Article
Cell & Tissue Engineering
Jianyang Liu, Jialin He, Lite Ge, Han Xiao, Yan Huang, Liuwang Zeng, Zheng Jiang, Ming Lu, Zhiping Hu
Summary: The study demonstrates that hypoxic preconditioning delays OM-MSC senescence and enhances the therapeutic efficacy of OM-MSCs in ICH by upregulating the miR-326/PTBP1/PI3K-mediated autophagy pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Woo-Sup Sim, Bong-Woo Park, Kiwon Ban, Hun-Jun Park
Summary: The study explored a novel therapeutic platform called in situ preconditioning to enhance the therapeutic potential of BM-MSCs in a rat myocardial infarction model. Results showed that this approach significantly improved the survival and retention of BM-MSCs in the heart, leading to enhanced cardiac function and repair in myocardial infarction hearts. This suggests that in situ preconditioning could be an effective strategy for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Beschan Ahmad, Anna Skorska, Markus Wolfien, Haval Sadraddin, Heiko Lemcke, Praveen Vasudevan, Olaf Wolkenhauer, Gustav Steinhoff, Robert David, Ralf Gaebel
Summary: This study investigated the effects of mesenchymal stem cell (MSC) injection on post-infarction arrhythmias. The results showed that MSC therapy after double infarction significantly reduced simple and complex arrhythmias. RNA sequencing analysis also revealed a decline in arrhythmias and reduced inflammatory pathways. Additionally, the study identified highly expressed genes linked to lowering the risk of heart failure, cardiomyopathy, and sudden cardiac death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Xing Guo, Denghua Huang, Dan Li, Longfei Zou, Hui Lv, Yuanhui Wang, Meiyun Tan
Summary: This study found that hypoxia preconditioning attenuates the proliferation and migration ability of ADSCs, but has positive impact on tenogenic differentiation through HIF-1 alpha signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Veterinary Sciences
Jun Ying, Qing You, Zhiguo Wang, Zhiqian Hu
Summary: This study suggests that preconditioning mesenchymal stem cells under hypoxic conditions can enhance their therapeutic effect in treating inflammatory bowel disease.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Liqiang Sun, Wenlong Zhang
Summary: The study demonstrates that preconditioning MSCs with ghrelin can enhance cardioprotective effects, especially in elderly subjects, following IR injury. Preconditioned MSCs increase autophagy flux by downregulating Beclin-1 and P62 protein overexpression, and increasing LC3-II expression and the LC3-II/LC3-I ratio. Moreover, combining NMN with ghrelin-preconditioned MSCs synergistically enhances protective effects on infarct size and mitochondrial function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kanwal Haneef, Asmat Salim, Zehra Hashim, Amber Ilyas, Basir Syed, Aftab Ahmed, Shamshad Zarina
Summary: This study investigated the mechanism by which hypoxic preconditioning enhances the survival of mesenchymal stem cells (MSCs). Proteomic analysis revealed higher expression of certain proteins in hypoxic preconditioned (HP) MSCs, which are possibly involved in cellular survival and proliferation through various cellular pathways. This research is important for understanding the processes involved in hypoxic preconditioning of MSCs and designing cell-based therapeutic strategies for tissue regeneration.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Haeyeon Seo, Ho Joong Choi, Ok-Hee Kim, Jung Hyun Park, Ha Eun Hong, Say-June Kim
Summary: Hypoxic preconditioning appears to enhance the anti-apoptotic effects of stem cells by promoting autophagy.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyan Gao, Xiaoting Liang, Baojuan Liu, Yimei Hong, Haiwei He, Ying Shen, Jiaqi Chen, Xinran Huang, Bei Hu, Weifeng Li, Xin Li, Yuelin Zhang
Summary: In this study, the role of ALKBH5 in regulating the senescence of mesenchymal stem cells (MSCs) was investigated. ALKBH5 was found to accelerate MSC senescence through the regulation of m6A modification and stability of CDKN1C mRNA. Knockdown of ALKBH5 rejuvenated aged MSCs and improved their therapeutic efficacy for myocardial infarction.
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell & Tissue Engineering
Wei-Cheng Tseng, Pei-Ying Lee, Ming-Tsun Tsai, Fu-Pang Chang, Nien-Jung Chen, Chiang-Ting Chien, Shih-Chieh Hung, Der-Cherng Tarng
Summary: This study demonstrates that the enhancing effect of MSCs, especially HMSCs, on tissue autophagy can be applied to suppress renal tubular apoptosis and attenuate renal impairment during renal I/R injury in rats. These findings provide further mechanistic support for HMSC therapy and its investigation in clinical trials of ischemic AKI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A. Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng
Summary: The study aims to investigate the role of GRK4 in the pathogenesis and progression of myocardial infarction (MI). Results showed that GRK4 expression was increased in the heart after MI, and overexpression of GRK4 aggravated cardiac infarction and dysfunction while specific gene knockout ameliorated these effects. GRK4 inhibited autophagy and promoted cardiomyocyte apoptosis, effects mediated by HDAC4 phosphorylation and a decrease in beclin-1 expression, leading to greater impairment of cardiac function in MI patients carrying the GRK4 A486V variant.
EUROPEAN HEART JOURNAL
(2021)
Review
Cell Biology
Moein Ala
Summary: Mesenchymal stem cells (MSCs) have regenerative, anti-inflammatory, and immunomodulatory properties. They attenuate various detrimental effects after myocardial infarction (MI) and improve cardiac function. MSC-derived exosomes also show promising effects in MI treatment. However, there are still modifiable factors that need to be optimized, such as timing and route of administration, as well as MSC pretreatment approaches. Future clinical trials should consider these advances to accurately assess the efficacy of MSCs or their exosomes for MI.
AGEING RESEARCH REVIEWS
(2023)
Article
Engineering, Electrical & Electronic
Haixu Chen, Chao Bi
Summary: The study found the optimal starting frequency for a 3-phase induction motor by analyzing its characteristics, which can increase the starting torque and reduce the requirement for the motor driver.
IET ELECTRIC POWER APPLICATIONS
(2022)
Editorial Material
Cell Biology
Amy Cheuk Yin Lo, Ming Yang
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Haixu Chen, Tianpeng Wang, Xiaoning He, Xu Cai, Runmao Lin, Jianli Liang, Jian Wu, Graham King, Xiaowu Wang
Summary: The BRAD database has undergone a major upgrade to include 26 species and optimize user interface, while retaining previous features and adding new tools and modules for studying syntenic genes, gene expression, and variation data. The update provides a substantial expansion of genomic data and a comprehensive improvement of available services for the Brassicaceae research community.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Ming Yang, Michelle Grace Tsui, Jessica Kwan Wun Tsang, Rajesh Kumar Goit, Kwok-Ming Yao, Kwok-Fai So, Wai-Ching Lam, Amy Cheuk Yin Lo
Summary: This study reveals that both the GSH-GPx-4 and FSP1-CoQ(10)-NADH pathways inhibit retinal ferroptosis in RPE degeneration, suggesting potential treatment targets for RPE degenerative disorders.
CELL DEATH & DISEASE
(2022)
Editorial Material
Cell Biology
Ming Yang, Kwok-Fai So, Wai-Ching Lam, Amy Cheuk Yin Lo
NEURAL REGENERATION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Lei Zhang, Jianli Liang, Haixu Chen, Zhicheng Zhang, Jian Wu, Xiaowu Wang
Summary: We have successfully completed a near-complete genome assembly of B. rapa Chiifu v4.0 using Oxford Nanopore Technology (ONT) ultralong-read sequencing and Hi-C technologies. This new assembly contains 12 contigs, with 8 chromosomes entirely reconstructed in a single contig. We found that the centromeres were mainly invaded by ALE and CRM long terminal repeats (LTRs), and there is a high divergence of centromere length and sequence among B. rapa genomes. This study provides valuable tools for genomic and genetic studies of Brassica species and sheds new light on the evolution of centromeres.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Physical
Xiaoliang Wang, Yan Huang, Yu Ren, Shengliang Wang, Junbo Li, Youping Lin, Haixu Chen, Lei Wang, Xin Huang
Summary: Compared with individuals, proteinosomes aggregations show superior characteristics including accelerated settling velocity, survival by sacrificing outside members, resistance to negative pressure phagocytosis, and enhanced enzyme utilization rate. The construction and application of proteinosomes aggregations contribute to advancing the functionality of life-like assembled biomaterial.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Multidisciplinary
ShengLiang Wang, ZhiJun Xu, HaiXu Chen, XiaoLiang Wang, Song Lin, Lei Wang, XiaoMan Liu, Xin Huang
Summary: The biointerface engineering of living cells by creating an abiotic shell has implications for improving cellular behavior and promoting the development of living cell hybrid materials. Active nanoencapsulation of single cells endows them with motion ability that they do not possess inherently. The emerging motion characteristics of the encapsulated cells can be self-regulated, leading to self-sorting between mother cells and daughter cells in a proliferated Saccharomyces cerevisiae cell community. This study not only serves as a new technique in single-cell biology analysis and sorting, but also opens up opportunities to manipulate cell functionality by creating biohybrid materials.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2023)
Review
Virology
Michael Zhipeng Yan, Ming Yang, Ching-Lung Lai
Summary: The COVID-19 outbreak in 2019 caused a significant number of illnesses and deaths. Many COVID-19 survivors develop Post-COVID-19 Syndrome (PC19S) of varying severity. Currently, the diagnosis of PC19S relies on subjective reporting and lacks a unified diagnostic assessment tool, making patient management and rehabilitation planning difficult.
Article
Nanoscience & Nanotechnology
Shengliang Wang, Haixu Chen, Zhijun Xu, Xiaoliang Wang, Zhengyu Tao, Lei Wang, Xiaoman Liu, Xin Huang
Summary: Cell surface engineering is an effective strategy to improve cell tolerance and impart various properties. However, research on collective functionality is limited. In this study, a single cell was encapsulated with TiO2 nanoparticles and conductive polymer PPy. The engineered cells exhibited collective behaviors under different conditions, including swarming negative phototaxis migration. This technique has potential in cell therapy and biosensors.
ACS APPLIED NANO MATERIALS
(2023)
Proceedings Paper
Geosciences, Multidisciplinary
Zhi Sun, Haixu Chen, Xiaolong Li, Qian Jiang, Wanqing Fan, Xingtao Jiang, Guolong Cui
Summary: This paper proposes a novel fast method for marine moving target detection based on TSLRT-MFP-SVD. The method utilizes time slice division and echo subspace decomposition to achieve valid target detection and clutter restrain.
2022 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS 2022)
(2022)
Article
Medicine, General & Internal
Haixu Chen, Yu Lin, Lianlin Zeng, Shiwei Liu
Summary: This study explored the mechanism of Compound Hongginshen Decoction in improving pulmonary fibrosis through network pharmacology. The findings suggest that the decoction has a multi-channel and multi-targeted effect in treating pulmonary fibrosis. Radix Ophiopogonis and Dendrobium officinale play a key role in the treatment by influencing cell metabolism, anti-inflammation, immune system regulation, promoting angiogenesis, and improving anaerobic metabolism.
Article
Medicine, General & Internal
Ying Wang, Haixu Chen, Junwei Wang, Xin Chen, Lan Chen
Summary: This study investigated the pharmacological mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury using network pharmacology and molecular docking. The results showed that Buyang Huanwu Decoction primarily treats spinal cord injury by regulating immunological inflammation, apoptosis, and oxidative stress, involving multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Peiying Bai, Chen Ge, Hui Yang, Haixu Chen, Lingfei Wan, Yuchen Zhang, Biao Zhang, Quan Zeng, Zeng Fan, Xuetao Pei, Wen Yue, Xinlong Yan
Summary: In this study, Hinokitiol was identified as a potential drug for intrahepatic cholangiocarcinoma (ICC) treatment by inhibiting tumor clone and sphere formation, as well as downregulating the ERK and P38 pathways.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Plant Sciences
Jian Wu, Jianli Liang, Runmao Lin, Xu Cai, Lei Zhang, Xinlei Guo, Tianpeng Wang, Haixu Chen, Xiaowu Wang
Summary: The Brassicaceae family includes economically important crop species and is a model organism for genomic studies. The morphological plasticity of Brassicaceae crops is due to their variable genomes. Genes contributing to important traits and epigenetic alterations play roles in subgenome dominance.
HORTICULTURE RESEARCH
(2022)