Article
Biochemistry & Molecular Biology
Saifeng Cheng, Markus Mittnenzweig, Yoav Mayshar, Aviezer Lifshitz, Marko Dunjic, Yoach Rais, Raz Ben-Yair, Stephanie Gehrs, Elad Chomsky, Zohar Mukamel, Hernan Rubinstein, Katharina Schlereth, Netta Reines, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzer
Summary: By using temporal single-cell atlases, this study reveals that the loss of TET genes in mice leads to embryonic developmental failure. Tet-mutant cells can retain near-complete differentiation potential when developing within a wild-type embryo, but embryos solely composed of mutant cells exhibit defects in epiblast to ectoderm transition and degenerated mesoderm potential.
Review
Oncology
Chen Wang, Xue Hao, Rugang Zhang
Summary: This review summarizes the role of cellular senescence in aging and age-related diseases such as cancer. The authors discuss current strategies for targeting senescence in order to develop therapeutic interventions for cancer and promote healthy aging, and outline future research directions for senescence-based interventions.
MOLECULAR ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Darren J. Baker, Masashi Narita, Pura Munoz-Canoves
Summary: The contribution of cellular senescence in various biological processes has been overlooked but is now gaining attention. This Editorial provides an overview of the review and original work articles in The FEBS Journal's Special Issue on Senescence in Ageing and Disease. Senescent cells have both positive and negative effects on tissue injury, aging, and pathology. The identification of senescent cells has improved, especially in slow-proliferating or terminally differentiated tissues. The communication between senescent cells and other tissue residents, as well as the role of the senescence-associated secretory phenotype (SASP), are important topics in this Special Issue.
Review
Biochemistry & Molecular Biology
Helene Martini, Joao F. Passos
Summary: The article discusses how the accumulation of senescent cells in multiple tissues leads to tissue dysfunction and age-related diseases, and emphasizes the important role and mechanisms of mitochondria in senescence. It also proposes the establishment of a detailed road map of mitochondrial biology to guide future research on treatments.
Review
Cardiac & Cardiovascular Systems
Daniel J. Tyrrell, Daniel R. Goldstein
Summary: This Review discusses the mechanisms by which aging promotes atherosclerosis, focusing on the impact of external factors on myeloid cells and internal factors on mitochondrial function. Future research directions and potential therapeutic approaches are proposed to reduce the burden of atherosclerosis in older adults.
NATURE REVIEWS CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Victoria Moiseeva, Andres Cisneros, Aina Calls Cobos, Aida Bea Tarrega, Claudia Santos Onate, Eusebio Perdiguero, Antonio L. Serrano, Pura Munoz-Canoves
Summary: Cellular senescence is an irreversible cell cycle arrest state that occurs after tissue damage and in age-related diseases. Senescent cells and their multicomponent secretory phenotype (SASP) can impact tissue regeneration and function, but the effects vary depending on the tissue environment, duration of injury, persistence of senescent cells, and organism's age. Transient presence of senescent cells is believed to be beneficial for tissue regeneration, but recent data suggest it is harmful after acute damage, while persistent presence of senescent cells is typically associated with the progression of age-related chronic degenerative diseases, yet it appears to be necessary for correct tissue function in the elderly.
Review
Cell Biology
Evon Low, Ghazaleh Alimohammadiha, Lucy A. Smith, Lydia F. Costello, Stefan A. Przyborski, Thomas von Zglinicki, Satomi Miwa
Summary: Skin, as the largest organ of the body, is compromised with time due to intrinsic and extrinsic ageing processes, primarily at the cellular level through cellular senescence. While evidence suggests that cellular senescence is a relevant cause of intrinsic skin ageing, it is not yet completely conclusive.
AGEING RESEARCH REVIEWS
(2021)
Article
Pharmacology & Pharmacy
S. Hopkin, J. M. Lord, M. Chimen
Summary: As individuals age, the immune system undergoes changes that lead to inflammation and dysregulated immune cell trafficking. These age-related alterations in leukocyte trafficking are multifactorial and vary depending on the leukocyte subset, tissue, type of vascular bed, and inflammatory status.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Dermatology
Lydia Costello, Kirsty Goncalves, Paola De Los Santos Gomez, Amy Simpson, Victoria Maltman, Pamela Ritchie, Ryan Tasseff, Robert Isfort, Teresa Dicolandrea, Xingtao Wei, Arto Maatta, Iakowos Karakesisoglou, Ewa Markiewicz, Charles C. Bascom, Stefan Przyborski
Summary: Skin ageing is a complex process influenced by internal and external factors. This study analyzed skin parameters in individuals with Fitzpatrick skin types II-III to understand the effects of age and photoexposure. Differences in epidermal thickness were attributed to changes in the dermal-epidermal junction (DEJ). Basal keratinocytes showed increased cell size and a more columnar phenotype in photoexposed sites, suggesting accelerated photoageing. The study highlights the importance of early skin care education and photoprotection.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Cell Biology
Mei Jiang, Se Eun Jang, Li Zeng
Summary: In the mammalian brain, neurogenesis occurs mainly in the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) of the lateral ventricles, as well as other nonclassic neurogenic areas. Neural stem cells (NSCs) differentiate into neurons and integrate into existing neural networks during prenatal and early postnatal development. Impairments in neurogenesis can lead to brain dysfunction and neurological disorders. This review summarizes the properties and mechanisms of neurogenic niches, discusses the influence of extrinsic and intrinsic factors on neurogenesis, and explores the impact of SARS-CoV-2 infection on neurological sequelae.
Review
Biochemistry & Molecular Biology
Jaskaren Kohli, Iris Veenstra, Marco Demaria
Summary: Cellular senescence is a stable cell cycle arrest associated with macromolecular alterations and inflammation, which play important roles in controlling viral spread and activating immune responses. However, excessive and aberrant senescent cells can lead to pathology and dysfunction. Pharmacological interventions, including antiviral therapies, can induce premature senescence and have detrimental effects if not controlled properly.
Review
Biochemistry & Molecular Biology
Maria Elzbieta Mycielska, Emma Naomi James, Eric Kenneth Parkinson
Summary: Recent experiments in mouse models have shown that senescent cells play a crucial role in age-related diseases and may contribute to certain pathological conditions. The recognition of extranuclear chromatin by the cyclic GMP-AMP synthase-stimulator of interferon genes pathway leads to the induction of inflammatory cytokines, which are part of the senescence-associated secretory phenotype. This chronic inflammation increases with age and age-related diseases. In addition, senescent cells undergo metabolic changes, including the accumulation of extracellular citrate, which may also contribute to age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Miles D. Witham, Antoneta Granic, Satomi Miwa, Joao F. Passos, Gavin D. Richardson, Avan A. Sayer
Summary: Cellular senescence is a fundamental biological mechanism contributing to aging and age-related diseases. It can be induced by various mechanisms, not just replication and telomere attrition. Senescent cells secrete inflammatory mediators that drive chronic inflammation and can convert other cells to the senescent state. Research in animal models suggests that preventing or reversing senescence may be a potential strategy against aging and age-related diseases, with interventions including exercise, nutrition, and senolytics/senostatic drugs. However, it is crucial to measure outcomes reflecting improved healthy life expectancy in clinical studies to gain trust from clinicians, patients, and the public.
Review
Oncology
Alexey Ponomarev, Zarema Gilazieva, Valeriya Solovyeva, Cinzia Allegrucci, Albert Rizvanov
Summary: The study of cancer stem cells is important because they play a crucial role in cancer complexity and treatment resistance. The tumor microenvironment modulates the function and survival of cancer stem cells. This review summarizes the regulation of cancer stemness through pluripotency factors and signaling pathways, and introduces current models used for studying cancer stem cells.
Article
Biochemistry & Molecular Biology
Alma Karen Lomeli-Lepe, Jose Luis Castaneda-Cabral, Silvia Josefina Lopez-Perez
Summary: Synucleinopathies are a group of neurodegenerative disorders characterized by changes in a-synuclein, a protein associated with cell membrane phospholipids, whose exact function is still unknown. The regulation of the a-synuclein gene is believed to play a key role in the pathology of these diseases, making it one of the most studied genes. These complex disorders result from the interaction between genetic and environmental factors. This article provides an update on the epigenetic regulation of a-synuclein gene expression, as well as the influence of other factors such as posttranslational modifications, microbiota, lipid interactions, neuroinflammation, and oxidative stress, on a-synuclein aggregation.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Engineering, Biomedical
Jaeyeaon Cho, Sangsung Kim, Hyein Lee, Woongchan Rah, Hee Cheol Cho, Nam Kyun Kim, Seongho Bae, Dong Hoon Shin, Min Goo Lee, In-Hyun Park, Yoshiaki Tanaka, Eric Shin, Hong Yi, Ji Woong Han, Patrick Tae Joon Hwang, Ho-Wook Jun, Hun-Jun Park, Kyuwon Cho, Sang Wook Lee, Jae Kyung Jung, Rebecca D. Levit, Mark A. Sussman, Richard P. Harvey, Young-sup Yoon
Summary: The direct reprogramming of mouse fibroblasts into cardiomyocytes, endothelial cells, and smooth muscle cells to form cardiac tissue structures improved cardiac function when implanted into infarcted mouse hearts.
NATURE BIOMEDICAL ENGINEERING
(2021)
Review
Cardiac & Cardiovascular Systems
Oscar Echeagaray, Clarissa Savko, Andrea Gallo, Mark Sussman
Summary: This review summarizes the cardiovascular consequences of vaping and highlights the importance of research in this area. Recent findings indicate that vaping can have an impact on cardiovascular homeostasis, inflammation, and molecular changes, suggesting potential health issues associated with vaping and the need for further investigation into the pathogenesis.
CURRENT OPINION IN CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Oscar Echeagaray, Taeyong Kim, Alex Casillas, Megan Monsanto, Mark Sussman
Summary: Ex vivo expansion of cells is crucial in regenerative medicine to generate large populations for therapeutic use. The adaptation to culture conditions leads to increased transcriptome diversity and decreased population heterogeneity in cKit+ cardiac interstitial cells (cCICs). The transcriptional profiles of cells from different origins, such as neonatal versus adult tissue, show contrasting imprint of age influence on cell cycle, senescence, RNA transport, and ECM-receptor/fibrosis pathways.
Article
Biology
Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose, Abigail Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie Gude, Mark A. Sussman
Summary: Vaping of flavored liquids can lead to pulmonary injury, with profound pathological changes in upper airway, lung tissue, and cellular structure. This study also highlights the potential transcriptional reprogramming and impaired cardiac function associated with vaping.
LIFE SCIENCE ALLIANCE
(2022)
Review
Pharmacology & Pharmacy
Mark A. Sussman
Summary: Modern vaping, a rapidly growing industry, has raised concerns about its impact on human health, particularly on the lungs and cardiopulmonary system. Studies are urgently needed to understand the biological effects of vaping and develop strategies to mitigate the associated harmful effects.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cardiac & Cardiovascular Systems
Kathleen Broughton, Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan Monsanto, Dena Yaareb, Leila Golgolab, Natalie Gude, Mark A. Sussman
Summary: This study reveals that surface Lin28A serves as a marker for oxidative stress in cardiac interstitial cells (CICs) and its expression can be antagonized by antioxidant treatment. The altered localization of Lin28A is associated with senescence markers and oxidative stress pathways in CICs. These findings provide important insights into the mechanisms of cardiac stress and aging.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fareheh Firouzi, Oscar Echeagaray, Carolina Esquer, Natalie A. Gude, Mark A. Sussman
Summary: The heterogeneity and plasticity of cardiac fibroblast population pose challenges for the study of cardiac biology and intervention strategies. This study evaluates the role of c-Kit biology within the population of cardiac fibroblasts, providing a fundamental basis for future research.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar H. Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan M. Monsanto, Dena Yaareb, Leila Golgolab, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Clarissa Savko, Pria Bose, Sophie Rokaw, Abbie Rieder, Taha Alani, Tyler Hopkins, Carolina Esquer, Grant Shain
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar E. Echeagaray, Taeyong Kim, Alex Casillas, Megan M. Monsanto, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Fareheh Firouzi, Oscar H. Echeagaray, Carolina Y. Esquer, Natalie A. Gude, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathleen M. Broughton, Carolina Esquer, Oscar Echeagaray, Mark A. Sussman
Meeting Abstract
Cardiac & Cardiovascular Systems
Oscar E. Echeagaray, Taeyong Kim, Alex Casillas, Megan M. Monsanto, Mark A. Sussman
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fareheh Firouzi, Oscar H. Echeagaray, Carolina Y. Esquer, Natalie A. Gude, Mark A. Sussman
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mark A. Sussman, Carolina Esquer, Clarissa Savko, Grant Shain, Oscar E. Echeagaray, Fareheh Firouzi, Pria Bose, Abbie Rieder, Sophie Rokaw, Andrea Witon-Paulo, Natalie A. Gude
CIRCULATION RESEARCH
(2021)
