Article
Cardiac & Cardiovascular Systems
Klaus Neef, Florian Drey, Vera Lepperhof, Thorsten Wahlers, Jurgen Hescheler, Yeong-Hoon Choi, Tomo Saric
Summary: Co-transplantation of iPS-CM and MSC improves cardiac regeneration after myocardial damage, demonstrating the potential of combining multiple cell types for increasing the efficacy of future cardiac cell therapies. MSCs enhance the retention of iPS-CM and result in a significantly higher left ventricular ejection fraction (LVEF) when transplanted together.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell & Tissue Engineering
Sujitha Thavapalachandran, Thi Yen Loan Le, Sara Romanazzo, Fairooj N. Rashid, Masahito Ogawa, Kristopher A. Kilian, Paula Brown, Jim Pouliopoulos, Anthony M. Barry, Peter Fahmy, Kilian Kelly, Eddy Kizana, James J. H. Chong
Summary: The study demonstrates that iPSC-MSCs (Cymerus MSCs) provide better therapeutic effects for myocardial ischemia-reperfusion injury in a rodent model compared to conventional BM-MSCs, with safety and scalability for potential off-the-shelf stem cell therapy for cardiac repair.
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Hsuan Peng, Kazuhiro Shindo, Renee R. Donahue, Ahmed Abdel-Latif
Summary: Stem cell-based cardiac therapies present challenges in cell delivery, engraftment, and differentiation, but still lead to sustained cardiac benefits. Current research focuses on exploring the mechanisms of stem cell-mediated cardiac immunomodulation, with efforts to improve current strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Si-Jia Sun, Wing-Hon Lai, Yu Jiang, Zhe Zhen, Rui Wei, Qizhou Lian, Song-Yan Liao, Hung-Fat Tse
Summary: Pre-transplantation systemic intravenous administration of hiPSC-MSCs induced immunomodulation and facilitated the survival of intramyocardially transplanted cells to improve cardiac function in MI.
Article
Cell Biology
Dong Mei Xie, Yang Chen, Yan Liao, Wanwen Lin, Gang Dai, Di Han Lu, Shuanghua Zhu, Ke Yang, Bingyuan Wu, Zhihong Chen, Chaoquan Peng, Mei Hua Jiang
Summary: The study found that CD51 can serve as a marker for resident cardiac MSCs, and CD51(+)cMSC therapy enhances cardiac repair through promoting angiogenesis and a mechanism mediated by SCF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Weizhang Xiao, Ming Chen, Wenjing Zhou, Liang Ding, Ziying Yang, Lianbo Shao, Jingjing Li, Weiqian Chen, Zhenya Shen
Summary: This study found that the administration of an inhibitor of glycolysis, 2-DG, blocked the hyperinflammatory response within the ischemic myocardium and extended effective retention of transplanted MSCs. A novel chitosan/gelatin-based 2-DG patch was developed to directly facilitate MSC-mediated cardiac healing in the infarcted region.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Li-Na Zhang, Di-Di Zhang, Lei Yang, Yu-Xuan Gu, Qiu-Ping Zuo, Hao-Yi Wang, Jia Xu, Dian-Xin Liu
Summary: Invasion and metastasis are key characteristics of malignant tumors, with epithelial-mesenchymal transition (EMT) recognized as the initial step. Cell fusion, particularly involving mesenchymal stromal/stem cells (MSCs), plays a critical role in cancer development and progression, potentially influencing tumor growth and metastasis.
Article
Chemistry, Multidisciplinary
Shiqi Hu, Dashuai Zhu, Zhenhua Li, Ke Cheng
Summary: A detachable therapeutic microneedle patch has been developed to deliver mesenchymal stromal cell-secreted factors directly into the heart, showing promising potential for treatment.
Article
Cell & Tissue Engineering
Kashif Khan, Georges Makhoul, Bin Yu, Ghulam Jalani, Ida Derish, Alissa K. Rutman, Marta Cerruti, Adel Schwertani, Renzo Cecere
Summary: The study demonstrated that inserting human amniotic stromal mesenchymal stem cells (ASMCs) in a chitosan and hyaluronic acid (C/HA) based hydrogel significantly increased cardiac function and promoted new vessel formation in a rat myocardial infarction model. Proteomic profiling revealed that extracellular vesicles released from hypoxia-preconditioned ASMCs contained proteins involved in cytoprotection and angiogenesis.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu
Summary: Direct transplantation of mitochondria derived from mesenchymal stem cells (MSC-mt) can enhance blood vessel density, inhibit cardiac remodeling and apoptosis, thus improving heart function. MSC-mt also has protective effects on endothelial cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
David E. Ebeid, Farid G. Khalafalla, Kathleen M. Broughton, Megan M. Monsanto, Carolina Y. Esquer, Veronica Sacchi, Nirmala Hariharan, Kelli Korski, Maryam Moshref, Jacqueline Emathinger, Christopher T. Cottage, Pearl J. Quijada, Jonathan H. Nguyen, Roberto Alvarez, Mirko Volkers, Mathias H. Konstandin, Bingyan J. Wang, Fareheh Firouzi, Julian M. Navarrete, Natalie A. Gude, Marie-Jose Goumans, Mark A. Sussman
Summary: Pim1 maintains telomere lengths in cardiomyocytes by inhibiting phosphorylation of the TGF beta pathway downstream effectors Smad2 and Smad3, which prevents repression of telomerase reverse transcriptase.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Megan M. Monsanto, Fareheh Firouzi, Mark A. Sussman
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Oscar Echeagaray, Clarissa Savko, Andrea Gallo, Mark Sussman
Summary: This review summarizes the cardiovascular consequences of vaping and highlights the importance of research in this area. Recent findings indicate that vaping can have an impact on cardiovascular homeostasis, inflammation, and molecular changes, suggesting potential health issues associated with vaping and the need for further investigation into the pathogenesis.
CURRENT OPINION IN CARDIOLOGY
(2022)
Article
Biology
Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A. Sussman
Summary: Vaping of flavored liquids can lead to pulmonary injury, with profound pathological changes in upper airway, lung tissue, and cellular structure. This study also highlights the potential transcriptional reprogramming and impaired cardiac function associated with vaping.
LIFE SCIENCE ALLIANCE
(2022)
Review
Pharmacology & Pharmacy
Mark A. Sussman
Summary: Modern vaping, a rapidly growing industry, has raised concerns about its impact on human health, particularly on the lungs and cardiopulmonary system. Studies are urgently needed to understand the biological effects of vaping and develop strategies to mitigate the associated harmful effects.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Kathleen Broughton, Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan Monsanto, Dena Yaareb, Leila Golgolab, Natalie Gude, Mark A. Sussman
Summary: This study reveals that surface Lin28A serves as a marker for oxidative stress in cardiac interstitial cells (CICs) and its expression can be antagonized by antioxidant treatment. The altered localization of Lin28A is associated with senescence markers and oxidative stress pathways in CICs. These findings provide important insights into the mechanisms of cardiac stress and aging.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fareheh Firouzi, Oscar Echeagaray, Carolina Esquer, Natalie A. Gude, Mark A. Sussman
Summary: The heterogeneity and plasticity of cardiac fibroblast population pose challenges for the study of cardiac biology and intervention strategies. This study evaluates the role of c-Kit biology within the population of cardiac fibroblasts, providing a fundamental basis for future research.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar H. Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan M. Monsanto, Dena Yaareb, Leila Golgolab, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Clarissa Savko, Pria Bose, Sophie Rokaw, Abbie Rieder, Taha Alani, Tyler Hopkins, Carolina Esquer, Grant Shain
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar E. Echeagaray, Taeyong Kim, Alex Casillas, Megan M. Monsanto, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Fareheh Firouzi, Oscar H. Echeagaray, Carolina Y. Esquer, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar Echeagaray, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar E. Echeagaray, Taeyong Kim, Alex Casillas, Megan M. Monsanto, Mark A. Sussman
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fareheh Firouzi, Oscar H. Echeagaray, Carolina Y. Esquer, Natalie A. Gude, Mark A. Sussman
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Carolina Esquer, Clarissa Savko, Grant Shain, Oscar E. Echeagaray, Fareheh Firouzi, Pria Bose, Abbie Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie A. Gude
CIRCULATION RESEARCH
(2021)