function
- (2014) Dongryeol Ryu et al. Cell Metabolism
- Adult c-kit pos Cardiac Stem Cells Fulfill Koch’s Postulates as Causal Agents for Cardiac Regeneration
- (2014) Daniele Torella et al. CIRCULATION RESEARCH
- Metabolic Dysfunction Consistent With Premature Aging Results From Deletion of Pim Kinases
- (2014) Shabana Din et al. CIRCULATION RESEARCH
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Genome wide DNA methylation profiling for epigenetic alteration in coronary artery disease patients
- (2014) Priyanka Sharma et al. GENE
- Histone variants: dynamic punctuation in transcription
- (2014) C. M. Weber et al. GENES & DEVELOPMENT
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
- (2014) Joris Deelen et al. HUMAN MOLECULAR GENETICS
- Effects of 5 days of head-down bed rest, with and without short-arm centrifugation as countermeasure, on cardiac function in males (BR-AG1 study)
- (2014) E. G. Caiani et al. JOURNAL OF APPLIED PHYSIOLOGY
- Aging and epigenetic drift: a vicious cycle
- (2014) Jean-Pierre Issa JOURNAL OF CLINICAL INVESTIGATION
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
- (2014) Linda Broer et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Mesenchymal–endothelial transition contributes to cardiac neovascularization
- (2014) Eric Ubil et al. NATURE
- Medical research: Treat ageing
- (2014) Luigi Fontana et al. NATURE
- Complex I Deficiency Due to Selective Loss of Ndufs4 in the Mouse Heart Results in Severe Hypertrophic Cardiomyopathy
- (2014) Edward T. Chouchani et al. PLoS One
- Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice
- (2014) S. R. Ali et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging
- (2014) Namgyu Lee et al. PROTEOMICS
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult
- (2014) Bernardo Nadal-Ginard et al. Stem Cell Research
- Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
- (2014) Luis F. Duarte et al. Nature Communications
- Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
- (2014) P. C. Haycock et al. BMJ-British Medical Journal
- The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
- (2014) Sarah J. Mitchell et al. Cell Reports
- Stress and Cardiovascular Disease: An Update on Current Knowledge
- (2013) Andrew Steptoe et al. Annual Review of Public Health
- Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats
- (2013) Camila Rosa et al. Cardiovascular Diabetology
- Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair
- (2013) Georgina M. Ellison et al. CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage
- (2013) Mirko Völkers et al. CIRCULATION
- Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase
- (2013) Sadia Mohsin et al. CIRCULATION RESEARCH
- PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity
- (2013) Mirko Völkers et al. EMBO Molecular Medicine
- Premature Impairment of Methylation Pathway and Cardiac Metabolic Dysfunction in fa/fa Obese Zucker Rats
- (2013) Nuria M. de Castro et al. JOURNAL OF PROTEOME RESEARCH
- Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy
- (2013) Foteini Mourkioti et al. NATURE CELL BIOLOGY
- Senescent cells harbour features of the cancer epigenome
- (2013) Hazel A. Cruickshanks et al. NATURE CELL BIOLOGY
- Identification of seven loci affecting mean telomere length and their association with disease
- (2013) Veryan Codd et al. NATURE GENETICS
- Cardiac Aging and Rejuvenation — A Sense of Humors?
- (2013) Thomas A. Rando et al. NEW ENGLAND JOURNAL OF MEDICINE
- AgeFactDB—the JenAge Ageing Factor Database—towards data integration in ageing research
- (2013) Rolf Hühne et al. NUCLEIC ACIDS RESEARCH
- Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup
- (2013) Kevin A. Strauss et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via -adrenergic induction of myelopoiesis
- (2013) N. D. Powell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cardiomyocyte proliferation contributes to heart growth in young humans
- (2013) Mariya Mollova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Natural Product Telomerase Activator as Part of a Health Maintenance Program: Metabolic and Cardiovascular Response
- (2013) Calvin B. Harley et al. REJUVENATION RESEARCH
- Reducing indoor air pollution by air conditioning is associated with improvements in cardiovascular health among the general population
- (2013) Lian-Yu Lin et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins
- (2013) Andrew T. Ludlow et al. Biomed Research International
- Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia
- (2013) Damir Hamamdzic et al. Journal of Diabetes Research
- Do we age faster in absence of gravity?
- (2013) Camillo Di Giulio Frontiers in Physiology
- Mouse models of laminopathies
- (2012) Haoyue Zhang et al. AGING CELL
- Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
- (2012) Irina M. Conboy et al. CELL CYCLE
- Administration of Cardiac Stem Cells in Patients With Ischemic Cardiomyopathy: The SCIPIO Trial: Surgical Aspects and Interim Analysis of Myocardial Function and Viability by Magnetic Resonance
- (2012) A. R. Chugh et al. CIRCULATION
- Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome
- (2012) Holger Heyn et al. Epigenetics
- Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair
- (2012) Sadia Mohsin et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Chronic Exercise Modifies Age-Related Telomere Dynamics in a Tissue-Specific Fashion
- (2012) Andrew T. Ludlow et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
- (2012) Mika Kivimäki et al. LANCET
- Mammalian heart renewal by pre-existing cardiomyocytes
- (2012) Samuel E. Senyo et al. NATURE
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- (2012) Nagalingam R Sundaresan et al. NATURE MEDICINE
- Stress and cardiovascular disease
- (2012) Andrew Steptoe et al. Nature Reviews Cardiology
- mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases
- (2012) Z. Yang et al. Obesity Reviews
- Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
- (2012) F. J. Ramos et al. Science Translational Medicine
- Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
- (2012) Tobias Wijshake et al. PLoS Genetics
- Historical review, epidemiology and natural history of degenerative mitral valve disease
- (2012) Michele Borgarelli et al. Journal of Veterinary Cardiology
- The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
- (2011) Bruno Bernardes de Jesus et al. AGING CELL
- Effects of Age and Heart Failure on Human Cardiac Stem Cell Function
- (2011) Daniela Cesselli et al. AMERICAN JOURNAL OF PATHOLOGY
- Cellular Senescence, Vascular Disease, and Aging
- (2011) Jason C. Kovacic et al. CIRCULATION
- Cellular Senescence, Vascular Disease, and Aging
- (2011) Jason C. Kovacic et al. CIRCULATION
- Molecular mechanisms of cardiomyocyte aging
- (2011) Anna Sheydina et al. CLINICAL SCIENCE
- DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death
- (2011) Anne T. Bertrand et al. HUMAN MOLECULAR GENETICS
- Cardiovascular Changes During Maturation and Ageing in Male and Female Spontaneously Hypertensive Rats
- (2011) Vincent Chan et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Obesity Induces Signs of Premature Cardiac Aging in Younger Patients
- (2011) Bernd Niemann et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
- (2011) Roberto Bolli et al. LANCET
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin
- (2011) D. Avitabile et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transient Regenerative Potential of the Neonatal Mouse Heart
- (2011) E. R. Porrello et al. SCIENCE
- Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
- (2011) F. G. Osorio et al. Science Translational Medicine
- Post-natal myogenic and adipogenic developmental
- (2011) Nard Kubben et al. Nucleus
- Genetic variation in insulin/IGF-1 signaling pathways and longevity
- (2010) Elad Ziv et al. AGEING RESEARCH REVIEWS
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
- (2010) Alessandra Sacco et al. CELL
- Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion
- (2010) Chiao-Po Hsu et al. CIRCULATION
- Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
- (2010) Nirmala Hariharan et al. CIRCULATION RESEARCH
- Cellular senescence: putting the paradoxes in perspective
- (2010) Judith Campisi CURRENT OPINION IN GENETICS & DEVELOPMENT
- Roles of Werner syndrome protein in protection of genome integrity
- (2010) Marie L. Rossi et al. DNA REPAIR
- The role of inflammatory and fibrogenic pathways in heart failure associated with aging
- (2010) Wei Chen et al. HEART FAILURE REVIEWS
- Characterization of a Transgenic Short Hairpin RNA-Induced Murine Model of Tafazzin Deficiency
- (2010) Meghan S. Soustek et al. HUMAN GENE THERAPY
- Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome
- (2010) Devrim Acehan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevated Histone Expression Promotes Life Span Extension
- (2010) Jason Feser et al. MOLECULAR CELL
- Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
- (2010) Roderick J O'Sullivan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
- (2009) Ludmila Pawlikowska et al. AGING CELL
- Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase
- (2009) Kimberlee M. Fischer et al. CIRCULATION
- Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall
- (2009) Christian Werner et al. CIRCULATION
- CENPA a Genomic Marker for Centromere Activity and Human Diseases
- (2009) Manuel Valdivia et al. CURRENT GENOMICS
- Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
- (2009) Mirjam Hoxha et al. Environmental Health
- An operational definition of epigenetics
- (2009) S. L. Berger et al. GENES & DEVELOPMENT
- Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats
- (2009) Ruiqian Wan et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Histone H4 lysine 16 acetylation regulates cellular lifespan
- (2009) Weiwei Dang et al. NATURE
- Evidence for Cardiomyocyte Renewal in Humans
- (2009) Olaf Bergmann et al. SCIENCE
- Caloric restriction, SIRT1 and longevity
- (2009) Carles Cantó et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
- (2008) Olesya Vakhrusheva et al. CIRCULATION RESEARCH
- Myocardial Induction of Nucleostemin in Response to Postnatal Growth and Pathological Challenge
- (2008) Sailay Siddiqi et al. CIRCULATION RESEARCH
- The Aging Cardiomyocyte: A Mini-Review
- (2008) D. Bernhard et al. GERONTOLOGY
- Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches
- (2008) Vanja Pekovic et al. JOURNAL OF ANATOMY
- Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway
- (2008) Rajesh G. Katare et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Effects of Physical Exercise on Myocardial Telomere-Regulating Proteins, Survival Pathways, and Apoptosis
- (2008) Christian Werner et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cellular senescence and organismal aging
- (2008) Jessie C. Jeyapalan et al. MECHANISMS OF AGEING AND DEVELOPMENT
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started