Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans

(2016) Mohammad M. Rahman et al.   Aging-US

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

(2016) Nan Jiang et al.   Aging-US

Accelerated epigenetic aging in Down syndrome

(2015) Steve Horvath et al.   AGING CELL

DNA Methylation on N6-Adenine in C. elegans

(2015) Eric Lieberman Greer et al.   CELL

N6-Methyladenine DNA Modification in Drosophila

(2015) Guoqiang Zhang et al.   CELL

N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas

(2015) Ye Fu et al.   CELL

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span

(2015) Mintie Pu et al.   GENES & DEVELOPMENT

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Aging alters histone H3 lysine 4 methylation in mouse germinal vesicle stage oocytes

(2015) Gen-Bao Shao et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing

(2015) D. A. Cusanovich et al.   SCIENCE

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

(2014) Antero Salminen et al.   AGEING RESEARCH REVIEWS

RNA-seq of the aging brain in the short-lived fishN. furzeri- conserved pathways and novel genes associated with neurogenesis

(2014) Mario Baumgart et al.   AGING CELL

Cytosine DNA Methylation Is Found in Drosophila melanogaster but Absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Other Yeast Species

(2014) Floriana Capuano et al.   ANALYTICAL CHEMISTRY

Regulating the Chromatin Landscape: Structural and Mechanistic Perspectives

(2014) Blaine Bartholomew   Annual Review of Biochemistry

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency

(2014) Bérénice A. Benayoun et al.   CELL

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response

(2014) Weiwei Dang et al.   Cell Metabolism

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Circadian clock: linking epigenetics to aging

(2014) Ricardo Orozco-Solis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

PIWI proteins and PIWI-interacting RNAs in the soma

(2014) Robert J. Ross et al.   NATURE

Epigenome-wide association studies without the need for cell-type composition

(2014) James Zou et al.   NATURE METHODS

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

AMPK regulates histone H2B O-GlcNAcylation

(2014) Qiuran Xu et al.   NUCLEIC ACIDS RESEARCH

Acute Aerobic Exercise Increases Cortical Activity during Working Memory: A Functional MRI Study in Female College Students

(2014) Lin Li et al.   PLoS One

SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line

(2014) Shana C. Kerr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic inheritance uncoupled from sequence-specific recruitment

(2014) K. Ragunathan et al.   SCIENCE

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

H3K27me and PRC2 transmit a memory of repression across generations and during development

(2014) L. J. Gaydos et al.   SCIENCE

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transgenerational epigenetics in the germline cycle of Caenorhabditis elegans

(2014) William G Kelly   Epigenetics & Chromatin

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

The SET-2/SET1 Histone H3K4 Methyltransferase Maintains Pluripotency in the Caenorhabditis elegans Germline

(2014) Valérie J. Robert et al.   Cell Reports

Reduced Insulin/IGF-1 Signaling Restores Germ Cell Immortality to Caenorhabditis elegans Piwi Mutants

(2014) Matt Simon et al.   Cell Reports

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

(2014) Eric L. Greer et al.   Cell Reports

Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility

(2014) Timothy G. Jenkins et al.   PLoS Genetics

Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans

(2014) Arnaud Tauffenberger et al.   PLoS Genetics

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

Cryptochromerestores dampened circadian rhythms and promotes healthspan in agingDrosophila

(2013) Kuntol Rakshit et al.   AGING CELL

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

H3K4 demethylase activities repress proliferative and postmitotic aging

(2013) Stacy M. Alvares et al.   AGING CELL

Genome Instability and Aging

(2013) Jan Vijg et al.   Annual Review of Physiology

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

(2013) M. Wahlestedt et al.   BLOOD

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

The circadian epigenome: how metabolism talks to chromatin remodeling

(2013) Lorena Aguilar-Arnal et al.   CURRENT OPINION IN CELL BIOLOGY

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

(2013) M. T. Reilly et al.   JOURNAL OF NEUROSCIENCE

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

The nexus of chromatin regulation and intermediary metabolism

(2013) Philipp Gut et al.   NATURE

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity

(2013) Christian G. Riedel et al.   NATURE CELL BIOLOGY

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

Activation of transposable elements during aging and neuronal decline in Drosophila

(2013) Wanhe Li et al.   NATURE NEUROSCIENCE

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

Functional implications of genome topology

(2013) Giacomo Cavalli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Estrogen represses gene expression through reconfiguring chromatin structures

(2013) Hatice Ulku Osmanbeyoglu et al.   NUCLEIC ACIDS RESEARCH

A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan

(2013) Mayumi Hachinohe et al.   PLoS One

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

(2013) Clare B. Edwards et al.   PLoS One

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1

(2013) Marina M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1

(2013) A. H. Ludewig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mating Induces Shrinking and Death in Caenorhabditis Mothers

(2013) C. Shi et al.   SCIENCE

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward

(2013) C. M. Gendron et al.   SCIENCE

Males Shorten the Life Span of C. elegans Hermaphrodites via Secreted Compounds

(2013) T. J. Maures et al.   SCIENCE

Bridging the transgenerational gap with epigenetic memory

(2013) Jana P. Lim et al.   TRENDS IN GENETICS

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

(2013) Kenneth Day et al.   GENOME BIOLOGY

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Deviation of innate circadian period from 24 h reduces longevity in mice

(2012) Sergiy Libert et al.   AGING CELL

Years of Life Gained Due to Leisure-Time Physical Activity in the U.S.

(2012) Ian Janssen et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter

(2012) Georgia Abate et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DNA damage, chromatin, and transcription: the trinity of aging

(2012) Rebecca C Burgess et al.   CURRENT OPINION IN CELL BIOLOGY

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Global heterochromatin loss

(2012) Amy Tsurumi et al.   Epigenetics

Exercise and longevity

(2012) Vincent Gremeaux et al.   MATURITAS

Expression Noise and Acetylation Profiles Distinguish HDAC Functions

(2012) Leehee Weinberger et al.   MOLECULAR CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

(2012) Matthew W Kellinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetically Heritable Alteration of Fly Development in Response to Toxic Challenge

(2012) Shay Stern et al.   Cell Reports

C. elegans Germ Cells Show Temperature and Age-Dependent Expression of Cer1, a Gypsy/Ty3-Related Retrotransposon

(2012) Shannon Dennis et al.   PLoS Pathogens

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans

(2011) Zhuoyu Ni et al.   AGING CELL

Histone exchange and histone modifications during transcription and aging

(2011) Chandrima Das et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Control of nuclear receptor function by local chromatin structure

(2011) Malgorzata Wiench et al.   FEBS Journal

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Circadian Rhythms, Aging, and Life Span in Mammals

(2011) Oren Froy   PHYSIOLOGY

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age

(2011) Qi Wang et al.   PLoS One

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrotransposition is associated with genome instability during chronological aging

(2011) P. H. Maxwell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells

(2011) Y. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Chromatin structure as a mediator of aging

(2010) Jason Feser et al.   FEBS LETTERS

Genome-wide gene expression regulation as a function of genotype and age in C. elegans

(2010) A. Vinuela et al.   GENOME RESEARCH

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

(2010) A. E. Teschendorff et al.   GENOME RESEARCH

Widespread and tissue specific age-related DNA methylation changes in mice

(2010) S. Maegawa et al.   GENOME RESEARCH

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation

(2010) Matthias Schaefer et al.   NATURE GENETICS

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity

(2010) D. C. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage

(2010) I. Manosalva et al.   THERIOGENOLOGY

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Oxaloacetate supplementation increases lifespan inCaenorhabditis elegansthrough an AMPK/FOXO-dependent pathway

(2009) David S. Williams et al.   AGING CELL

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1

(2009) M. Hatta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory

(2009) David J. Katz et al.   CELL

Caenorhabditis elegans pheromones regulate multiple complex behaviors

(2009) Arthur S Edison   CURRENT OPINION IN NEUROBIOLOGY

Calorie restriction and the exercise of chromatin

(2009) A. Vaquero et al.   GENES & DEVELOPMENT

Exercise-induced histone modifications in human skeletal muscle

(2009) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2

(2009) Sameer Phalke et al.   NATURE GENETICS

A quantitative model for age-dependent expression of the p16INK4a tumor suppressor

(2009) D. Tsygankov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

(2009) A. P. Siebold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

(2009) Lucinda K. Southworth et al.   PLoS Genetics

Evolution and mechanisms of long life and high fertility in queen honey bees

(2008) Silvia C. Remolina et al.   AGE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice

(2008) Chih-Wei Wu et al.   JOURNAL OF APPLIED PHYSIOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One