Mouse models of laminopathies

Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell?

(2016) Meghan K. Driscoll et al.   Aging-US

B-type lamins and their elusive roles in metazoan cell proliferation and senescence

(2012) Christopher J Hutchison   EMBO JOURNAL

Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

(2012) H.-J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Stem cell depletion in Hutchinson-Gilford progeria syndrome

(2011) Ylva Rosengardten et al.   AGING CELL

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Lamin A/C deficiency is associated with fat infiltration of muscle and bone

(2011) Jessica Tong et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice

(2011) Wei Li et al.   PLoS One

Differential Temporal and Spatial Progerin Expression during Closure of the Ductus Arteriosus in Neonates

(2011) Regina Bökenkamp et al.   PLoS One

Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

(2011) Y. Kim et al.   SCIENCE

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Post-natal myogenic and adipogenic developmental

(2011) Nard Kubben et al.   Nucleus

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

(2010) B. S. J. Davies et al.   HUMAN MOLECULAR GENETICS

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

(2010) Shao H. Yang et al.   HUMAN MOLECULAR GENETICS

Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice

(2010) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Lamins

(2010) T. Dechat et al.   Cold Spring Harbor Perspectives in Biology

Laminopathies and the long strange trip from basic cell biology to therapy

(2009) Howard J. Worman et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin

(2008) Y. Wang et al.   HUMAN MOLECULAR GENETICS

Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

(2008) H. Sagelius et al.   JOURNAL OF CELL SCIENCE

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

(2008) Shao H. Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

(2008) B. C. Capell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA