Senescent cells harbour features of the cancer epigenome

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

(2016) Anne Schellenberg et al.   Aging-US

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Genomic insights into cancer-associated aberrant CpG island hypermethylation

(2013) D. Sproul et al.   Briefings in Functional Genomics

Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence

(2013) M. Sadaie et al.   GENES & DEVELOPMENT

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes

(2013) Nathan D. VanderKraats et al.   NUCLEIC ACIDS RESEARCH

Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

(2013) Nikolay A. Pchelintsev et al.   Cell Reports

DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival

(2012) Daniel D. De Carvalho et al.   CANCER CELL

Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture

(2012) Mi Ran Choi et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

(2012) Tamir Chandra et al.   MOLECULAR CELL

Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues

(2012) Gilad Landan et al.   NATURE GENETICS

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions

(2012) Kasper D Hansen et al.   GENOME BIOLOGY

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

(2011) G. C. Hon et al.   GENOME RESEARCH

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

(2011) D. T. Ting et al.   SCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation ofp16INK4a

(2010) Linda A. S. Carragher et al.   EMBO Molecular Medicine

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression

(2010) A. E. K. Ibrahim et al.   GUT

Replication timing-related and gene body-specific methylation of active human genes

(2010) Dvir Aran et al.   HUMAN MOLECULAR GENETICS

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Analysis of DNA Replication Timing Reveals Conserved Large-Scale Chromosomal Architecture

(2010) Eitan Yaffe et al.   PLoS Genetics

DNMT3B Expression Might Contribute to CpG Island Methylator Phenotype in Colorectal Cancer

(2009) K. Nosho et al.   CLINICAL CANCER RESEARCH

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

(2009) R. S. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Comparison of global DNA methylation profiles in replicative versus premature senescence

(2008) Wenjuan Zhang et al.   LIFE SCIENCES

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics